Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report
A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous e...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2017-06, Vol.23 (21), p.3928-3933 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Tamura, Hiromi Saiki, Hirotsugu Amano, Takahiro Yamamoto, Masashi Hayashi, Shiro Ando, Hiroka Doi, Reiko Nishida, Tsutomu Yamamoto, Katsumi Adachi, Shiro |
| description | A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens. |
| doi_str_mv | 10.3748/wjg.v23.i21.3928 |
| format | Article |
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The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v23.i21.3928</identifier><identifier>PMID: 28638233</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>Adenocarcinoma - blood ; Adenocarcinoma - diagnostic imaging ; Adenocarcinoma - pathology ; Adenocarcinoma - therapy ; Biopsy ; Carcinoembryonic Antigen - blood ; Carcinoma, Squamous Cell - blood ; Carcinoma, Squamous Cell - diagnostic imaging ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Case Report ; Cell Differentiation ; Chemoradiotherapy, Adjuvant ; Endosonography ; Epithelium - diagnostic imaging ; Epithelium - pathology ; Esophageal Mucosa - diagnostic imaging ; Esophageal Mucosa - pathology ; Esophageal Neoplasms - blood ; Esophageal Neoplasms - diagnostic imaging ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - therapy ; Esophagoscopy ; Humans ; Immunohistochemistry ; Male ; Middle Aged</subject><ispartof>World journal of gastroenterology : WJG, 2017-06, Vol.23 (21), p.3928-3933</ispartof><rights>The Author(s) 2017. 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All rights reserved. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-daa33b23695bb6264ffad82213eb52cc48e93ea4f20742a93bedb7af70306ca3</citedby><cites>FETCH-LOGICAL-c440t-daa33b23695bb6264ffad82213eb52cc48e93ea4f20742a93bedb7af70306ca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/84123X/84123X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467079/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5467079/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28638233$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tamura, Hiromi</creatorcontrib><creatorcontrib>Saiki, Hirotsugu</creatorcontrib><creatorcontrib>Amano, Takahiro</creatorcontrib><creatorcontrib>Yamamoto, Masashi</creatorcontrib><creatorcontrib>Hayashi, Shiro</creatorcontrib><creatorcontrib>Ando, Hiroka</creatorcontrib><creatorcontrib>Doi, Reiko</creatorcontrib><creatorcontrib>Nishida, Tsutomu</creatorcontrib><creatorcontrib>Yamamoto, Katsumi</creatorcontrib><creatorcontrib>Adachi, Shiro</creatorcontrib><title>Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report</title><title>World journal of gastroenterology : WJG</title><addtitle>World Journal of Gastroenterology</addtitle><description>A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.</description><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - diagnostic imaging</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - therapy</subject><subject>Biopsy</subject><subject>Carcinoembryonic Antigen - blood</subject><subject>Carcinoma, Squamous Cell - blood</subject><subject>Carcinoma, Squamous Cell - diagnostic imaging</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Case Report</subject><subject>Cell Differentiation</subject><subject>Chemoradiotherapy, Adjuvant</subject><subject>Endosonography</subject><subject>Epithelium - diagnostic imaging</subject><subject>Epithelium - pathology</subject><subject>Esophageal Mucosa - diagnostic imaging</subject><subject>Esophageal Mucosa - pathology</subject><subject>Esophageal Neoplasms - blood</subject><subject>Esophageal Neoplasms - diagnostic imaging</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - therapy</subject><subject>Esophagoscopy</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Middle Aged</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0Eokvhzgn5yCWLYzuJzQGpqsqHVIlL79bEmSSuEju1k636M_jHeNVlAV_Go3nnnRk9hLwv2V40Un16vB_2By72jpd7obl6QXacl7rgSrKXZFcy1hRa8OaCvEnpnjEuRMVfkwuuaqFysiO_blJYRhgQJmohWufDDDRENzgPq_MDdZ6uI9K0xR4sUlxcTie3zfQx_6ib582H0aU12BFnZ2GanugSwwE9xb_mwwS-o91mV9q5vseIfnV5QvCf6VUenZBGXEJc35JXPUwJ353iJbn7enN3_b24_fntx_XVbWGlZGvRAQjRclHrqm1rXsu-h07l6wW2FbdWKtQCQfacNZKDFi12bQN9wwSrLYhL8uXZdtnaGTub14kwmSW6GeKTCeDM_xXvRjOEg6lk3bBGZ4OPJ4MYHjZMq5ldsjjlOzFsyZS65HVZsrrOUvYstTGkFLE_jymZOYI0GaTJIE0GaY4gc8uHf9c7N_whlwXi5DkGPzxkUmeNZur4dMWkkrqqctRSHTPxGxXer-M</recordid><startdate>20170607</startdate><enddate>20170607</enddate><creator>Tamura, Hiromi</creator><creator>Saiki, Hirotsugu</creator><creator>Amano, Takahiro</creator><creator>Yamamoto, Masashi</creator><creator>Hayashi, Shiro</creator><creator>Ando, Hiroka</creator><creator>Doi, Reiko</creator><creator>Nishida, Tsutomu</creator><creator>Yamamoto, Katsumi</creator><creator>Adachi, Shiro</creator><general>Baishideng Publishing Group Inc</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170607</creationdate><title>Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report</title><author>Tamura, Hiromi ; Saiki, Hirotsugu ; Amano, Takahiro ; Yamamoto, Masashi ; Hayashi, Shiro ; Ando, Hiroka ; Doi, Reiko ; Nishida, Tsutomu ; Yamamoto, Katsumi ; Adachi, Shiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-daa33b23695bb6264ffad82213eb52cc48e93ea4f20742a93bedb7af70306ca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma - blood</topic><topic>Adenocarcinoma - diagnostic imaging</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - therapy</topic><topic>Biopsy</topic><topic>Carcinoembryonic Antigen - blood</topic><topic>Carcinoma, Squamous Cell - blood</topic><topic>Carcinoma, Squamous Cell - diagnostic imaging</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Case Report</topic><topic>Cell Differentiation</topic><topic>Chemoradiotherapy, Adjuvant</topic><topic>Endosonography</topic><topic>Epithelium - diagnostic imaging</topic><topic>Epithelium - pathology</topic><topic>Esophageal Mucosa - diagnostic imaging</topic><topic>Esophageal Mucosa - pathology</topic><topic>Esophageal Neoplasms - blood</topic><topic>Esophageal Neoplasms - diagnostic imaging</topic><topic>Esophageal Neoplasms - pathology</topic><topic>Esophageal Neoplasms - therapy</topic><topic>Esophagoscopy</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Middle Aged</topic><toplevel>online_resources</toplevel><creatorcontrib>Tamura, Hiromi</creatorcontrib><creatorcontrib>Saiki, Hirotsugu</creatorcontrib><creatorcontrib>Amano, Takahiro</creatorcontrib><creatorcontrib>Yamamoto, Masashi</creatorcontrib><creatorcontrib>Hayashi, Shiro</creatorcontrib><creatorcontrib>Ando, Hiroka</creatorcontrib><creatorcontrib>Doi, Reiko</creatorcontrib><creatorcontrib>Nishida, Tsutomu</creatorcontrib><creatorcontrib>Yamamoto, Katsumi</creatorcontrib><creatorcontrib>Adachi, Shiro</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tamura, Hiromi</au><au>Saiki, Hirotsugu</au><au>Amano, Takahiro</au><au>Yamamoto, Masashi</au><au>Hayashi, Shiro</au><au>Ando, Hiroka</au><au>Doi, Reiko</au><au>Nishida, Tsutomu</au><au>Yamamoto, Katsumi</au><au>Adachi, Shiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World Journal of Gastroenterology</addtitle><date>2017-06-07</date><risdate>2017</risdate><volume>23</volume><issue>21</issue><spage>3928</spage><epage>3933</epage><pages>3928-3933</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>A case of esophageal carcinoma exclusively composed of adenocarcinoma simulating an esophageal gland duct in a 61-year-old man is presented. The tumor arose as a slightly elevated lesion in the middle intrathoracic esophagus. It was almost completely overlaid with nonneoplastic stratified squamous epithelial cells. Beneath the overlying surface epithelium, an adenocarcinoma that was bilayered in structure diffusely invaded both the mucosal and submucosal layers. Although the tumor consisted exclusively of adenocarcinomatous cells, a keratinizing squamous cell carcinoma component was focally observed. The invasive carcinoma was focally continuous with the small area of the surface squamous epithelial layer, which was confirmed to be neoplastic by immunohistochemistry. Morphological and immunohistochemical examinations suggested that the adenocarcinomatous component arose from the esophageal surface epithelium and clearly differentiated into an esophageal gland duct. It is important to consider the possibility of this type of adenocarcinoma when diagnosing a ductal or glandular lesion of the esophagus in small biopsy specimens.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>28638233</pmid><doi>10.3748/wjg.v23.i21.3928</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | World journal of gastroenterology : WJG, 2017-06, Vol.23 (21), p.3928-3933 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - blood Adenocarcinoma - diagnostic imaging Adenocarcinoma - pathology Adenocarcinoma - therapy Biopsy Carcinoembryonic Antigen - blood Carcinoma, Squamous Cell - blood Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Case Report Cell Differentiation Chemoradiotherapy, Adjuvant Endosonography Epithelium - diagnostic imaging Epithelium - pathology Esophageal Mucosa - diagnostic imaging Esophageal Mucosa - pathology Esophageal Neoplasms - blood Esophageal Neoplasms - diagnostic imaging Esophageal Neoplasms - pathology Esophageal Neoplasms - therapy Esophagoscopy Humans Immunohistochemistry Male Middle Aged |
| title | Esophageal carcinoma originating in the surface epithelium with immunohistochemically proven esophageal gland duct differentiation: A case report |
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