TRIM24 protein promotes and TRIM32 protein inhibits cardiomyocyte hypertrophy via regulation of dysbindin protein levels

We have previously shown that dysbindin is a potent inducer of cardiomyocyte hypertrophy via activation of Rho-dependent serum-response factor (SRF) signaling. We have now performed a yeast two-hybrid screen using dysbindin as bait against a cardiac cDNA library to identify the cardiac dysbindin int...

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Veröffentlicht in:	The Journal of biological chemistry 2017-06, Vol.292 (24), p.10180-10196
Hauptverfasser:	Borlepawar, Ankush, Rangrez, Ashraf Yusuf, Bernt, Alexander, Christen, Lynn, Sossalla, Samuel, Frank, Derk, Frey, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Apoptosis cardiac hypertrophy cardiac signaling cardiomyocyte cardiomyopathy Cardiomyopathy, Dilated - metabolism Cardiomyopathy, Dilated - pathology Cardiomyopathy, Hypertrophic - metabolism Cardiomyopathy, Hypertrophic - pathology Carrier Proteins - antagonists & inhibitors Carrier Proteins - genetics Carrier Proteins - metabolism Cells, Cultured Dysbindin Dystrophin-Associated Proteins - chemistry Dystrophin-Associated Proteins - genetics Dystrophin-Associated Proteins - metabolism HEK293 Cells Humans Molecular Bases of Disease Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Protein Stability Proteolysis Rats Rats, Wistar Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Recombinant Proteins - chemistry Recombinant Proteins - metabolism RNA Interference Serum Response Factor - agonists Serum Response Factor - antagonists & inhibitors Serum Response Factor - genetics Serum Response Factor - metabolism Signal Transduction SRF-signaling Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription Factors - metabolism TRIM24 TRIM32 Tripartite Motif Proteins - antagonists & inhibitors Tripartite Motif Proteins - genetics Tripartite Motif Proteins - metabolism Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism X-linked inhibitor of apoptosis protein (XIAP)
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