Type II Endometrial Cancer Overexpresses NILCO: A Preliminary Evaluation

Objective. The expression of NILCO molecules (Notch, IL-1, and leptin crosstalk outcome) and the association with obesity were investigated in types I and II endometrial cancer (EmCa). Additionally, the involvement of NILCO in leptin-induced invasiveness of EmCa cells was investigated. Methods. The...

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Veröffentlicht in:	Disease markers 2017-01, Vol.2017 (2017), p.1-14
Hauptverfasser:	Gonzalez-Perez, Ruben Rene, Pattillo, Roland, Candelaria, Pierre V., Lee, Regina, Lanier, Viola, Vann, Kiara T., Oprea-Ilies, Gabriela, Daley-Brown, Danielle, Quarshie, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Papillary - complications Adenocarcinoma, Papillary - diagnosis Adenocarcinoma, Papillary - ethnology Adenocarcinoma, Papillary - genetics Aged Antibodies - pharmacology Asian People Biological markers Biomarkers Black or African American Black People Cancer Carcinoma, Endometrioid - complications Carcinoma, Endometrioid - diagnosis Carcinoma, Endometrioid - ethnology Carcinoma, Endometrioid - genetics Cell Line, Tumor Cell Proliferation - drug effects Crosstalk Cystadenocarcinoma, Serous - complications Cystadenocarcinoma, Serous - diagnosis Cystadenocarcinoma, Serous - ethnology Cystadenocarcinoma, Serous - genetics Cytoplasm Development and progression Diamines - pharmacology Disease Progression Endometrial cancer Endometrial Neoplasms - complications Endometrial Neoplasms - diagnosis Endometrial Neoplasms - ethnology Endometrial Neoplasms - genetics Endometrium Endometrium - metabolism Endometrium - pathology Female Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Humans Inhibitors Interleukin 1 Interleukin-1 - antagonists & inhibitors Interleukin-1 - genetics Interleukin-1 - metabolism Invasiveness Leptin Leptin - genetics Leptin - metabolism Middle Aged Neoplasm Staging Obesity Obesity - complications Obesity - diagnosis Obesity - ethnology Obesity - genetics Patients Phenotypes Protein Isoforms - antagonists & inhibitors Protein Isoforms - genetics Protein Isoforms - metabolism Proteins Receptor, Notch1 - antagonists & inhibitors Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Signal Transduction Signaling Thiazoles - pharmacology
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