A novel NFIA-NFκB feed-forward loop contributes to glioblastoma cell survival

The nuclear factor I-A (NFIA) transcription factor promotes glioma growth and inhibits apoptosis in glioblastoma (GBM) cells. Here we report that the NFIA pro-survival effect in GBM is mediated in part via a novel NFIA-nuclear factor-kappaB (NFκB) p65 feed-forward loop. We examined effects of gain-...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2017-04, Vol.19 (4), p.524-534
Hauptverfasser:	Lee, JunSung, Hoxha, Edlira, Song, Hae-Ri
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Basic and Translational Investigations Brain Neoplasms - metabolism Cell Survival Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Glioblastoma - metabolism Humans NFI Transcription Factors - metabolism Transcription Factor RelA - metabolism Tumor Cells, Cultured
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