Methionine tumor starvation by erythrocyte‐encapsulated methionine gamma‐lyase activity controlled with per os vitamin B6

Erymet is a new therapy resulting from the encapsulation of a methionine gamma‐lyase (MGL; EC number 4.4.1.11) in red blood cells (RBC). The aim of this study was to evaluate erymet potential efficacy in methionine (Met)‐dependent cancers. We produced a highly purified MGL using a cGMP process, dete...

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Veröffentlicht in:	Cancer medicine (Malden, MA) MA), 2017-06, Vol.6 (6), p.1437-1452
Hauptverfasser:	Gay, Fabien, Aguera, Karine, Sénéchal, Karine, Tainturier, Angie, Berlier, Willy, Maucort‐Boulch, Delphine, Honnorat, Jérôme, Horand, Françoise, Godfrin, Yann, Bourgeaux, Vanessa
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - therapeutic use Antineoplastic Agents - toxicity Bioavailability Brain cancer Cancer Biology Cancer therapies Carbon-Sulfur Lyases - administration & dosage Carbon-Sulfur Lyases - pharmacokinetics Carbon-Sulfur Lyases - therapeutic use Carbon-Sulfur Lyases - toxicity Cell cycle Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Clinical trials Cyclic GMP Cytotoxicity Diet DNA methylation Drug Delivery Systems Drug dosages Encapsulation Enzymes Erymet Erythrocytes Glioblastoma Glioblastoma cells Hemoglobin Humans Intravenous administration Laboratories Life Sciences Male Metabolism Methionine Methionine - blood Methionine - metabolism methionine gamma‐lyase methionine‐dependent cancers Mice, Nude Neoplasms - blood Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Nutrition research Oral administration Original Research Parenteral nutrition Pharmacodynamics Pharmacokinetics Plasma pyridoxal 5′‐phosphate Pyridoxal Phosphate - blood Pyridoxine Pyridoxine - administration & dosage Pyridoxine - pharmacokinetics Pyridoxine - therapeutic use Pyridoxine - toxicity Recombinant Proteins - administration & dosage Recombinant Proteins - therapeutic use Recombinant Proteins - toxicity red blood cells Starvation Studies Tumor Burden - drug effects Tumor cell lines Tumors Vitamin B6 Xenografts
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