The behavioral and physiological effects of high‐fat diet and alcohol consumption: Sex differences in C57BL6/J mice

Background and Objective Animal studies can be a great tool to investigate sex differences in a variety of different ways, including behavioral and physiological responses to drug treatments and different “lifestyle variables” such as diets. Consumption of both high‐fat diets and alcohol is known to...

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Veröffentlicht in:Brain and behavior 2017-06, Vol.7 (6), p.e00708-n/a
Hauptverfasser: Gelineau, Rachel R., Arruda, Nicole L., Hicks, Jasmin A., Monteiro De Pina, Isabella, Hatzidis, Aikaterini, Seggio, Joseph A.
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container_issue 6
container_start_page e00708
container_title Brain and behavior
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creator Gelineau, Rachel R.
Arruda, Nicole L.
Hicks, Jasmin A.
Monteiro De Pina, Isabella
Hatzidis, Aikaterini
Seggio, Joseph A.
description Background and Objective Animal studies can be a great tool to investigate sex differences in a variety of different ways, including behavioral and physiological responses to drug treatments and different “lifestyle variables” such as diets. Consumption of both high‐fat diets and alcohol is known to affect anxiety behaviors and overall health. This project investigated how high‐fat diet and alcohol access and its combination affected the behavior and physiology of male and female C57BL/6J mice. Method Mice were separated into three food groups: high‐fat diet, 10% fat diet, and regular chow, and each group was paired with either water or 10% alcohol. Behavioral assays included diet and alcohol preference, light‐dark box, open field, and feeding and drinking measurements. Physiological measures included glucose tolerance tests and measurement of brain‐derived neurotrophic factor, insulin, and leptin levels. Results Females and males differed in the open field, as male mice decreased activity, while females increased activity when consuming high‐fat diet. While females consumed more ethanol than males, alcohol consumption was able to improve glucose tolerance and increase anxiety in both sexes. Lastly, females were more resistant to the physiological changes caused by high‐fat diet than males, as females consuming high‐fat diet exhibited decreased insulin secretion, less change to brain‐derived neurotrophic factor levels, and better glucose tolerance than males consuming high‐fat diet. Conclusion These results suggest that the response to high‐fat diet and alcohol consumption is sex dependent and that males are more affected both behaviorally and physiologically by high‐fat diet compared to females. Sex differences in C57BL6/J mice were observed for both behavior and overall health when consuming high‐fat diet and alcohol. Female mice were more resistant to changes in behavior and health when consuming high‐fat diet as they exhibited reduced body weight gain, reduced insulin levels, and had increased locomotion in the open field compared to males. While female mice consumed more ethanol, ethanol was able to equally improve glucose tolerance and worsen anxiety in both sexes.
doi_str_mv 10.1002/brb3.708
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Consumption of both high‐fat diets and alcohol is known to affect anxiety behaviors and overall health. This project investigated how high‐fat diet and alcohol access and its combination affected the behavior and physiology of male and female C57BL/6J mice. Method Mice were separated into three food groups: high‐fat diet, 10% fat diet, and regular chow, and each group was paired with either water or 10% alcohol. Behavioral assays included diet and alcohol preference, light‐dark box, open field, and feeding and drinking measurements. Physiological measures included glucose tolerance tests and measurement of brain‐derived neurotrophic factor, insulin, and leptin levels. Results Females and males differed in the open field, as male mice decreased activity, while females increased activity when consuming high‐fat diet. While females consumed more ethanol than males, alcohol consumption was able to improve glucose tolerance and increase anxiety in both sexes. Lastly, females were more resistant to the physiological changes caused by high‐fat diet than males, as females consuming high‐fat diet exhibited decreased insulin secretion, less change to brain‐derived neurotrophic factor levels, and better glucose tolerance than males consuming high‐fat diet. Conclusion These results suggest that the response to high‐fat diet and alcohol consumption is sex dependent and that males are more affected both behaviorally and physiologically by high‐fat diet compared to females. Sex differences in C57BL6/J mice were observed for both behavior and overall health when consuming high‐fat diet and alcohol. Female mice were more resistant to changes in behavior and health when consuming high‐fat diet as they exhibited reduced body weight gain, reduced insulin levels, and had increased locomotion in the open field compared to males. While female mice consumed more ethanol, ethanol was able to equally improve glucose tolerance and worsen anxiety in both sexes.</description><identifier>ISSN: 2162-3279</identifier><identifier>EISSN: 2162-3279</identifier><identifier>DOI: 10.1002/brb3.708</identifier><identifier>PMID: 28638713</identifier><language>eng</language><publisher>United States: John Wiley and Sons Inc</publisher><subject>alcohol ; Alcohol Drinking - adverse effects ; Alcohol Drinking - physiopathology ; Animals ; anxiety ; behavior ; Behavior, Animal - drug effects ; Brain-Derived Neurotrophic Factor - blood ; C57BL/6 ; Central Nervous System Depressants - pharmacology ; Diet, High-Fat - adverse effects ; Diet, High-Fat - psychology ; Ethanol - pharmacology ; Female ; Glucose Tolerance Test ; high‐fat diet ; Leptin - blood ; locomotor ; Male ; Mice ; Mice, Inbred C57BL ; mouse ; Original Research ; preference ; sex difference ; Sex Factors ; Statistics as Topic ; type 2 diabetes</subject><ispartof>Brain and behavior, 2017-06, Vol.7 (6), p.e00708-n/a</ispartof><rights>2017 The Authors. published by Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-7315-1462</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474711/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474711/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,1419,11569,27931,27932,45581,45582,46059,46483,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28638713$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gelineau, Rachel R.</creatorcontrib><creatorcontrib>Arruda, Nicole L.</creatorcontrib><creatorcontrib>Hicks, Jasmin A.</creatorcontrib><creatorcontrib>Monteiro De Pina, Isabella</creatorcontrib><creatorcontrib>Hatzidis, Aikaterini</creatorcontrib><creatorcontrib>Seggio, Joseph A.</creatorcontrib><title>The behavioral and physiological effects of high‐fat diet and alcohol consumption: Sex differences in C57BL6/J mice</title><title>Brain and behavior</title><addtitle>Brain Behav</addtitle><description>Background and Objective Animal studies can be a great tool to investigate sex differences in a variety of different ways, including behavioral and physiological responses to drug treatments and different “lifestyle variables” such as diets. Consumption of both high‐fat diets and alcohol is known to affect anxiety behaviors and overall health. This project investigated how high‐fat diet and alcohol access and its combination affected the behavior and physiology of male and female C57BL/6J mice. Method Mice were separated into three food groups: high‐fat diet, 10% fat diet, and regular chow, and each group was paired with either water or 10% alcohol. Behavioral assays included diet and alcohol preference, light‐dark box, open field, and feeding and drinking measurements. Physiological measures included glucose tolerance tests and measurement of brain‐derived neurotrophic factor, insulin, and leptin levels. Results Females and males differed in the open field, as male mice decreased activity, while females increased activity when consuming high‐fat diet. While females consumed more ethanol than males, alcohol consumption was able to improve glucose tolerance and increase anxiety in both sexes. Lastly, females were more resistant to the physiological changes caused by high‐fat diet than males, as females consuming high‐fat diet exhibited decreased insulin secretion, less change to brain‐derived neurotrophic factor levels, and better glucose tolerance than males consuming high‐fat diet. Conclusion These results suggest that the response to high‐fat diet and alcohol consumption is sex dependent and that males are more affected both behaviorally and physiologically by high‐fat diet compared to females. Sex differences in C57BL6/J mice were observed for both behavior and overall health when consuming high‐fat diet and alcohol. Female mice were more resistant to changes in behavior and health when consuming high‐fat diet as they exhibited reduced body weight gain, reduced insulin levels, and had increased locomotion in the open field compared to males. While female mice consumed more ethanol, ethanol was able to equally improve glucose tolerance and worsen anxiety in both sexes.</description><subject>alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - physiopathology</subject><subject>Animals</subject><subject>anxiety</subject><subject>behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Brain-Derived Neurotrophic Factor - blood</subject><subject>C57BL/6</subject><subject>Central Nervous System Depressants - pharmacology</subject><subject>Diet, High-Fat - adverse effects</subject><subject>Diet, High-Fat - psychology</subject><subject>Ethanol - pharmacology</subject><subject>Female</subject><subject>Glucose Tolerance Test</subject><subject>high‐fat diet</subject><subject>Leptin - blood</subject><subject>locomotor</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>mouse</subject><subject>Original Research</subject><subject>preference</subject><subject>sex difference</subject><subject>Sex Factors</subject><subject>Statistics as Topic</subject><subject>type 2 diabetes</subject><issn>2162-3279</issn><issn>2162-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNpVkc9O3DAQxq2qqCBA6hNUPnIJ2J7EzvaAxK5a2molJNi75TjjjaskDnEC3Vsfoc_YJ8GUP6JzmZHn5--T_RHykbNTzpg4q8YKThUr35EDwaXIQKjF-zfzPjmO8SdLVfBc5OwD2RelhFJxOCDzpkFaYWPufBhNS01f06HZRR_asPU2naBzaKdIg6ON3zZ_f_9xZqK1x-kfbFobmtBSG_o4d8PkQ_-Z3uCvRKSLI_YWI_U9XRVquZZnP2jnLR6RPWfaiMfP_ZBsvn7ZrL5l66vL76uLdTYAlGWmipqLsqqNYYtCVNJJUTpnDEqAmoExBZS2yiWD2nFlCguSKedYIhZOIRyS8yfZYa46rC32U3qjHkbfmXGng_H6_03vG70Nd7rIVa44TwInzwJjuJ0xTrrz0WLbmh7DHDVfcCE5gIKEfnrr9Wry8tUJyJ6Ae9_i7nXPmX5MUT-mqFOKenm9hNThAdnhkSo</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Gelineau, Rachel R.</creator><creator>Arruda, Nicole L.</creator><creator>Hicks, Jasmin A.</creator><creator>Monteiro De Pina, Isabella</creator><creator>Hatzidis, Aikaterini</creator><creator>Seggio, Joseph A.</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7315-1462</orcidid></search><sort><creationdate>201706</creationdate><title>The behavioral and physiological effects of high‐fat diet and alcohol consumption: Sex differences in C57BL6/J mice</title><author>Gelineau, Rachel R. ; Arruda, Nicole L. ; Hicks, Jasmin A. ; Monteiro De Pina, Isabella ; Hatzidis, Aikaterini ; Seggio, Joseph A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3388-75d128bdaa0952b6f628ffaae633d03aa538cb4603df17a5c3607ff0aae9f7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>alcohol</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - physiopathology</topic><topic>Animals</topic><topic>anxiety</topic><topic>behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>Brain-Derived Neurotrophic Factor - blood</topic><topic>C57BL/6</topic><topic>Central Nervous System Depressants - pharmacology</topic><topic>Diet, High-Fat - adverse effects</topic><topic>Diet, High-Fat - psychology</topic><topic>Ethanol - pharmacology</topic><topic>Female</topic><topic>Glucose Tolerance Test</topic><topic>high‐fat diet</topic><topic>Leptin - blood</topic><topic>locomotor</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>mouse</topic><topic>Original Research</topic><topic>preference</topic><topic>sex difference</topic><topic>Sex Factors</topic><topic>Statistics as Topic</topic><topic>type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gelineau, Rachel R.</creatorcontrib><creatorcontrib>Arruda, Nicole L.</creatorcontrib><creatorcontrib>Hicks, Jasmin A.</creatorcontrib><creatorcontrib>Monteiro De Pina, Isabella</creatorcontrib><creatorcontrib>Hatzidis, Aikaterini</creatorcontrib><creatorcontrib>Seggio, Joseph A.</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gelineau, Rachel R.</au><au>Arruda, Nicole L.</au><au>Hicks, Jasmin A.</au><au>Monteiro De Pina, Isabella</au><au>Hatzidis, Aikaterini</au><au>Seggio, Joseph A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The behavioral and physiological effects of high‐fat diet and alcohol consumption: Sex differences in C57BL6/J mice</atitle><jtitle>Brain and behavior</jtitle><addtitle>Brain Behav</addtitle><date>2017-06</date><risdate>2017</risdate><volume>7</volume><issue>6</issue><spage>e00708</spage><epage>n/a</epage><pages>e00708-n/a</pages><issn>2162-3279</issn><eissn>2162-3279</eissn><abstract>Background and Objective Animal studies can be a great tool to investigate sex differences in a variety of different ways, including behavioral and physiological responses to drug treatments and different “lifestyle variables” such as diets. 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Lastly, females were more resistant to the physiological changes caused by high‐fat diet than males, as females consuming high‐fat diet exhibited decreased insulin secretion, less change to brain‐derived neurotrophic factor levels, and better glucose tolerance than males consuming high‐fat diet. Conclusion These results suggest that the response to high‐fat diet and alcohol consumption is sex dependent and that males are more affected both behaviorally and physiologically by high‐fat diet compared to females. Sex differences in C57BL6/J mice were observed for both behavior and overall health when consuming high‐fat diet and alcohol. Female mice were more resistant to changes in behavior and health when consuming high‐fat diet as they exhibited reduced body weight gain, reduced insulin levels, and had increased locomotion in the open field compared to males. 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source MEDLINE; DOAJ Directory of Open Access Journals; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection); PubMed Central
subjects alcohol
Alcohol Drinking - adverse effects
Alcohol Drinking - physiopathology
Animals
anxiety
behavior
Behavior, Animal - drug effects
Brain-Derived Neurotrophic Factor - blood
C57BL/6
Central Nervous System Depressants - pharmacology
Diet, High-Fat - adverse effects
Diet, High-Fat - psychology
Ethanol - pharmacology
Female
Glucose Tolerance Test
high‐fat diet
Leptin - blood
locomotor
Male
Mice
Mice, Inbred C57BL
mouse
Original Research
preference
sex difference
Sex Factors
Statistics as Topic
type 2 diabetes
title The behavioral and physiological effects of high‐fat diet and alcohol consumption: Sex differences in C57BL6/J mice
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