Radiation-generated Short DNA Fragments May Perturb Non-homologous End-joining and Induce Genomic Instability

Cells exposed to densely ionizing radiation (high-LET) experience more severe biological damage than do cells exposed to sparsely ionizing radiation (low-LET). The prevailing hypothesis is that high-LET radiations induce DNA double strand-breaks (DSB) that are more complex and clustered, and are the...

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Veröffentlicht in:	JOURNAL OF RADIATION RESEARCH 2011, Vol.52 (3), p.309-319
Hauptverfasser:	Pang, Dalong, Winters, Thomas A, Jung, Mira, Purkayastha, Shubhadeep, Cavalli, Luciane R, Chasovkikh, Sergey, Haddad, Bassem R, Dritschilo, Anatoly
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atomic force microscopy DNA DNA - genetics DNA - radiation effects DNA Fragmentation - radiation effects Dose-Response Relationship, Radiation Genetic research Genomic Instability - genetics Genomic Instability - radiation effects Humans Ionizing radiation Mutation - genetics Mutation - radiation effects Radiation Dosage
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