Notch3 overexpression enhances progression and chemoresistance of urothelial carcinoma

Abnormal activation of Notch signaling is involved in the etiology of various diseases, including cancer, but the association between Notch3 expression in urothelial cancer and clinical outcome remains unclear, and the molecular mechanisms underlying Notch3 signaling activation are not well defined....

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Veröffentlicht in:	Oncotarget 2017-05, Vol.8 (21), p.34362-34373
Hauptverfasser:	Zhang, Heng, Liu, Limei, Liu, Chungang, Pan, Jinhong, Lu, Gensheng, Zhou, Zhansong, Chen, Zhiwen, Qian, Cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Transitional Cell - metabolism Carcinoma, Transitional Cell - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cisplatin - administration & dosage Cisplatin - pharmacology Disease Progression Drug Resistance, Neoplasm Female Gene Expression Regulation, Neoplastic - drug effects Humans Male Mice Neoplasm Transplantation Prognosis Receptor, Notch3 - metabolism Research Paper Survival Analysis Up-Regulation Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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