Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cells

The immunoglobulin heavy-chain (IgH) locus undergoes large-scale contraction in B cells poised to undergo IgH V(D)J recombination. We considered the possibility that looping of distinct IgH V regions plays a role in promoting long-range interactions. Here, we simultaneously visualize three subregion...

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Veröffentlicht in:	Genes & development 2005-02, Vol.19 (3), p.322-327
Hauptverfasser:	Sayegh, Camil E, Sayegh, Camil, Jhunjhunwala, Suchit, Riblet, Roy, Murre, Cornelis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - immunology Cell Differentiation - immunology Genes, Immunoglobulin Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - immunology Immunoglobulin Variable Region - genetics Mice Research Communications
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