Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV + Patients

Human papillomavirus (HPV) 16 plays an etiologic role in a growing subset of head and neck squamous cell carcinomas (HNSCC), where viral expression of the E6 and E7 oncoproteins is necessary for tumor growth and maintenance. Although patients with HPV tumors have a more favorable prognosis, there ar...

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Veröffentlicht in:	Clinical cancer research 2017-06, Vol.23 (12), p.3072-3083
Hauptverfasser:	Brand, Toni M, Hartmann, Stefan, Bhola, Neil E, Peyser, Noah D, Li, Hua, Zeng, Yan, Isaacson Wechsler, Erin, Ranall, Max V, Bandyopadhyay, Sourav, Duvvuri, Umamaheswar, LaVallee, Theresa M, Jordan, Richard C K, Johnson, Daniel E, Grandis, Jennifer R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Animals Biotechnology Cancer Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - virology Cell Line, Tumor Elafin - genetics Etiology Experimental design Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Viral - genetics Head Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - virology Human papillomavirus Human papillomavirus 16 - pathogenicity Humans Investigations Kinases Medical prognosis Mice Molecular Targeted Therapy Monoclonal antibodies Oncogene Proteins, Viral - genetics Papillomavirus E7 Proteins - genetics Papillomavirus Infections - genetics Papillomavirus Infections - virology Patients Pharynx Protein-tyrosine kinase receptors Receptor, ErbB-3 - antagonists & inhibitors Receptor, ErbB-3 - genetics Repressor Proteins - genetics RNA, Small Interfering - administration & dosage RNA, Small Interfering - genetics Signaling siRNA Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Therapy Tumors Tyrosine Xenograft Model Antitumor Assays Xenografts
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