APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability

XRCC1 protein is essential for mammalian viability and is required for the efficient repair of single strand breaks (SSBs) and damaged bases in DNA. XRCC1-deficient cells are genetically unstable and sensitive to DNA damaging agents. XRCC1 has no known enzymatic activity and is thought to act as a s...

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Veröffentlicht in:	Nucleic acids research 2005-01, Vol.33 (1), p.298-306
Hauptverfasser:	Sossou, Marguerite, Flohr-Beckhaus, Claudia, Schulz, Ina, Daboussi, Fayza, Epe, Bernd, Radicella, J. Pablo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylating Agents - pharmacology Animals CHO Cells Cricetinae Cricetulus DNA Damage DNA Repair DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism DNA-Binding Proteins - genetics Gene Deletion Genomic Instability Life Sciences Oxidation-Reduction X-ray Repair Cross Complementing Protein 1
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