Poly(C)-binding protein 1 (Pcbp1) regulates skeletal muscle differentiation by modulating microRNA processing in myoblasts

Regulation of gene expression during muscle development and disease remains incompletely understood. microRNAs are a class of small non-coding RNAs that regulate gene expression and function post-transcriptionally. The poly(C)-binding protein1 (Pcbp1, hnRNP-E1, or αCP-1) is an RNA-binding protein th...

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Veröffentlicht in:	The Journal of biological chemistry 2017-06, Vol.292 (23), p.9540-9550
Hauptverfasser:	Espinoza-Lewis, Ramón A., Yang, Qiumei, Liu, Jianming, Huang, Zhan-Peng, Hu, Xiaoyun, Chen, Daiwen, Wang, Da-Zhi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Argonaute Proteins - genetics Argonaute Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cell Differentiation - physiology Cell Line Cell Proliferation - physiology Dicer DNA-Binding Proteins Gene Regulation Mice microRNA (miRNA) MicroRNAs - genetics MicroRNAs - metabolism Muscle, Skeletal - metabolism Myoblasts, Skeletal - metabolism Pcbp poly(C)-binding proteins RNA RNA Processing, Post-Transcriptional - physiology RNA Stability - physiology RNA-binding protein RNA-Binding Proteins Signal Transduction - physiology skeletal muscle
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