Correlation of mammographic density and serum calcium levels in patients with primary breast cancer
Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study invest...
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| Veröffentlicht in: | Cancer medicine (Malden, MA) MA), 2017-06, Vol.6 (6), p.1473-1481 |
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| creator | Hack, Carolin C. Stoll, Martin J. Jud, Sebastian M. Heusinger, Katharina Adler, Werner Haeberle, Lothar Ganslandt, Thomas Heindl, Felix Schulz‐Wendtland, Rüdiger Cavallaro, Alexander Uder, Michael Beckmann, Matthias W. Fasching, Peter A. Bayer, Christian M. |
| description | Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included. PMD was assessed, using a semiautomated method by two readers. Linear regression analyses were conducted to investigate the impact on PMD of the parameters of serum calcium level adjusted for albumin level, and well‐known clinical predictors such as age, body mass index (BMI), menopausal status and confounder for serum calcium like season in which the BC was diagnosed. Increased calcium levels were associated with reduced PMD (P = 0.024). Furthermore, PMD was inversely associated with BMI (P |
| doi_str_mv | 10.1002/cam4.1066 |
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Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). In this study the association between serum calcium level and PMD was assessed. We observed an inverse association for serum calcium levels adjusted for albumin level and PMD. These results add to recently published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.</description><identifier>ISSN: 2045-7634</identifier><identifier>EISSN: 2045-7634</identifier><identifier>DOI: 10.1002/cam4.1066</identifier><identifier>PMID: 28464481</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Aged ; Albumin ; Bisphosphonates ; Body mass index ; Breast cancer ; breast cancer prevention ; Breast Density ; Breast Neoplasms - blood ; Breast Neoplasms - diagnostic imaging ; Calcium ; Calcium - blood ; Cancer Prevention ; Female ; Health risk assessment ; Humans ; mammographic density ; Mammography ; menopausal status ; Middle Aged ; Monoclonal antibodies ; Original Research ; Risk factors ; Signal transduction ; Studies ; Targeted cancer therapy ; TRANCE protein ; Vitamin D</subject><ispartof>Cancer medicine (Malden, MA), 2017-06, Vol.6 (6), p.1473-1481</ispartof><rights>2017 The Authors. published by John Wiley & Sons Ltd.</rights><rights>2017 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4436-c23c342d59df4436bb9b6cfc03da5de6e9fb06f0dbabe76fbe4dec454683b27c3</citedby><cites>FETCH-LOGICAL-c4436-c23c342d59df4436bb9b6cfc03da5de6e9fb06f0dbabe76fbe4dec454683b27c3</cites><orcidid>0000-0003-4885-8471 ; 0000-0003-4019-9328</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463083/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5463083/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1411,11541,27901,27902,45550,45551,46027,46451,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28464481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hack, Carolin C.</creatorcontrib><creatorcontrib>Stoll, Martin J.</creatorcontrib><creatorcontrib>Jud, Sebastian M.</creatorcontrib><creatorcontrib>Heusinger, Katharina</creatorcontrib><creatorcontrib>Adler, Werner</creatorcontrib><creatorcontrib>Haeberle, Lothar</creatorcontrib><creatorcontrib>Ganslandt, Thomas</creatorcontrib><creatorcontrib>Heindl, Felix</creatorcontrib><creatorcontrib>Schulz‐Wendtland, Rüdiger</creatorcontrib><creatorcontrib>Cavallaro, Alexander</creatorcontrib><creatorcontrib>Uder, Michael</creatorcontrib><creatorcontrib>Beckmann, Matthias W.</creatorcontrib><creatorcontrib>Fasching, Peter A.</creatorcontrib><creatorcontrib>Bayer, Christian M.</creatorcontrib><title>Correlation of mammographic density and serum calcium levels in patients with primary breast cancer</title><title>Cancer medicine (Malden, MA)</title><addtitle>Cancer Med</addtitle><description>Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included. PMD was assessed, using a semiautomated method by two readers. Linear regression analyses were conducted to investigate the impact on PMD of the parameters of serum calcium level adjusted for albumin level, and well‐known clinical predictors such as age, body mass index (BMI), menopausal status and confounder for serum calcium like season in which the BC was diagnosed. Increased calcium levels were associated with reduced PMD (P = 0.024). Furthermore, PMD was inversely associated with BMI (P < 0.001) and age (P < 0.001). There was also an association between PMD and menopausal status (P < 0.001). The goodness‐of‐fit of the regression model was moderate. This is the first study assessing the association between serum calcium level and PMD. An inverse association with adjusted serum calcium levels was observed. These findings add to previously published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.
Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). In this study the association between serum calcium level and PMD was assessed. We observed an inverse association for serum calcium levels adjusted for albumin level and PMD. These results add to recently published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.</description><subject>Aged</subject><subject>Albumin</subject><subject>Bisphosphonates</subject><subject>Body mass index</subject><subject>Breast cancer</subject><subject>breast cancer prevention</subject><subject>Breast Density</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - diagnostic imaging</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Cancer Prevention</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>mammographic density</subject><subject>Mammography</subject><subject>menopausal status</subject><subject>Middle Aged</subject><subject>Monoclonal antibodies</subject><subject>Original Research</subject><subject>Risk factors</subject><subject>Signal transduction</subject><subject>Studies</subject><subject>Targeted cancer therapy</subject><subject>TRANCE protein</subject><subject>Vitamin D</subject><issn>2045-7634</issn><issn>2045-7634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9LHDEYxkOxVLEe-gVKwIsetubfZGYugizVFiy9tOeQP--4kUyyJjPKfvtm3a1oobm8IfnlxxMehD5R8oUSwi6sHkXdSfkOHTEimkUruTh4tT9EJ6Xck7pawmRLP6BD1gkpREePkF2mnCHoyaeI04BHPY7pLuv1ylvsIBY_bbCODhfI84itDtbXGeARQsE-4nV9CnEq-MlPK7zOftR5g00GXaaKRwv5I3o_6FDgZD-P0e_rr7-W3xa3P2--L69uF1YILheWccsFc03vhu2BMb2RdrCEO904kNAPhsiBOKMNtHIwIBxY0QjZccNay4_R5c67ns0IztZYWQe1z6SS9urtTfQrdZceVVVw0vEqONsLcnqYoUxq9MVCCDpCmouiXS962rCWVvT0H_Q-zTnW7ynaE9kR2RNWqfMdZXMqJcPwEoYStW1PbdtT2_Yq-_l1-hfyb1cVuNgBTz7A5v8mtbz6IZ6VfwAFaKZz</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Hack, Carolin C.</creator><creator>Stoll, Martin J.</creator><creator>Jud, Sebastian M.</creator><creator>Heusinger, Katharina</creator><creator>Adler, Werner</creator><creator>Haeberle, Lothar</creator><creator>Ganslandt, Thomas</creator><creator>Heindl, Felix</creator><creator>Schulz‐Wendtland, Rüdiger</creator><creator>Cavallaro, Alexander</creator><creator>Uder, Michael</creator><creator>Beckmann, Matthias W.</creator><creator>Fasching, Peter A.</creator><creator>Bayer, Christian M.</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4885-8471</orcidid><orcidid>https://orcid.org/0000-0003-4019-9328</orcidid></search><sort><creationdate>201706</creationdate><title>Correlation of mammographic density and serum calcium levels in patients with primary breast cancer</title><author>Hack, Carolin C. ; Stoll, Martin J. ; Jud, Sebastian M. ; Heusinger, Katharina ; Adler, Werner ; Haeberle, Lothar ; Ganslandt, Thomas ; Heindl, Felix ; Schulz‐Wendtland, Rüdiger ; Cavallaro, Alexander ; Uder, Michael ; Beckmann, Matthias W. ; Fasching, Peter A. ; Bayer, Christian M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4436-c23c342d59df4436bb9b6cfc03da5de6e9fb06f0dbabe76fbe4dec454683b27c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Albumin</topic><topic>Bisphosphonates</topic><topic>Body mass index</topic><topic>Breast cancer</topic><topic>breast cancer prevention</topic><topic>Breast Density</topic><topic>Breast Neoplasms - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancer medicine (Malden, MA)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hack, Carolin C.</au><au>Stoll, Martin J.</au><au>Jud, Sebastian M.</au><au>Heusinger, Katharina</au><au>Adler, Werner</au><au>Haeberle, Lothar</au><au>Ganslandt, Thomas</au><au>Heindl, Felix</au><au>Schulz‐Wendtland, Rüdiger</au><au>Cavallaro, Alexander</au><au>Uder, Michael</au><au>Beckmann, Matthias W.</au><au>Fasching, Peter A.</au><au>Bayer, Christian M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of mammographic density and serum calcium levels in patients with primary breast cancer</atitle><jtitle>Cancer medicine (Malden, MA)</jtitle><addtitle>Cancer Med</addtitle><date>2017-06</date><risdate>2017</risdate><volume>6</volume><issue>6</issue><spage>1473</spage><epage>1481</epage><pages>1473-1481</pages><issn>2045-7634</issn><eissn>2045-7634</eissn><abstract>Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included. PMD was assessed, using a semiautomated method by two readers. Linear regression analyses were conducted to investigate the impact on PMD of the parameters of serum calcium level adjusted for albumin level, and well‐known clinical predictors such as age, body mass index (BMI), menopausal status and confounder for serum calcium like season in which the BC was diagnosed. Increased calcium levels were associated with reduced PMD (P = 0.024). Furthermore, PMD was inversely associated with BMI (P < 0.001) and age (P < 0.001). There was also an association between PMD and menopausal status (P < 0.001). The goodness‐of‐fit of the regression model was moderate. This is the first study assessing the association between serum calcium level and PMD. An inverse association with adjusted serum calcium levels was observed. These findings add to previously published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.
Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). In this study the association between serum calcium level and PMD was assessed. We observed an inverse association for serum calcium levels adjusted for albumin level and PMD. These results add to recently published data relating to vitamin D, bisphosphonates, denosumab, and the RANK/RANKL signaling pathway in breast cancer risk and prevention.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>28464481</pmid><doi>10.1002/cam4.1066</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4885-8471</orcidid><orcidid>https://orcid.org/0000-0003-4019-9328</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Albumin Bisphosphonates Body mass index Breast cancer breast cancer prevention Breast Density Breast Neoplasms - blood Breast Neoplasms - diagnostic imaging Calcium Calcium - blood Cancer Prevention Female Health risk assessment Humans mammographic density Mammography menopausal status Middle Aged Monoclonal antibodies Original Research Risk factors Signal transduction Studies Targeted cancer therapy TRANCE protein Vitamin D |
| title | Correlation of mammographic density and serum calcium levels in patients with primary breast cancer |
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