Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc

Fusobacterium nucleatum is associated with colorectal cancer and promotes colonic tumor formation in preclinical models. However, fusobacteria are core members of the human oral microbiome and less prevalent in the healthy gut, raising questions about how fusobacteria localize to CRC. We identify a...

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Veröffentlicht in:	Cell host & microbe 2016-08, Vol.20 (2), p.215-225
Hauptverfasser:	Abed, Jawad, Emgård, Johanna E.M., Zamir, Gideon, Faroja, Mouhammad, Almogy, Gideon, Grenov, Amalie, Sol, Asaf, Naor, Ronit, Pikarsky, Eli, Atlan, Karine A., Mellul, Anna, Chaushu, Stella, Manson, Abigail L., Earl, Ashlee M., Ou, Nora, Brennan, Caitlin A., Garrett, Wendy S., Bachrach, Gilad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - microbiology Adenocarcinoma - pathology Adhesins, Bacterial - metabolism Animals Antigens, Tumor-Associated, Carbohydrate - metabolism Bacterial Adhesion Cell Line, Tumor Colonic Neoplasms - microbiology Colonic Neoplasms - pathology Disease Models, Animal Epithelial Cells - metabolism Epithelial Cells - microbiology Fusobacterium nucleatum - physiology Host-Pathogen Interactions Humans Lectins - metabolism Mice, Inbred BALB C Models, Biological Protein Binding
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