The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy

The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy

A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-cat...

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Veröffentlicht in:Chemical science (Cambridge) 2016-01, Vol.7 (4), p.2706-2710
Hauptverfasser: Fox, J C, Gilligan, R E, Pitts, A K, Bennett, H R, Gaunt, M J
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Gilligan, R E
Pitts, A K
Bennett, H R
Gaunt, M J
description A synthesis of the bioactive indolocarbazole alkaloid K-252c (staurosporinone) a sequential C-H functionalisation strategy is reported. The route exploits direct functionalisation reactions around a simple arene core and comprises of two highly-selective copper-catalysed C-H arylations, a copper-catalysed C-H amination and a palladium-catalysed C-H carbonylation, which build up the structural complexity of the natural product framework.
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title The total synthesis of K-252c (staurosporinone) via a sequential C-H functionalisation strategy
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