Sphingolipids and Lipoproteins in Health and Metabolic Disorders
Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as progn...
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Veröffentlicht in: | Trends in endocrinology and metabolism 2017-07, Vol.28 (7), p.506-518 |
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creator | Iqbal, Jahangir Walsh, Meghan T Hammad, Samar M Hussain, M. Mahmood |
description | Sphingolipids are structurally and functionally diverse molecules with significant physiologic functions and are found associated with cellular membranes and plasma lipoproteins. The cellular and plasma concentrations of sphingolipids are altered in several metabolic disorders and may serve as prognostic and diagnostic markers. Here we discuss various sphingolipid transport mechanisms and highlight how changes in cellular and plasma sphingolipid levels contribute to cardiovascular disease, obesity, diabetes, insulin resistance, and nonalcoholic fatty liver disease (NAFLD). Understanding of the mechanisms involved in intracellular transport, secretion, and extracellular transport may provide novel information that might be amenable to therapeutic targeting for the treatment of various metabolic disorders. |
doi_str_mv | 10.1016/j.tem.2017.03.005 |
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Understanding of the mechanisms involved in intracellular transport, secretion, and extracellular transport may provide novel information that might be amenable to therapeutic targeting for the treatment of various metabolic disorders.</description><subject>Animals</subject><subject>ceramide</subject><subject>Endocrinology & Metabolism</subject><subject>Health</subject><subject>Humans</subject><subject>Insulin Resistance - physiology</subject><subject>lipoproteins</subject><subject>Lipoproteins - blood</subject><subject>Lipoproteins - metabolism</subject><subject>Lipoproteins - physiology</subject><subject>Metabolic Diseases - blood</subject><subject>Metabolic Diseases - etiology</subject><subject>Metabolic Diseases - metabolism</subject><subject>metabolic disorders</subject><subject>MTP</subject><subject>sphingolipids</subject><subject>Sphingolipids - blood</subject><subject>Sphingolipids - metabolism</subject><subject>Sphingolipids - physiology</subject><subject>sphingomyelin</subject><issn>1043-2760</issn><issn>1879-3061</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxSMEoqXwAbigHLkkzNiOkxVSBSp_irSIQ-E8cpxJ10vWDna2Ur89XrZUwIHTjDTvvbF_UxTPEWoE1K-29cK7WgC2NcgaoHlQnGLXrioJGh_mHpSsRKvhpHiS0hYAVYfN4-JEdEqLDvG0eHM1b5y_DpOb3ZBK44dy7eYwx7Cw86l0vrxkMy2bX6PPvJg-a235zqUQB47pafFoNFPiZ3f1rPj24f3Xi8tq_eXjp4u368o2rVgqi4MRAwJoiXI0CiV3pseGtRyFltr0Y2ca7tVKaq3N2KMS4wrtIFTboOjlWXF-zJ33_Y4Hy36JZqI5up2JtxSMo78n3m3oOtxQo9q8DXPAy7uAGH7sOS20c8nyNBnPYZ8Iu5VqBEipshSPUhtDSpHH-zUIdCBPW8rk6UCeQFImnz0v_nzfveM36ix4fRRwpnTjOFKyjr3lwUW2Cw3B_Tf-_B-3nZx31kzf-ZbTNuyjz_gJKQkCujqc_nB5bCVA_r_8CcvhqUU</recordid><startdate>20170701</startdate><enddate>20170701</enddate><creator>Iqbal, Jahangir</creator><creator>Walsh, Meghan T</creator><creator>Hammad, Samar M</creator><creator>Hussain, M. 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source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Animals ceramide Endocrinology & Metabolism Health Humans Insulin Resistance - physiology lipoproteins Lipoproteins - blood Lipoproteins - metabolism Lipoproteins - physiology Metabolic Diseases - blood Metabolic Diseases - etiology Metabolic Diseases - metabolism metabolic disorders MTP sphingolipids Sphingolipids - blood Sphingolipids - metabolism Sphingolipids - physiology sphingomyelin |
title | Sphingolipids and Lipoproteins in Health and Metabolic Disorders |
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