Pleiotrophin and N-syndecan promote perineural invasion and tumor progression in an orthotopic mouse model of pancreatic cancer

AIM To detect the expression of pleiotrophin(PTN) and N-syndecan in pancreatic cancer and analyze their association with tumor progression and perineural invasion(PNI).METHODS An orthotopic mouse model of pancreatic cancer was created by injecting tumor cells subcapsularly in a root region of the pa...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2017-06, Vol.23 (21), p.3907-3914
Hauptverfasser:	Yao, Jun, Zhang, Lu-Lin, Huang, Xu-Mei, Li, Wen-Yao, Gao, She-Gan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers, Tumor - metabolism Carrier Proteins - metabolism Cell Line, Tumor Cytokines - metabolism Disease Progression Humans Immunohistochemistry Kaplan-Meier Estimate Male Mice Mice, Inbred BALB C Mice, Nude Neoplasm Invasiveness - pathology Pancreas - pathology Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Peripheral Nerves - pathology Prognosis Randomized Controlled Trial Syndecan-3 - metabolism Xenograft Model Antitumor Assays
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