Inhibition of Cytochrome P450 Enzymes by Quinones and Anthraquinones

In silico docking studies and quantitative structure–activity relationship analysis of a number of in-house cytochrome P450 inhibitors have revealed important structural characteristics that are required for a molecule to function as a good inhibitor of P450 enzymes 1A1, 1A2, 2B1, and/or 2A6. These...

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Veröffentlicht in:	Chemical research in toxicology 2012-02, Vol.25 (2), p.357-365
Hauptverfasser:	Sridhar, Jayalakshmi, Liu, Jiawang, Foroozesh, Maryam, Klein Stevens, Cheryl L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytochrome P-450 Enzyme Inhibitors Enzyme Inhibitors - pharmacology Humans NADP - pharmacology Quinones - pharmacology Rats Rheum
Online-Zugang:	Volltext
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