NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization
Recent reports suggest promises on using oncolytic Newcastle disease viruses (NDV) to treat different cancers, while the effects of a NDV-D90 strain on gastric cancer remain unknown. Here we showed that NDV-D90 induced gastric cancer cell apoptosis in a dose-dependent manner in 3 gastric cancer cell...
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| Veröffentlicht in: | Oncotarget 2017-05, Vol.8 (21), p.34516-34524 |
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| creator | Sui, Hong Wang, Kaibing Xie, Rui Li, Xi Li, Kunpeng Bai, Yuxian Wang, Xishan Bai, Bin Chen, Dan Li, Jiazhuang Shen, Baozhong |
| description | Recent reports suggest promises on using oncolytic Newcastle disease viruses (NDV) to treat different cancers, while the effects of a NDV-D90 strain on gastric cancer remain unknown. Here we showed that NDV-D90 induced gastric cancer cell apoptosis in a dose-dependent manner in 3 gastric cancer cell lines BGC-823, SGC-7901 and MKN-28. Pronounced reduction in cell invasion was detected in NDV-D90-treated BGC-823 and SGC-7901 cells, but not in MKN-28 cells. The increases in cell apoptosis and reduction in cell growth in NDV-D90-treated gastric cancer cells seemingly resulted from augmentation of p38 signaling and suppression of ERK1/2 and Akt signaling. In vivo, orthotopic injection of NDV-D90 impaired tumor growth and induced intratumoral necrosis. Tumor cells that had been pre-treated with NDV-D90 showed defect in development of implanted tumor. Moreover, NDV-D90 appeared to reduce gastric tumor vascularization, possibly through suppression of vascular endothelial growth factor A and Matrix Metallopeptidase 2. Together, our data suggest that NDV-D90 may have potential anti-cancer effects on gastric cancer. |
| doi_str_mv | 10.18632/oncotarget.16563 |
| format | Article |
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Here we showed that NDV-D90 induced gastric cancer cell apoptosis in a dose-dependent manner in 3 gastric cancer cell lines BGC-823, SGC-7901 and MKN-28. Pronounced reduction in cell invasion was detected in NDV-D90-treated BGC-823 and SGC-7901 cells, but not in MKN-28 cells. The increases in cell apoptosis and reduction in cell growth in NDV-D90-treated gastric cancer cells seemingly resulted from augmentation of p38 signaling and suppression of ERK1/2 and Akt signaling. In vivo, orthotopic injection of NDV-D90 impaired tumor growth and induced intratumoral necrosis. Tumor cells that had been pre-treated with NDV-D90 showed defect in development of implanted tumor. Moreover, NDV-D90 appeared to reduce gastric tumor vascularization, possibly through suppression of vascular endothelial growth factor A and Matrix Metallopeptidase 2. Together, our data suggest that NDV-D90 may have potential anti-cancer effects on gastric cancer.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.16563</identifier><identifier>PMID: 28388537</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Animals ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival ; Humans ; MAP Kinase Signaling System ; Mice ; Neoplasm Invasiveness ; Neovascularization, Pathologic - therapy ; Newcastle disease virus - growth & development ; Oncolytic Virotherapy - methods ; Research Paper ; Stomach Neoplasms - blood supply ; Stomach Neoplasms - therapy ; Xenograft Model Antitumor Assays</subject><ispartof>Oncotarget, 2017-05, Vol.8 (21), p.34516-34524</ispartof><rights>Copyright: © 2017 Sui et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c422t-1cb2a05e18c530768903fdb777826257646189d8beace1b83c475929fa1625ad3</citedby><cites>FETCH-LOGICAL-c422t-1cb2a05e18c530768903fdb777826257646189d8beace1b83c475929fa1625ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470987/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470987/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28388537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sui, Hong</creatorcontrib><creatorcontrib>Wang, Kaibing</creatorcontrib><creatorcontrib>Xie, Rui</creatorcontrib><creatorcontrib>Li, Xi</creatorcontrib><creatorcontrib>Li, Kunpeng</creatorcontrib><creatorcontrib>Bai, Yuxian</creatorcontrib><creatorcontrib>Wang, Xishan</creatorcontrib><creatorcontrib>Bai, Bin</creatorcontrib><creatorcontrib>Chen, Dan</creatorcontrib><creatorcontrib>Li, Jiazhuang</creatorcontrib><creatorcontrib>Shen, Baozhong</creatorcontrib><title>NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Recent reports suggest promises on using oncolytic Newcastle disease viruses (NDV) to treat different cancers, while the effects of a NDV-D90 strain on gastric cancer remain unknown. 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Together, our data suggest that NDV-D90 may have potential anti-cancer effects on gastric cancer.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Cell Proliferation</subject><subject>Cell Survival</subject><subject>Humans</subject><subject>MAP Kinase Signaling System</subject><subject>Mice</subject><subject>Neoplasm Invasiveness</subject><subject>Neovascularization, Pathologic - therapy</subject><subject>Newcastle disease virus - growth & development</subject><subject>Oncolytic Virotherapy - methods</subject><subject>Research Paper</subject><subject>Stomach Neoplasms - blood supply</subject><subject>Stomach Neoplasms - therapy</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUctOwzAQtBCIVqUfwAXlyCUltuPEviChlpdUlQtwtTaOkwalcbCdIvh6QltK2cuuNLuzoxmEznE0wTyh5Mo0yniwpfYTnLCEHqEhFrEICWP0-GAeoLFzb1FfLE45EadoQDjlnNF0iBaL2Ws4E1Hgura12jntgtKaD78MTBGU4LytVKCgUdoG0OS7MbS6Bq_zYA1OdTXY6gt8ZZozdFJA7fR410fo5e72efoQzp_uH6c381DFhPgQq4xAxDTmitEoTbiIaJFnadrrSwhLkzjBXOQ806A0zjhVccoEEQXgHoacjtD1lrftspXOlW68hVq2tlqB_ZQGKvkfaaqlLM1a9hZEgqc9weWOwJr3TjsvV5VTuq6h0aZzEvf-9AYK-rOKt6vKGuesLvZvcCQ3Uci_KOQmiv7m4lDf_uLXePoNs2yIYA</recordid><startdate>20170523</startdate><enddate>20170523</enddate><creator>Sui, Hong</creator><creator>Wang, Kaibing</creator><creator>Xie, Rui</creator><creator>Li, Xi</creator><creator>Li, Kunpeng</creator><creator>Bai, Yuxian</creator><creator>Wang, Xishan</creator><creator>Bai, Bin</creator><creator>Chen, Dan</creator><creator>Li, Jiazhuang</creator><creator>Shen, Baozhong</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170523</creationdate><title>NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization</title><author>Sui, Hong ; Wang, Kaibing ; Xie, Rui ; Li, Xi ; Li, Kunpeng ; Bai, Yuxian ; Wang, Xishan ; Bai, Bin ; Chen, Dan ; Li, Jiazhuang ; Shen, Baozhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-1cb2a05e18c530768903fdb777826257646189d8beace1b83c475929fa1625ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Cell Proliferation</topic><topic>Cell Survival</topic><topic>Humans</topic><topic>MAP Kinase Signaling System</topic><topic>Mice</topic><topic>Neoplasm Invasiveness</topic><topic>Neovascularization, Pathologic - therapy</topic><topic>Newcastle disease virus - growth & development</topic><topic>Oncolytic Virotherapy - methods</topic><topic>Research Paper</topic><topic>Stomach Neoplasms - blood supply</topic><topic>Stomach Neoplasms - therapy</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>online_resources</toplevel><creatorcontrib>Sui, Hong</creatorcontrib><creatorcontrib>Wang, Kaibing</creatorcontrib><creatorcontrib>Xie, Rui</creatorcontrib><creatorcontrib>Li, Xi</creatorcontrib><creatorcontrib>Li, Kunpeng</creatorcontrib><creatorcontrib>Bai, Yuxian</creatorcontrib><creatorcontrib>Wang, Xishan</creatorcontrib><creatorcontrib>Bai, Bin</creatorcontrib><creatorcontrib>Chen, Dan</creatorcontrib><creatorcontrib>Li, Jiazhuang</creatorcontrib><creatorcontrib>Shen, Baozhong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sui, Hong</au><au>Wang, Kaibing</au><au>Xie, Rui</au><au>Li, Xi</au><au>Li, Kunpeng</au><au>Bai, Yuxian</au><au>Wang, Xishan</au><au>Bai, Bin</au><au>Chen, Dan</au><au>Li, Jiazhuang</au><au>Shen, Baozhong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-05-23</date><risdate>2017</risdate><volume>8</volume><issue>21</issue><spage>34516</spage><epage>34524</epage><pages>34516-34524</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Recent reports suggest promises on using oncolytic Newcastle disease viruses (NDV) to treat different cancers, while the effects of a NDV-D90 strain on gastric cancer remain unknown. Here we showed that NDV-D90 induced gastric cancer cell apoptosis in a dose-dependent manner in 3 gastric cancer cell lines BGC-823, SGC-7901 and MKN-28. Pronounced reduction in cell invasion was detected in NDV-D90-treated BGC-823 and SGC-7901 cells, but not in MKN-28 cells. The increases in cell apoptosis and reduction in cell growth in NDV-D90-treated gastric cancer cells seemingly resulted from augmentation of p38 signaling and suppression of ERK1/2 and Akt signaling. In vivo, orthotopic injection of NDV-D90 impaired tumor growth and induced intratumoral necrosis. Tumor cells that had been pre-treated with NDV-D90 showed defect in development of implanted tumor. Moreover, NDV-D90 appeared to reduce gastric tumor vascularization, possibly through suppression of vascular endothelial growth factor A and Matrix Metallopeptidase 2. Together, our data suggest that NDV-D90 may have potential anti-cancer effects on gastric cancer.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>28388537</pmid><doi>10.18632/oncotarget.16563</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell Line, Tumor Cell Proliferation Cell Survival Humans MAP Kinase Signaling System Mice Neoplasm Invasiveness Neovascularization, Pathologic - therapy Newcastle disease virus - growth & development Oncolytic Virotherapy - methods Research Paper Stomach Neoplasms - blood supply Stomach Neoplasms - therapy Xenograft Model Antitumor Assays |
| title | NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization |
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