Methodological Rigor in Preclinical Cardiovascular Studies: Targets to Enhance Reproducibility and Promote Research Translation

RATIONALE:Methodological sources of bias and suboptimal reporting contribute to irreproducibility in preclinical science and may negatively affect research translation. Randomization, blinding, sample size estimation, and considering sex as a biological variable are deemed crucial study design eleme...

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Veröffentlicht in:	Circulation research 2017-06, Vol.120 (12), p.1916-1926
Hauptverfasser:	Ramirez, F Daniel, Motazedian, Pouya, Jung, Richard G, Di Santo, Pietro, MacDonald, Zachary D, Moreland, Robert, Simard, Trevor, Clancy, Aisling A, Russo, Juan J, Welch, Vivian A, Wells, George A, Hibbert, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cardiovascular Diseases - pathology Cardiovascular Diseases - therapy Disease Models, Animal Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - standards Humans Integrative Physiology Reproducibility of Results Research Design - standards Translational Medical Research - methods Translational Medical Research - standards
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