Next-gen sequencing identifies non-coding variation disrupting miRNA-binding sites in neurological disorders

Understanding the genetic factors underlying neurodevelopmental and neuropsychiatric disorders is a major challenge given their prevalence and potential severity for quality of life. While large-scale genomic screens have made major advances in this area, for many disorders the genetic underpinnings...

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Veröffentlicht in:	Molecular psychiatry 2018-05, Vol.23 (5), p.1375-1384
Hauptverfasser:	Devanna, P, Chen, X S, Ho, J, Gajewski, D, Smith, S D, Gialluisi, A, Francks, C, Fisher, S E, Newbury, D F, Vernes, S C
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/106 13/109 13/44 3' Untranslated regions 3' Untranslated Regions - genetics 38/70 45/43 45/47 45/77 631/208 692/699 692/699/476 Adult Autism Autistic Disorder - genetics Behavioral Sciences Binding Sites - genetics Biological Psychology Bipolar disorder Bipolar Disorder - genetics Brain Child Children Cohort Studies DNA, Intergenic - genetics Female Gene expression Gene Expression Regulation - genetics Gene regulation Genetic aspects Genetic factors Genetic Predisposition to Disease Genetic Variation - genetics Genomes Genomics Health aspects High-Throughput Nucleotide Sequencing - methods Humans Language Development Disorders - genetics Language disorders Male Medicine Medicine & Public Health Mental disorders Mental Disorders - genetics MicroRNA MicroRNAs - genetics miRNA Nervous System Diseases - genetics Neurodevelopmental disorders Neurodevelopmental Disorders - genetics Neurogenetics Neurological diseases Neurological disorders Neurosciences Non-coding RNA Original original-article Pharmacotherapy Physiological aspects Psychiatric research Psychiatry Quality of life Regulatory sequences Risk factors Schizophrenia Schizophrenia - genetics Screens Sequence Analysis - methods
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