Ccl5 establishes an autocrine high-grade glioma growth regulatory circuit critical for mesenchymal glioblastoma survival

Glioblastoma (GBM) is the most common malignant brain tumor in adults, with a median survival of 15 months. These poor clinical outcomes have prompted the development of drugs that block neoplastic cancer cell growth; however, non-neoplastic cell-derived signals (chemokines and cytokines) in the tum...

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Veröffentlicht in:	Oncotarget 2017-05, Vol.8 (20), p.32977-32989
Hauptverfasser:	Pan, Yuan, Smithson, Laura J, Ma, Yu, Hambardzumyan, Dolores, Gutmann, David H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - metabolism Cell Line, Tumor Cell Proliferation Chemokine CCL5 - metabolism Gene Expression Regulation, Neoplastic Glioblastoma - metabolism Humans Mice Neoplasm Transplantation Neurofibromin 1 - metabolism Research Paper Signal Transduction Tumor Microenvironment
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