Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431)
Background: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter - reducing morpholo...
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| Veröffentlicht in: | Surgical neurology international 2017-01, Vol.8 (1), p.104-104 |
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| creator | Hongo, Hiroki Miyawaki, Satoru Imai, Hideaki Shinya, Yuki Ono, Hideaki Mori, Harushi Nakatomi, Hirofumi Kunimatsu, Akira Saito, Nobuhito |
| description | Background: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter - reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atherosclerotic middle cerebral artery (MCA).
Methods: Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging.
Results: Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10-6). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10-3). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10-5).
Conclusions: This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS. |
| doi_str_mv | 10.4103/sni.sni_59_17 |
| format | Article |
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Methods: Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging.
Results: Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10-6). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10-3). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10-5).
Conclusions: This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS.</description><identifier>ISSN: 2152-7806</identifier><identifier>ISSN: 2229-5097</identifier><identifier>EISSN: 2152-7806</identifier><identifier>DOI: 10.4103/sni.sni_59_17</identifier><identifier>PMID: 28695051</identifier><language>eng</language><publisher>United States: Wolters Kluwer India Pvt. Ltd</publisher><subject>Angina pectoris ; Atherosclerosis ; Deoxyribonucleic acid ; DNA ; Medical imaging ; Medicine ; Morphology ; Neurosurgery ; Neurovascular: Original ; NMR ; Nuclear magnetic resonance ; Stroke ; Veins & arteries</subject><ispartof>Surgical neurology international, 2017-01, Vol.8 (1), p.104-104</ispartof><rights>Copyright Medknow Publications & Media Pvt. Ltd. 2017</rights><rights>Copyright: © 2017 Surgical Neurology International 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330r-6f6713e16435dafbfd38ece4e4eeb84bfbf45661054bd39f6bec4075f26cb7873</citedby><cites>FETCH-LOGICAL-c330r-6f6713e16435dafbfd38ece4e4eeb84bfbf45661054bd39f6bec4075f26cb7873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473080/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473080/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28695051$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hongo, Hiroki</creatorcontrib><creatorcontrib>Miyawaki, Satoru</creatorcontrib><creatorcontrib>Imai, Hideaki</creatorcontrib><creatorcontrib>Shinya, Yuki</creatorcontrib><creatorcontrib>Ono, Hideaki</creatorcontrib><creatorcontrib>Mori, Harushi</creatorcontrib><creatorcontrib>Nakatomi, Hirofumi</creatorcontrib><creatorcontrib>Kunimatsu, Akira</creatorcontrib><creatorcontrib>Saito, Nobuhito</creatorcontrib><title>Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431)</title><title>Surgical neurology international</title><addtitle>Surg Neurol Int</addtitle><description>Background: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter - reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atherosclerotic middle cerebral artery (MCA).
Methods: Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging.
Results: Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10-6). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10-3). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10-5).
Conclusions: This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS.</description><subject>Angina pectoris</subject><subject>Atherosclerosis</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Morphology</subject><subject>Neurosurgery</subject><subject>Neurovascular: Original</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Stroke</subject><subject>Veins & arteries</subject><issn>2152-7806</issn><issn>2229-5097</issn><issn>2152-7806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkU1r3DAQhkVpaUKaY69F0Et78FZjfdmXQAhNWkga6NdVyPK4q8S2UsnuJv8-2uxmSSESkoaZh1fDvIS8BbYQwPinNPpFPkbWBvQLsl-CLAtdMfXySbxHDlO6YnlxDsDq12SvrFQtmYR9cvtjsH2PkYZ5ynfr7YDrIHTUTkuMIblcDZN3dPBt2yN1GLGJtqc2ZvCO2pSC83bClq78tKTfv52WwKlbgJBanR0d0982ejtO9ENMAKXmUnD4-Ia86myf8HD7HpBfp59_nnwpzi_Pvp4cnxeOcxYL1SkNHEEJLlvbNV3LK3Qo8samEk3OCKkUMCmaltedatAJpmVXKtfoSvMDcrTRvZmbAVuH45SbNzfRDzbemWC9-b8y-qX5E_4ZKTRnFcsC77cCMfydMU3mKsxxzD0bqLmCSkClMlVsKJdHliJ2ux-AmbVXZu3TzqvMv3va1o5-dCYDFxtgFfo853TdzyuMJrPXY1g9r5qzwmwNNQ-GmkdD-T1l3a09</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Hongo, Hiroki</creator><creator>Miyawaki, Satoru</creator><creator>Imai, Hideaki</creator><creator>Shinya, Yuki</creator><creator>Ono, Hideaki</creator><creator>Mori, Harushi</creator><creator>Nakatomi, Hirofumi</creator><creator>Kunimatsu, Akira</creator><creator>Saito, Nobuhito</creator><general>Wolters Kluwer India Pvt. Ltd</general><general>Scientific Scholar</general><general>Medknow Publications & Media Pvt Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20170101</creationdate><title>Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431)</title><author>Hongo, Hiroki ; Miyawaki, Satoru ; Imai, Hideaki ; Shinya, Yuki ; Ono, Hideaki ; Mori, Harushi ; Nakatomi, Hirofumi ; Kunimatsu, Akira ; Saito, Nobuhito</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330r-6f6713e16435dafbfd38ece4e4eeb84bfbf45661054bd39f6bec4075f26cb7873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Angina pectoris</topic><topic>Atherosclerosis</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Morphology</topic><topic>Neurosurgery</topic><topic>Neurovascular: Original</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Stroke</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hongo, Hiroki</creatorcontrib><creatorcontrib>Miyawaki, Satoru</creatorcontrib><creatorcontrib>Imai, Hideaki</creatorcontrib><creatorcontrib>Shinya, Yuki</creatorcontrib><creatorcontrib>Ono, Hideaki</creatorcontrib><creatorcontrib>Mori, Harushi</creatorcontrib><creatorcontrib>Nakatomi, Hirofumi</creatorcontrib><creatorcontrib>Kunimatsu, Akira</creatorcontrib><creatorcontrib>Saito, Nobuhito</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Surgical neurology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hongo, Hiroki</au><au>Miyawaki, Satoru</au><au>Imai, Hideaki</au><au>Shinya, Yuki</au><au>Ono, Hideaki</au><au>Mori, Harushi</au><au>Nakatomi, Hirofumi</au><au>Kunimatsu, Akira</au><au>Saito, Nobuhito</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431)</atitle><jtitle>Surgical neurology international</jtitle><addtitle>Surg Neurol Int</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>8</volume><issue>1</issue><spage>104</spage><epage>104</epage><pages>104-104</pages><issn>2152-7806</issn><issn>2229-5097</issn><eissn>2152-7806</eissn><abstract>Background: Intracranial atherosclerosis (ICAS) involves diverse histologies and several remodeling patterns. Ring finger protein 213 (RNF213) c.14576G>A variant (rs112735431), recently reported to be associated with ICAS, may be linked with negative remodeling (outer diameter - reducing morphological alteration) of intracranial arteries. This study investigated the outer diameter of atherosclerotic middle cerebral artery (MCA).
Methods: Patients with unilateral atherosclerotic MCA stenosis/occlusion were enrolled in this single-hospital-based case-control study at The University of Tokyo Hospital. The patients were divided into two groups by the presence of RNF213 c.14576G>A (variant group and wild-type group) and the outer diameter of the MCA was measured with high-resolution magnetic resonance imaging.
Results: Twenty-eight patients with the wild type and 19 patients with the variant type were included. The outer diameter of the stenotic side MCA was smaller in the variant group than in the wild-type group (P = 8.3 × 10-6). The outer diameter of the normal side MCA was also smaller in the variant group than in the wild-type group (P = 5.2 × 10-3). The ratio of stenotic side to normal side was also smaller in the variant group than in the wild-type group (P = 1.5 × 10-5).
Conclusions: This study indicates that RNF213 c.14576G>A is associated with negative remodeling of ICAS.</abstract><cop>United States</cop><pub>Wolters Kluwer India Pvt. Ltd</pub><pmid>28695051</pmid><doi>10.4103/sni.sni_59_17</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Surgical neurology international, 2017-01, Vol.8 (1), p.104-104 |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Angina pectoris Atherosclerosis Deoxyribonucleic acid DNA Medical imaging Medicine Morphology Neurosurgery Neurovascular: Original NMR Nuclear magnetic resonance Stroke Veins & arteries |
| title | Smaller outer diameter of atherosclerotic middle cerebral artery associated with RNF213 c.14576G>A Variant (rs112735431) |
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