MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG
Background: Coix seed has the functions of fortifying the spleen and inhibiting the dampness. However, it remains unclear which Coix seed compositions is responsible for these functions. Previous investigations have revealed that the main compositions of Coix seed are proteins, polysaccharides, oils...
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| Veröffentlicht in: | African journal of traditional, complementary, and alternative medicines complementary, and alternative medicines, 2017, Vol.14 (4), p.239-246 |
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| container_title | African journal of traditional, complementary, and alternative medicines |
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| creator | Han, Xiaochun Ji, Xuming Zhao, Haijun Zhang, Yanan Liu, Guowei Wang, Yanfang Zhao, Wenxiao Wang, Shijun |
| description | Background: Coix seed has the functions of fortifying the spleen and
inhibiting the dampness. However, it remains unclear which Coix seed
compositions is responsible for these functions. Previous
investigations have revealed that the main compositions of Coix seed
are proteins, polysaccharides, oils and starches. The objectives of
this study are to explore which is the most effective compositions in
fortifying the spleen and examine how Coix seed works in regulating the
water transport on the spleen deficiency and wet dampness (SDWD) rat
model. Materials and Methods: The rats used were divided into (i)
control group, (ii) model group, (iii) decoction group, (iv) protein
group, (v) polysaccharide group, (vi) oil group and (vii) starch group.
The urine volume, the drinking volume and the water loading index in
each group were calculated. Agilent 8*60K array was used for
microarray-based gene expression analysis. The differential mRNAs
related to the transport activity were screened. qRT-PCR was used to
validate the mRNA microarray. Results: The results demonstrated that
all treatment groups could decrease the dampness of SDWD rats. mRNA
microarray had significant effect on the protein group and the
polysaccharide group in regulating the water transport, among which the
most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and
AQP3 respectively. Conclusion: The compositions of proteins and
polysaccharides had the most significant effect in regulating the water
transport of SDWD rat model. The contributing mRNA focused on Fabp, Slc
and AQP family. |
| doi_str_mv | 10.21010/ajtcam.v14i4.26 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5471471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1912615808</sourcerecordid><originalsourceid>FETCH-LOGICAL-b3506-46c2c20e3d0a302bb42268fdb210fd244308689c53930baadac86ca3dc40f4733</originalsourceid><addsrcrecordid>eNpVkc2P0zAQxS0EYsvCnRPykUvK-COue0GKUncbqXEqEsTHxXIcB7JKmyVpV-K_x2x3K5BGsjX-zZtnPYTeEphTAgQ-2Nujs_v5PeEdn1PxDM1oDHEEwPlzNAMil5EAIq7Qq2m6BWCS0MVLdEWlYFJKMUM2V-km0VmZl7hY47TIvuJSqVW45buizKqs0CXONK42ClefVFLlSld_0XK3VUrjlVpnaaZ0-g0neoW_qAqvknynVVni7xulb16jF63tJ__m8bxGn9eqSjfRtrjJ0mQb1SwGEXHhqKPgWQOWAa1rTqmQbVOHj7YN5ZyBFHLpYrZkUFvbWCeFs6xxHFq-YOwafTzr3p3qvW-cPxxH25u7sdvb8bcZbGf-fzl0P82P4d7EfEFCBYH3jwLj8Ovkp6PZd5PzfW8PfjhNhiwJFSSWIAMKZ9SNwzSNvr2sIWAekjHnZMxDMoaKMPLuX3uXgacoAjA_A3U39N3BXwg3dtY8NY8uFAluKfsDMvCUqg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1912615808</pqid></control><display><type>article</type><title>MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG</title><source>MEDLINE</source><source>Bioline International</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Han, Xiaochun ; Ji, Xuming ; Zhao, Haijun ; Zhang, Yanan ; Liu, Guowei ; Wang, Yanfang ; Zhao, Wenxiao ; Wang, Shijun</creator><creatorcontrib>Han, Xiaochun ; Ji, Xuming ; Zhao, Haijun ; Zhang, Yanan ; Liu, Guowei ; Wang, Yanfang ; Zhao, Wenxiao ; Wang, Shijun</creatorcontrib><description>Background: Coix seed has the functions of fortifying the spleen and
inhibiting the dampness. However, it remains unclear which Coix seed
compositions is responsible for these functions. Previous
investigations have revealed that the main compositions of Coix seed
are proteins, polysaccharides, oils and starches. The objectives of
this study are to explore which is the most effective compositions in
fortifying the spleen and examine how Coix seed works in regulating the
water transport on the spleen deficiency and wet dampness (SDWD) rat
model. Materials and Methods: The rats used were divided into (i)
control group, (ii) model group, (iii) decoction group, (iv) protein
group, (v) polysaccharide group, (vi) oil group and (vii) starch group.
The urine volume, the drinking volume and the water loading index in
each group were calculated. Agilent 8*60K array was used for
microarray-based gene expression analysis. The differential mRNAs
related to the transport activity were screened. qRT-PCR was used to
validate the mRNA microarray. Results: The results demonstrated that
all treatment groups could decrease the dampness of SDWD rats. mRNA
microarray had significant effect on the protein group and the
polysaccharide group in regulating the water transport, among which the
most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and
AQP3 respectively. Conclusion: The compositions of proteins and
polysaccharides had the most significant effect in regulating the water
transport of SDWD rat model. The contributing mRNA focused on Fabp, Slc
and AQP family.</description><identifier>ISSN: 0189-6016</identifier><identifier>EISSN: 2505-0044</identifier><identifier>DOI: 10.21010/ajtcam.v14i4.26</identifier><identifier>PMID: 28638886</identifier><language>eng</language><publisher>Nigeria: African Ethnomedicines Network</publisher><subject>animal model ; Animals ; Aquaporin 3 - genetics ; Aquaporin 3 - metabolism ; Coix - chemistry ; Coix seed ; Drugs, Chinese Herbal - administration & dosage ; Fatty Acid-Binding Proteins - genetics ; Fatty Acid-Binding Proteins - metabolism ; Female ; Gastrointestinal Hormones - genetics ; Gastrointestinal Hormones - metabolism ; Humans ; Male ; Rats ; Rats, Wistar ; Receptors, G-Protein-Coupled - genetics ; Receptors, G-Protein-Coupled - metabolism ; Seeds - chemistry ; Spleen - drug effects ; Spleen - metabolism ; Spleen - physiopathology ; spleen deficiency and wet dampness (SDWD) ; Splenic Diseases - drug therapy ; Splenic Diseases - genetics ; Splenic Diseases - metabolism ; Splenic Diseases - physiopathology ; TCM ; Water - metabolism ; water transport</subject><ispartof>African journal of traditional, complementary, and alternative medicines, 2017, Vol.14 (4), p.239-246</ispartof><rights>Copyright 2017 - African Journal of Traditional, Complementary and Alternative Medicines</rights><rights>Copyright: © 2017 Afr. J. Traditional Complementary and Alternative Medicines 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3506-46c2c20e3d0a302bb42268fdb210fd244308689c53930baadac86ca3dc40f4733</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471471/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5471471/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27902,27903,27904,53769,53771,79172</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28638886$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Xiaochun</creatorcontrib><creatorcontrib>Ji, Xuming</creatorcontrib><creatorcontrib>Zhao, Haijun</creatorcontrib><creatorcontrib>Zhang, Yanan</creatorcontrib><creatorcontrib>Liu, Guowei</creatorcontrib><creatorcontrib>Wang, Yanfang</creatorcontrib><creatorcontrib>Zhao, Wenxiao</creatorcontrib><creatorcontrib>Wang, Shijun</creatorcontrib><title>MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG</title><title>African journal of traditional, complementary, and alternative medicines</title><addtitle>Afr J Tradit Complement Altern Med</addtitle><description>Background: Coix seed has the functions of fortifying the spleen and
inhibiting the dampness. However, it remains unclear which Coix seed
compositions is responsible for these functions. Previous
investigations have revealed that the main compositions of Coix seed
are proteins, polysaccharides, oils and starches. The objectives of
this study are to explore which is the most effective compositions in
fortifying the spleen and examine how Coix seed works in regulating the
water transport on the spleen deficiency and wet dampness (SDWD) rat
model. Materials and Methods: The rats used were divided into (i)
control group, (ii) model group, (iii) decoction group, (iv) protein
group, (v) polysaccharide group, (vi) oil group and (vii) starch group.
The urine volume, the drinking volume and the water loading index in
each group were calculated. Agilent 8*60K array was used for
microarray-based gene expression analysis. The differential mRNAs
related to the transport activity were screened. qRT-PCR was used to
validate the mRNA microarray. Results: The results demonstrated that
all treatment groups could decrease the dampness of SDWD rats. mRNA
microarray had significant effect on the protein group and the
polysaccharide group in regulating the water transport, among which the
most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and
AQP3 respectively. Conclusion: The compositions of proteins and
polysaccharides had the most significant effect in regulating the water
transport of SDWD rat model. The contributing mRNA focused on Fabp, Slc
and AQP family.</description><subject>animal model</subject><subject>Animals</subject><subject>Aquaporin 3 - genetics</subject><subject>Aquaporin 3 - metabolism</subject><subject>Coix - chemistry</subject><subject>Coix seed</subject><subject>Drugs, Chinese Herbal - administration & dosage</subject><subject>Fatty Acid-Binding Proteins - genetics</subject><subject>Fatty Acid-Binding Proteins - metabolism</subject><subject>Female</subject><subject>Gastrointestinal Hormones - genetics</subject><subject>Gastrointestinal Hormones - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Receptors, G-Protein-Coupled - genetics</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Seeds - chemistry</subject><subject>Spleen - drug effects</subject><subject>Spleen - metabolism</subject><subject>Spleen - physiopathology</subject><subject>spleen deficiency and wet dampness (SDWD)</subject><subject>Splenic Diseases - drug therapy</subject><subject>Splenic Diseases - genetics</subject><subject>Splenic Diseases - metabolism</subject><subject>Splenic Diseases - physiopathology</subject><subject>TCM</subject><subject>Water - metabolism</subject><subject>water transport</subject><issn>0189-6016</issn><issn>2505-0044</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RBI</sourceid><sourceid>EIF</sourceid><recordid>eNpVkc2P0zAQxS0EYsvCnRPykUvK-COue0GKUncbqXEqEsTHxXIcB7JKmyVpV-K_x2x3K5BGsjX-zZtnPYTeEphTAgQ-2Nujs_v5PeEdn1PxDM1oDHEEwPlzNAMil5EAIq7Qq2m6BWCS0MVLdEWlYFJKMUM2V-km0VmZl7hY47TIvuJSqVW45buizKqs0CXONK42ClefVFLlSld_0XK3VUrjlVpnaaZ0-g0neoW_qAqvknynVVni7xulb16jF63tJ__m8bxGn9eqSjfRtrjJ0mQb1SwGEXHhqKPgWQOWAa1rTqmQbVOHj7YN5ZyBFHLpYrZkUFvbWCeFs6xxHFq-YOwafTzr3p3qvW-cPxxH25u7sdvb8bcZbGf-fzl0P82P4d7EfEFCBYH3jwLj8Ovkp6PZd5PzfW8PfjhNhiwJFSSWIAMKZ9SNwzSNvr2sIWAekjHnZMxDMoaKMPLuX3uXgacoAjA_A3U39N3BXwg3dtY8NY8uFAluKfsDMvCUqg</recordid><startdate>2017</startdate><enddate>2017</enddate><creator>Han, Xiaochun</creator><creator>Ji, Xuming</creator><creator>Zhao, Haijun</creator><creator>Zhang, Yanan</creator><creator>Liu, Guowei</creator><creator>Wang, Yanfang</creator><creator>Zhao, Wenxiao</creator><creator>Wang, Shijun</creator><general>African Ethnomedicines Network</general><general>African Traditional Herbal Medicine Supporters Initiative (ATHMSI)</general><scope>RBI</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2017</creationdate><title>MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG</title><author>Han, Xiaochun ; Ji, Xuming ; Zhao, Haijun ; Zhang, Yanan ; Liu, Guowei ; Wang, Yanfang ; Zhao, Wenxiao ; Wang, Shijun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3506-46c2c20e3d0a302bb42268fdb210fd244308689c53930baadac86ca3dc40f4733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>animal model</topic><topic>Animals</topic><topic>Aquaporin 3 - genetics</topic><topic>Aquaporin 3 - metabolism</topic><topic>Coix - chemistry</topic><topic>Coix seed</topic><topic>Drugs, Chinese Herbal - administration & dosage</topic><topic>Fatty Acid-Binding Proteins - genetics</topic><topic>Fatty Acid-Binding Proteins - metabolism</topic><topic>Female</topic><topic>Gastrointestinal Hormones - genetics</topic><topic>Gastrointestinal Hormones - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Receptors, G-Protein-Coupled - genetics</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Seeds - chemistry</topic><topic>Spleen - drug effects</topic><topic>Spleen - metabolism</topic><topic>Spleen - physiopathology</topic><topic>spleen deficiency and wet dampness (SDWD)</topic><topic>Splenic Diseases - drug therapy</topic><topic>Splenic Diseases - genetics</topic><topic>Splenic Diseases - metabolism</topic><topic>Splenic Diseases - physiopathology</topic><topic>TCM</topic><topic>Water - metabolism</topic><topic>water transport</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Xiaochun</creatorcontrib><creatorcontrib>Ji, Xuming</creatorcontrib><creatorcontrib>Zhao, Haijun</creatorcontrib><creatorcontrib>Zhang, Yanan</creatorcontrib><creatorcontrib>Liu, Guowei</creatorcontrib><creatorcontrib>Wang, Yanfang</creatorcontrib><creatorcontrib>Zhao, Wenxiao</creatorcontrib><creatorcontrib>Wang, Shijun</creatorcontrib><collection>Bioline International</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Xiaochun</au><au>Ji, Xuming</au><au>Zhao, Haijun</au><au>Zhang, Yanan</au><au>Liu, Guowei</au><au>Wang, Yanfang</au><au>Zhao, Wenxiao</au><au>Wang, Shijun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG</atitle><jtitle>African journal of traditional, complementary, and alternative medicines</jtitle><addtitle>Afr J Tradit Complement Altern Med</addtitle><date>2017</date><risdate>2017</risdate><volume>14</volume><issue>4</issue><spage>239</spage><epage>246</epage><pages>239-246</pages><issn>0189-6016</issn><eissn>2505-0044</eissn><abstract>Background: Coix seed has the functions of fortifying the spleen and
inhibiting the dampness. However, it remains unclear which Coix seed
compositions is responsible for these functions. Previous
investigations have revealed that the main compositions of Coix seed
are proteins, polysaccharides, oils and starches. The objectives of
this study are to explore which is the most effective compositions in
fortifying the spleen and examine how Coix seed works in regulating the
water transport on the spleen deficiency and wet dampness (SDWD) rat
model. Materials and Methods: The rats used were divided into (i)
control group, (ii) model group, (iii) decoction group, (iv) protein
group, (v) polysaccharide group, (vi) oil group and (vii) starch group.
The urine volume, the drinking volume and the water loading index in
each group were calculated. Agilent 8*60K array was used for
microarray-based gene expression analysis. The differential mRNAs
related to the transport activity were screened. qRT-PCR was used to
validate the mRNA microarray. Results: The results demonstrated that
all treatment groups could decrease the dampness of SDWD rats. mRNA
microarray had significant effect on the protein group and the
polysaccharide group in regulating the water transport, among which the
most significant mRNA was Fabp6, Slc51a, Slc51b, Slc11a2, Slc4a10 and
AQP3 respectively. Conclusion: The compositions of proteins and
polysaccharides had the most significant effect in regulating the water
transport of SDWD rat model. The contributing mRNA focused on Fabp, Slc
and AQP family.</abstract><cop>Nigeria</cop><pub>African Ethnomedicines Network</pub><pmid>28638886</pmid><doi>10.21010/ajtcam.v14i4.26</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | African journal of traditional, complementary, and alternative medicines, 2017, Vol.14 (4), p.239-246 |
| issn | 0189-6016 2505-0044 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5471471 |
| source | MEDLINE; Bioline International; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | animal model Animals Aquaporin 3 - genetics Aquaporin 3 - metabolism Coix - chemistry Coix seed Drugs, Chinese Herbal - administration & dosage Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Female Gastrointestinal Hormones - genetics Gastrointestinal Hormones - metabolism Humans Male Rats Rats, Wistar Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Seeds - chemistry Spleen - drug effects Spleen - metabolism Spleen - physiopathology spleen deficiency and wet dampness (SDWD) Splenic Diseases - drug therapy Splenic Diseases - genetics Splenic Diseases - metabolism Splenic Diseases - physiopathology TCM Water - metabolism water transport |
| title | MECHANISMS OF COIX SEED COMPOSITIONS IN THE TREATMENT OF SPLEEN DEFICIENCY AND WET DAMPNESS ZHENG |
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