Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles

The cell membrane-coated nanoparticle is a biomimetic platform consisting of a nanoparticulate core coated with membrane derived from a cell, such as a red blood cell, platelet, or cancer cell. The cell membrane “disguise” allows the particles to be perceived by the body as the source cell by intera...

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Veröffentlicht in:Bioconjugate chemistry 2017-01, Vol.28 (1), p.23-32
Hauptverfasser: Kroll, Ashley V, Fang, Ronnie H, Zhang, Liangfang
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container_title Bioconjugate chemistry
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creator Kroll, Ashley V
Fang, Ronnie H
Zhang, Liangfang
description The cell membrane-coated nanoparticle is a biomimetic platform consisting of a nanoparticulate core coated with membrane derived from a cell, such as a red blood cell, platelet, or cancer cell. The cell membrane “disguise” allows the particles to be perceived by the body as the source cell by interacting with its surroundings using the translocated surface membrane components. The newly bestowed characteristics of the membrane-coated nanoparticle can be utilized for biological interfacing in the body, providing natural solutions to many biomedical issues. This Review will cover the interactions of these cell membrane-coated nanoparticles and their applications within three biomedical areas of interest, including (i) drug delivery, (ii) detoxification, and (iii) immune modulation.
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subjects Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - therapeutic use
Autoimmune Diseases - therapy
Bacteria - drug effects
Biomimetics
Cancer Vaccines - administration & dosage
Cell Line, Tumor
Cell Membrane
Cells
Coated Materials, Biocompatible
Drug Carriers
Humans
Membranes
Nanoparticles
Neoplasms - therapy
Rats
Wounds and Injuries - drug therapy
title Biointerfacing and Applications of Cell Membrane-Coated Nanoparticles
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