Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice

During aging, the levels of fibronectin in the muscle stem cell niche decline, contributing to age-related frailty, and supplementation restores youth-like muscle regeneration in mice. Age-related changes in the niche have long been postulated to impair the function of somatic stem cells. Here we de...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature medicine 2016-08, Vol.22 (8), p.897-905
Hauptverfasser:	Lukjanenko, Laura, Jung, M Juliane, Hegde, Nagabhooshan, Perruisseau-Carrier, Claire, Migliavacca, Eugenia, Rozo, Michelle, Karaz, Sonia, Jacot, Guillaume, Schmidt, Manuel, Li, Liangji, Metairon, Sylviane, Raymond, Frederic, Lee, Umji, Sizzano, Federico, Wilson, David H, Dumont, Nicolas A, Palini, Alessio, Fässler, Reinhard, Steiner, Pascal, Descombes, Patrick, Rudnicki, Michael A, Fan, Chen-Ming, von Maltzahn, Julia, Feige, Jerome N, Bentzinger, C Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	13/100 13/106 13/31 38 38/61 38/79 631/532/489 631/532/7 Adhesion Aging Aging - metabolism Animals Biomedicine Blotting, Western Cancer Research Cells Extracellular Matrix - metabolism Fibronectins Fibronectins - genetics Fibronectins - metabolism Flow Cytometry Focal Adhesion Protein-Tyrosine Kinases - metabolism Genetic aspects Growth Infectious Diseases Integrins - metabolism Metabolic Diseases Mice Molecular Medicine Muscle, Skeletal - cytology Muscle, Skeletal - metabolism Muscles Musculoskeletal system Neurosciences p38 Mitogen-Activated Protein Kinases - metabolism Polymerase Chain Reaction Properties Regeneration (Biology) Regeneration - genetics Rodents Stem Cell Niche Stem cells
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!