Mesothelial‐to‐mesenchymal transition as a possible therapeutic target in peritoneal metastasis of ovarian cancer

Peritoneal dissemination is the primary metastatic route of ovarian cancer (OvCa), and is often accompanied by the accumulation of ascitic fluid. The peritoneal cavity is lined by mesothelial cells (MCs), which can be converted into carcinoma‐associated fibroblasts (CAFs) through mesothelial‐to‐mese...

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Veröffentlicht in:	The Journal of pathology 2017-06, Vol.242 (2), p.140-151
Hauptverfasser:	Rynne‐Vidal, Angela, Au‐Yeung, Chi Lam, Jiménez‐Heffernan, José A, Pérez‐Lozano, María Luisa, Cremades‐Jimeno, Lucía, Bárcena, Carmen, Cristóbal‐García, Ignacio, Fernández‐Chacón, Concepción, Yeung, Tsz Lun, Mok, Samuel C, Sandoval, Pilar, López‐Cabrera, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ascites Ascites - pathology Ascitic fluid Ascitic Fluid - pathology Bioindicators Carcinoma - pathology Carcinoma - secondary carcinoma‐associated fibroblasts Cell Line, Tumor Colonization Disease Models, Animal Epithelial Cells - pathology Epithelial-Mesenchymal Transition Female Fibroblasts Fibroblasts - pathology Gastric cancer Humans Mesenchyme mesothelial‐to‐mesenchymal transition Metastases Metastasis Mice Original Paper Original Papers Ovarian cancer Ovarian Neoplasms - complications Ovarian Neoplasms - pathology peritoneal metastasis Peritoneal Neoplasms - pathology Peritoneal Neoplasms - secondary Peritoneum Receptors, Transforming Growth Factor beta - genetics Receptors, Transforming Growth Factor beta - metabolism Ribonucleic acid RNA Sequence Analysis, RNA Signal transduction Smad protein Smad3 Protein - genetics Smad3 Protein - metabolism Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism Transforming growth factor-b Tumors
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