Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization
Objective The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF). Design This study is a retrospective cohort study. Setting This study was performed in a private academically affiliated IVF center. Patients Pati...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2017-07, Vol.34 (7), p.877-883 |
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| creator | Dodge, L. E. Missmer, S. A. Thornton, K. L. Hacker, M. R. |
| description | Objective
The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF).
Design
This study is a retrospective cohort study.
Setting
This study was performed in a private academically affiliated IVF center.
Patients
Patients included women presenting for their first IVF cycle from July 2004 through October 2012.
Intervention
Women completed self-administered questionnaires before their first IVF cycle, which included report of usual alcohol consumption. Women were categorized as non-drinkers, social drinkers, or daily drinkers, as well as by the number of drinks consumed per week. Competing risks analysis was used to calculate the cumulative incidence of live birth after 6 cycles stratified by alcohol consumption.
Main outcome measures
Main outcome measures included spontaneous abortion, clinical pregnancy, and live birth following IVF.
Results
There were 591 (27.7%) non-drinkers, 1466 (68.7%) social drinkers, and 77 (3.6%) daily drinkers (total
n
= 2134). In the first cycle, compared to non-drinkers, daily drinkers had a twofold increased risk of spontaneous abortion (adjusted risk ratio [aRR] 2.2; 95% confidence interval [CI] 1.1–4.5) among all cycle starts, and while their risk of live birth was 30% lower (aRR 0.7; 95% CI 0.4–1.3), the sample size was small, and it was not significantly lower. By the end of 6 cycles, social drinkers and daily drinkers did not differ from non-drinkers in their cumulative incidence of live birth (56.1, 50.6, and 52.1%, respectively; both
P
≥ 0.28).
Conclusion
There was a trend towards lower risk of live birth among daily drinkers. Daily drinkers had an increased risk of spontaneous abortion in the first cycle, but the number of daily drinkers was small. |
| doi_str_mv | 10.1007/s10815-017-0923-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5476540</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1911112874</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-3e8ef90590ff21285d14379a65ceee6c7a4a2c0851023f3104b662524972d2113</originalsourceid><addsrcrecordid>eNp1kc2KFDEQxxtR3HX1AbxIwMteWqvy0em-CLL4BQteFI8hk6meyZJOxqR7RE_7Gr6eT2KGWZdV8FRF1a_-VcW_aZ4ivEAA_bIg9KhaQN3CwEWr7jWnqLRotRBwv-ag-hZk1580j0q5AoCh5-Jhc8J7yQcU-rShL2mi-Ov6Z2E2uLRNgbkUyzLtZp8is3HN3DItwc5-T8xH59cUHbE0snCorHyet2xMIaRvPm4qwfZ-zomNlGcf_A970HncPBhtKPTkJp41n9---XTxvr38-O7DxevL1kkNcyuop3EANcA4cuS9WqMUerCdckTUOW2l5Q56hcDFKBDkquu44nLQfM0RxVnz6qi7W1YTrR3FOdtgdtlPNn83yXrzdyf6rdmkvVFSd0pCFTi_Ecjp60JlNpMvjkKwkdJSDPZDXQPYiYo-_we9SkuO9T2DFcJ6v5aVwiPlciol03h7DII5mGiOJppqojmYaFSdeXb3i9uJP65VgB-BUltxQ_nO6v-q_gZ44Klp</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1911112874</pqid></control><display><type>article</type><title>Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><source>PubMed Central</source><creator>Dodge, L. E. ; Missmer, S. A. ; Thornton, K. L. ; Hacker, M. R.</creator><creatorcontrib>Dodge, L. E. ; Missmer, S. A. ; Thornton, K. L. ; Hacker, M. R.</creatorcontrib><description>Objective
The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF).
Design
This study is a retrospective cohort study.
Setting
This study was performed in a private academically affiliated IVF center.
Patients
Patients included women presenting for their first IVF cycle from July 2004 through October 2012.
Intervention
Women completed self-administered questionnaires before their first IVF cycle, which included report of usual alcohol consumption. Women were categorized as non-drinkers, social drinkers, or daily drinkers, as well as by the number of drinks consumed per week. Competing risks analysis was used to calculate the cumulative incidence of live birth after 6 cycles stratified by alcohol consumption.
Main outcome measures
Main outcome measures included spontaneous abortion, clinical pregnancy, and live birth following IVF.
Results
There were 591 (27.7%) non-drinkers, 1466 (68.7%) social drinkers, and 77 (3.6%) daily drinkers (total
n
= 2134). In the first cycle, compared to non-drinkers, daily drinkers had a twofold increased risk of spontaneous abortion (adjusted risk ratio [aRR] 2.2; 95% confidence interval [CI] 1.1–4.5) among all cycle starts, and while their risk of live birth was 30% lower (aRR 0.7; 95% CI 0.4–1.3), the sample size was small, and it was not significantly lower. By the end of 6 cycles, social drinkers and daily drinkers did not differ from non-drinkers in their cumulative incidence of live birth (56.1, 50.6, and 52.1%, respectively; both
P
≥ 0.28).
Conclusion
There was a trend towards lower risk of live birth among daily drinkers. Daily drinkers had an increased risk of spontaneous abortion in the first cycle, but the number of daily drinkers was small.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-017-0923-5</identifier><identifier>PMID: 28429137</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abortion ; Abortion, Spontaneous - epidemiology ; Alcohol Drinking - adverse effects ; Alcohol use ; Alcoholic beverages ; Alcohols ; Assisted Reproduction Technologies ; Beverages ; Female ; Fertilization in Vitro ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Incidence ; Medicine ; Medicine & Public Health ; Odds Ratio ; Pregnancy ; Pregnancy Rate ; Reproductive Medicine ; Treatment Outcome</subject><ispartof>Journal of assisted reproduction and genetics, 2017-07, Vol.34 (7), p.877-883</ispartof><rights>Springer Science+Business Media New York 2017</rights><rights>Journal of Assisted Reproduction and Genetics is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-3e8ef90590ff21285d14379a65ceee6c7a4a2c0851023f3104b662524972d2113</citedby><cites>FETCH-LOGICAL-c470t-3e8ef90590ff21285d14379a65ceee6c7a4a2c0851023f3104b662524972d2113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476540/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476540/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,725,778,782,883,27907,27908,41471,42540,51302,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28429137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dodge, L. E.</creatorcontrib><creatorcontrib>Missmer, S. A.</creatorcontrib><creatorcontrib>Thornton, K. L.</creatorcontrib><creatorcontrib>Hacker, M. R.</creatorcontrib><title>Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Objective
The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF).
Design
This study is a retrospective cohort study.
Setting
This study was performed in a private academically affiliated IVF center.
Patients
Patients included women presenting for their first IVF cycle from July 2004 through October 2012.
Intervention
Women completed self-administered questionnaires before their first IVF cycle, which included report of usual alcohol consumption. Women were categorized as non-drinkers, social drinkers, or daily drinkers, as well as by the number of drinks consumed per week. Competing risks analysis was used to calculate the cumulative incidence of live birth after 6 cycles stratified by alcohol consumption.
Main outcome measures
Main outcome measures included spontaneous abortion, clinical pregnancy, and live birth following IVF.
Results
There were 591 (27.7%) non-drinkers, 1466 (68.7%) social drinkers, and 77 (3.6%) daily drinkers (total
n
= 2134). In the first cycle, compared to non-drinkers, daily drinkers had a twofold increased risk of spontaneous abortion (adjusted risk ratio [aRR] 2.2; 95% confidence interval [CI] 1.1–4.5) among all cycle starts, and while their risk of live birth was 30% lower (aRR 0.7; 95% CI 0.4–1.3), the sample size was small, and it was not significantly lower. By the end of 6 cycles, social drinkers and daily drinkers did not differ from non-drinkers in their cumulative incidence of live birth (56.1, 50.6, and 52.1%, respectively; both
P
≥ 0.28).
Conclusion
There was a trend towards lower risk of live birth among daily drinkers. Daily drinkers had an increased risk of spontaneous abortion in the first cycle, but the number of daily drinkers was small.</description><subject>Abortion</subject><subject>Abortion, Spontaneous - epidemiology</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol use</subject><subject>Alcoholic beverages</subject><subject>Alcohols</subject><subject>Assisted Reproduction Technologies</subject><subject>Beverages</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Incidence</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Odds Ratio</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Reproductive Medicine</subject><subject>Treatment Outcome</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kc2KFDEQxxtR3HX1AbxIwMteWqvy0em-CLL4BQteFI8hk6meyZJOxqR7RE_7Gr6eT2KGWZdV8FRF1a_-VcW_aZ4ivEAA_bIg9KhaQN3CwEWr7jWnqLRotRBwv-ag-hZk1580j0q5AoCh5-Jhc8J7yQcU-rShL2mi-Ov6Z2E2uLRNgbkUyzLtZp8is3HN3DItwc5-T8xH59cUHbE0snCorHyet2xMIaRvPm4qwfZ-zomNlGcf_A970HncPBhtKPTkJp41n9---XTxvr38-O7DxevL1kkNcyuop3EANcA4cuS9WqMUerCdckTUOW2l5Q56hcDFKBDkquu44nLQfM0RxVnz6qi7W1YTrR3FOdtgdtlPNn83yXrzdyf6rdmkvVFSd0pCFTi_Ecjp60JlNpMvjkKwkdJSDPZDXQPYiYo-_we9SkuO9T2DFcJ6v5aVwiPlciol03h7DII5mGiOJppqojmYaFSdeXb3i9uJP65VgB-BUltxQ_nO6v-q_gZ44Klp</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Dodge, L. E.</creator><creator>Missmer, S. A.</creator><creator>Thornton, K. L.</creator><creator>Hacker, M. R.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170701</creationdate><title>Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization</title><author>Dodge, L. E. ; Missmer, S. A. ; Thornton, K. L. ; Hacker, M. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3e8ef90590ff21285d14379a65ceee6c7a4a2c0851023f3104b662524972d2113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abortion</topic><topic>Abortion, Spontaneous - epidemiology</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Alcohols</topic><topic>Assisted Reproduction Technologies</topic><topic>Beverages</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Incidence</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Odds Ratio</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Reproductive Medicine</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dodge, L. E.</creatorcontrib><creatorcontrib>Missmer, S. A.</creatorcontrib><creatorcontrib>Thornton, K. L.</creatorcontrib><creatorcontrib>Hacker, M. R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dodge, L. E.</au><au>Missmer, S. A.</au><au>Thornton, K. L.</au><au>Hacker, M. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2017-07-01</date><risdate>2017</risdate><volume>34</volume><issue>7</issue><spage>877</spage><epage>883</epage><pages>877-883</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Objective
The objective of this study was to determine the effect of alcohol consumption on outcomes among women undergoing in vitro fertilization (IVF).
Design
This study is a retrospective cohort study.
Setting
This study was performed in a private academically affiliated IVF center.
Patients
Patients included women presenting for their first IVF cycle from July 2004 through October 2012.
Intervention
Women completed self-administered questionnaires before their first IVF cycle, which included report of usual alcohol consumption. Women were categorized as non-drinkers, social drinkers, or daily drinkers, as well as by the number of drinks consumed per week. Competing risks analysis was used to calculate the cumulative incidence of live birth after 6 cycles stratified by alcohol consumption.
Main outcome measures
Main outcome measures included spontaneous abortion, clinical pregnancy, and live birth following IVF.
Results
There were 591 (27.7%) non-drinkers, 1466 (68.7%) social drinkers, and 77 (3.6%) daily drinkers (total
n
= 2134). In the first cycle, compared to non-drinkers, daily drinkers had a twofold increased risk of spontaneous abortion (adjusted risk ratio [aRR] 2.2; 95% confidence interval [CI] 1.1–4.5) among all cycle starts, and while their risk of live birth was 30% lower (aRR 0.7; 95% CI 0.4–1.3), the sample size was small, and it was not significantly lower. By the end of 6 cycles, social drinkers and daily drinkers did not differ from non-drinkers in their cumulative incidence of live birth (56.1, 50.6, and 52.1%, respectively; both
P
≥ 0.28).
Conclusion
There was a trend towards lower risk of live birth among daily drinkers. Daily drinkers had an increased risk of spontaneous abortion in the first cycle, but the number of daily drinkers was small.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>28429137</pmid><doi>10.1007/s10815-017-0923-5</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1058-0468 |
| ispartof | Journal of assisted reproduction and genetics, 2017-07, Vol.34 (7), p.877-883 |
| issn | 1058-0468 1573-7330 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5476540 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals; PubMed Central |
| subjects | Abortion Abortion, Spontaneous - epidemiology Alcohol Drinking - adverse effects Alcohol use Alcoholic beverages Alcohols Assisted Reproduction Technologies Beverages Female Fertilization in Vitro Gynecology Human Genetics Humans In vitro fertilization Incidence Medicine Medicine & Public Health Odds Ratio Pregnancy Pregnancy Rate Reproductive Medicine Treatment Outcome |
| title | Women’s alcohol consumption and cumulative incidence of live birth following in vitro fertilization |
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