The soluble protease ADAMDEC1 released from activated platelets hydrolyzes platelet membrane pro-epidermal growth factor (EGF) to active high-molecular-weight EGF

Platelets are the sole source of EGF in circulation, yet how EGF is stored or released from stimulated cells is undefined. In fact, we found platelets did not store EGF, synthesized as a single 6-kDa domain in pro-EGF, but rather expressed intact pro-EGF precursor on granular and plasma membranes. A...

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Veröffentlicht in:The Journal of biological chemistry 2017-06, Vol.292 (24), p.10112-10122
Hauptverfasser: Chen, Rui, Jin, Ge, McIntyre, Thomas M.
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Sprache:eng
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