Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial
Background: The role of thyroid hormones in diet-induced weight loss and subsequent weight regain is largely unknown. Objectives: To examine the associations between thyroid hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting. Subjects/Methods:...
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| Veröffentlicht in: | International Journal of Obesity 2017-06, Vol.41 (6), p.878-886 |
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| creator | Liu, G Liang, L Bray, G A Qi, L Hu, F B Rood, J Sacks, F M Sun, Q |
| description | Background:
The role of thyroid hormones in diet-induced weight loss and subsequent weight regain is largely unknown.
Objectives:
To examine the associations between thyroid hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting.
Subjects/Methods:
Data analysis was conducted among 569 overweight and obese participants aged 30–70 years with normal thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months.
Results:
Participants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (
P |
| doi_str_mv | 10.1038/ijo.2017.28 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5461198</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A689284869</galeid><sourcerecordid>A689284869</sourcerecordid><originalsourceid>FETCH-LOGICAL-c625t-bb300dc1ca578f623db53e4379b888baa2a6ab426183144591cffb4bb4fb77063</originalsourceid><addsrcrecordid>eNqFktuLEzEUxgdR3Lr65LsEBBG0NfeLD8KyXqFYYbvPIZnJdFKmk26SKgX_eNPt7tIVqRBIwvnx5ZwvX1U9R3CCIJHv_DJMMERiguWDaoSo4GNGlXhYjSCBYgwZZyfVk5SWEELGIH5cnWCJSFlkVP2ed9sYfAO6EFdhcAmYoQF1Z4ZFOfsB2NBswS_nF12-Lq1cNjb0vgZrE025uXjNRZfWYUgO5HCL9yEl0HiX03uQOwd-zC6_f7wA09nFHOToTf-0etSaPrlnN_tpdfn50_z863g6-_Lt_Gw6rjlmeWwtgbCpUW2YkC3HpLGMOEqEslJKaww23FiKOZIEUcoUqtvWUmtpa4WAnJxWH_a6641duaZ2Q46m1-voVyZudTBe368MvtOL8FMzyhFSsgi8vhGI4WrjUtYrn2rX92ZwYZM0UghxpChR_0clJxjJ0mRBX_6FLsMmDsUJXWZhDCsF2TEKKbjrj_ADrYXpnfZDG8og9e5pfcalwpJKro5SVFEqlBC0UK8OqM6ZPncp9JvsywfflzsKHiq-2YN1LJmIrr3zHkG9C7EuIda7EGu8c_vF4XfdsbepLcDbPZBKqQQ1HljyD70_hAD3uQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1906119361</pqid></control><display><type>article</type><title>Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>Nature</source><creator>Liu, G ; Liang, L ; Bray, G A ; Qi, L ; Hu, F B ; Rood, J ; Sacks, F M ; Sun, Q</creator><creatorcontrib>Liu, G ; Liang, L ; Bray, G A ; Qi, L ; Hu, F B ; Rood, J ; Sacks, F M ; Sun, Q</creatorcontrib><description>Background:
The role of thyroid hormones in diet-induced weight loss and subsequent weight regain is largely unknown.
Objectives:
To examine the associations between thyroid hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting.
Subjects/Methods:
Data analysis was conducted among 569 overweight and obese participants aged 30–70 years with normal thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months.
Results:
Participants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (
P
<0.05) after multivariate adjustments including dietary intervention groups and baseline body weight. Comparing extreme tertiles, the multivariate-adjusted weight loss±s.e. was −3.87±0.9 vs −5.39±0.9 kg for free T3 (
P
trend
=0.02) and −4.09±0.9 vs −5.88±0.9 kg for free T4 (
P
trend
=0.004). The thyroid hormones did not predict weight regain in 6–24 months. A similar pattern of associations was also observed between baseline thyroid hormones and changes in RMR. In addition, changes in free T3 and total T3 levels were positively associated with changes in body weight, RMR, body fat mass, blood pressure, glucose, insulin, triglycerides and leptin at 6 months and 24 months (all
P
<0.05).
Conclusions:
In this diet-induced weight loss setting, higher baseline free T3 and free T4 predicted more weight loss, but not weight regain among overweight and obese adults with normal thyroid function. These findings reveal a novel role of thyroid hormones in body weight regulation and may help identify individuals more responsive to weight loss diets.</description><identifier>ISSN: 0307-0565</identifier><identifier>EISSN: 1476-5497</identifier><identifier>DOI: 10.1038/ijo.2017.28</identifier><identifier>PMID: 28138133</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45/776/1180 ; 692/163 ; 692/308/174 ; 692/308/2779/777 ; 692/699/2743/393 ; 692/700/2814 ; Adult ; Aged ; Blood pressure ; Body fat ; Body Mass Index ; Body size ; Body weight ; Body weight changes ; Body weight loss ; Body Weight Maintenance ; Caloric Restriction ; Cardiovascular disease ; Clinical trials ; Comparative analysis ; Data analysis ; Diabetes ; Diet ; Diet, Reducing ; Energy Metabolism - physiology ; Epidemiology ; Female ; Health aspects ; Health Promotion and Disease Prevention ; Hormones ; Humans ; Insulin ; Internal Medicine ; Laboratory tests ; Leptin ; Leptin - blood ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic rate ; Metabolism ; Methods ; Middle Aged ; Multivariate analysis ; Nutrition research ; Obesity ; original-article ; Overweight ; Overweight - blood ; Overweight - diet therapy ; Overweight - physiopathology ; Parameters ; Planning ; Prevention ; Public Health ; Reducing diets ; Thyroid ; Thyroid gland ; Thyroid hormones ; Thyroid Hormones - blood ; Thyroid-stimulating hormone ; Thyroxine ; Triglycerides ; Triiodothyronine ; Waist Circumference ; Weight control ; Weight gain ; Weight loss ; Weight Loss - physiology</subject><ispartof>International Journal of Obesity, 2017-06, Vol.41 (6), p.878-886</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature. 2017</rights><rights>COPYRIGHT 2017 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2017</rights><rights>Macmillan Publishers Limited, part of Springer Nature. 2017.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c625t-bb300dc1ca578f623db53e4379b888baa2a6ab426183144591cffb4bb4fb77063</citedby><cites>FETCH-LOGICAL-c625t-bb300dc1ca578f623db53e4379b888baa2a6ab426183144591cffb4bb4fb77063</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ijo.2017.28$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ijo.2017.28$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28138133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, G</creatorcontrib><creatorcontrib>Liang, L</creatorcontrib><creatorcontrib>Bray, G A</creatorcontrib><creatorcontrib>Qi, L</creatorcontrib><creatorcontrib>Hu, F B</creatorcontrib><creatorcontrib>Rood, J</creatorcontrib><creatorcontrib>Sacks, F M</creatorcontrib><creatorcontrib>Sun, Q</creatorcontrib><title>Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial</title><title>International Journal of Obesity</title><addtitle>Int J Obes</addtitle><addtitle>Int J Obes (Lond)</addtitle><description>Background:
The role of thyroid hormones in diet-induced weight loss and subsequent weight regain is largely unknown.
Objectives:
To examine the associations between thyroid hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting.
Subjects/Methods:
Data analysis was conducted among 569 overweight and obese participants aged 30–70 years with normal thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months.
Results:
Participants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (
P
<0.05) after multivariate adjustments including dietary intervention groups and baseline body weight. Comparing extreme tertiles, the multivariate-adjusted weight loss±s.e. was −3.87±0.9 vs −5.39±0.9 kg for free T3 (
P
trend
=0.02) and −4.09±0.9 vs −5.88±0.9 kg for free T4 (
P
trend
=0.004). The thyroid hormones did not predict weight regain in 6–24 months. A similar pattern of associations was also observed between baseline thyroid hormones and changes in RMR. In addition, changes in free T3 and total T3 levels were positively associated with changes in body weight, RMR, body fat mass, blood pressure, glucose, insulin, triglycerides and leptin at 6 months and 24 months (all
P
<0.05).
Conclusions:
In this diet-induced weight loss setting, higher baseline free T3 and free T4 predicted more weight loss, but not weight regain among overweight and obese adults with normal thyroid function. These findings reveal a novel role of thyroid hormones in body weight regulation and may help identify individuals more responsive to weight loss diets.</description><subject>631/45/776/1180</subject><subject>692/163</subject><subject>692/308/174</subject><subject>692/308/2779/777</subject><subject>692/699/2743/393</subject><subject>692/700/2814</subject><subject>Adult</subject><subject>Aged</subject><subject>Blood pressure</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Body weight changes</subject><subject>Body weight loss</subject><subject>Body Weight Maintenance</subject><subject>Caloric Restriction</subject><subject>Cardiovascular disease</subject><subject>Clinical trials</subject><subject>Comparative analysis</subject><subject>Data analysis</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Diet, Reducing</subject><subject>Energy Metabolism - physiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Health aspects</subject><subject>Health Promotion and Disease Prevention</subject><subject>Hormones</subject><subject>Humans</subject><subject>Insulin</subject><subject>Internal Medicine</subject><subject>Laboratory tests</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Metabolic rate</subject><subject>Metabolism</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Nutrition research</subject><subject>Obesity</subject><subject>original-article</subject><subject>Overweight</subject><subject>Overweight - blood</subject><subject>Overweight - diet therapy</subject><subject>Overweight - physiopathology</subject><subject>Parameters</subject><subject>Planning</subject><subject>Prevention</subject><subject>Public Health</subject><subject>Reducing diets</subject><subject>Thyroid</subject><subject>Thyroid gland</subject><subject>Thyroid hormones</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroid-stimulating hormone</subject><subject>Thyroxine</subject><subject>Triglycerides</subject><subject>Triiodothyronine</subject><subject>Waist Circumference</subject><subject>Weight control</subject><subject>Weight gain</subject><subject>Weight loss</subject><subject>Weight Loss - physiology</subject><issn>0307-0565</issn><issn>1476-5497</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFktuLEzEUxgdR3Lr65LsEBBG0NfeLD8KyXqFYYbvPIZnJdFKmk26SKgX_eNPt7tIVqRBIwvnx5ZwvX1U9R3CCIJHv_DJMMERiguWDaoSo4GNGlXhYjSCBYgwZZyfVk5SWEELGIH5cnWCJSFlkVP2ed9sYfAO6EFdhcAmYoQF1Z4ZFOfsB2NBswS_nF12-Lq1cNjb0vgZrE025uXjNRZfWYUgO5HCL9yEl0HiX03uQOwd-zC6_f7wA09nFHOToTf-0etSaPrlnN_tpdfn50_z863g6-_Lt_Gw6rjlmeWwtgbCpUW2YkC3HpLGMOEqEslJKaww23FiKOZIEUcoUqtvWUmtpa4WAnJxWH_a6641duaZ2Q46m1-voVyZudTBe368MvtOL8FMzyhFSsgi8vhGI4WrjUtYrn2rX92ZwYZM0UghxpChR_0clJxjJ0mRBX_6FLsMmDsUJXWZhDCsF2TEKKbjrj_ADrYXpnfZDG8og9e5pfcalwpJKro5SVFEqlBC0UK8OqM6ZPncp9JvsywfflzsKHiq-2YN1LJmIrr3zHkG9C7EuIda7EGu8c_vF4XfdsbepLcDbPZBKqQQ1HljyD70_hAD3uQ</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Liu, G</creator><creator>Liang, L</creator><creator>Bray, G A</creator><creator>Qi, L</creator><creator>Hu, F B</creator><creator>Rood, J</creator><creator>Sacks, F M</creator><creator>Sun, Q</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7TK</scope><scope>7TS</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M7P</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20170601</creationdate><title>Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial</title><author>Liu, G ; Liang, L ; Bray, G A ; Qi, L ; Hu, F B ; Rood, J ; Sacks, F M ; Sun, Q</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-bb300dc1ca578f623db53e4379b888baa2a6ab426183144591cffb4bb4fb77063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>631/45/776/1180</topic><topic>692/163</topic><topic>692/308/174</topic><topic>692/308/2779/777</topic><topic>692/699/2743/393</topic><topic>692/700/2814</topic><topic>Adult</topic><topic>Aged</topic><topic>Blood pressure</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Body weight changes</topic><topic>Body weight loss</topic><topic>Body Weight Maintenance</topic><topic>Caloric Restriction</topic><topic>Cardiovascular disease</topic><topic>Clinical trials</topic><topic>Comparative analysis</topic><topic>Data analysis</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Diet, Reducing</topic><topic>Energy Metabolism - physiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Health aspects</topic><topic>Health Promotion and Disease Prevention</topic><topic>Hormones</topic><topic>Humans</topic><topic>Insulin</topic><topic>Internal Medicine</topic><topic>Laboratory tests</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Metabolic rate</topic><topic>Metabolism</topic><topic>Methods</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Nutrition research</topic><topic>Obesity</topic><topic>original-article</topic><topic>Overweight</topic><topic>Overweight - blood</topic><topic>Overweight - diet therapy</topic><topic>Overweight - physiopathology</topic><topic>Parameters</topic><topic>Planning</topic><topic>Prevention</topic><topic>Public Health</topic><topic>Reducing diets</topic><topic>Thyroid</topic><topic>Thyroid gland</topic><topic>Thyroid hormones</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroid-stimulating hormone</topic><topic>Thyroxine</topic><topic>Triglycerides</topic><topic>Triiodothyronine</topic><topic>Waist Circumference</topic><topic>Weight control</topic><topic>Weight gain</topic><topic>Weight loss</topic><topic>Weight Loss - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, G</creatorcontrib><creatorcontrib>Liang, L</creatorcontrib><creatorcontrib>Bray, G A</creatorcontrib><creatorcontrib>Qi, L</creatorcontrib><creatorcontrib>Hu, F B</creatorcontrib><creatorcontrib>Rood, J</creatorcontrib><creatorcontrib>Sacks, F M</creatorcontrib><creatorcontrib>Sun, Q</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Physical Education Index</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Biological Science Database</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International Journal of Obesity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, G</au><au>Liang, L</au><au>Bray, G A</au><au>Qi, L</au><au>Hu, F B</au><au>Rood, J</au><au>Sacks, F M</au><au>Sun, Q</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial</atitle><jtitle>International Journal of Obesity</jtitle><stitle>Int J Obes</stitle><addtitle>Int J Obes (Lond)</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>41</volume><issue>6</issue><spage>878</spage><epage>886</epage><pages>878-886</pages><issn>0307-0565</issn><eissn>1476-5497</eissn><abstract>Background:
The role of thyroid hormones in diet-induced weight loss and subsequent weight regain is largely unknown.
Objectives:
To examine the associations between thyroid hormones and changes in body weight and resting metabolic rate (RMR) in a diet-induced weight loss setting.
Subjects/Methods:
Data analysis was conducted among 569 overweight and obese participants aged 30–70 years with normal thyroid function participating in the 2-year Prevention of Obesity Using Novel Dietary Strategies (POUNDS) LOST randomized clinical trial. Changes in body weight and RMR were assessed during the 2-year intervention. Thyroid hormones (free triiodothyronine (T3), free thyroxine (T4), total T3, total T4 and thyroid-stimulating hormone (TSH)), anthropometric measurements and biochemical parameters were assessed at baseline, 6 months and 24 months.
Results:
Participants lost an average of 6.6 kg of body weight during the first 6 months and subsequently regained an average of 2.7 kg of body weight over the remaining period from 6 to 24 months. Baseline free T3 and total T3 were positively associated, whereas free T4 was inversely associated, with baseline body weight, body mass index and RMR. Total T4 and TSH were not associated with these parameters. Higher baseline free T3 and free T4 levels were significantly associated with a greater weight loss during the first 6 months (
P
<0.05) after multivariate adjustments including dietary intervention groups and baseline body weight. Comparing extreme tertiles, the multivariate-adjusted weight loss±s.e. was −3.87±0.9 vs −5.39±0.9 kg for free T3 (
P
trend
=0.02) and −4.09±0.9 vs −5.88±0.9 kg for free T4 (
P
trend
=0.004). The thyroid hormones did not predict weight regain in 6–24 months. A similar pattern of associations was also observed between baseline thyroid hormones and changes in RMR. In addition, changes in free T3 and total T3 levels were positively associated with changes in body weight, RMR, body fat mass, blood pressure, glucose, insulin, triglycerides and leptin at 6 months and 24 months (all
P
<0.05).
Conclusions:
In this diet-induced weight loss setting, higher baseline free T3 and free T4 predicted more weight loss, but not weight regain among overweight and obese adults with normal thyroid function. These findings reveal a novel role of thyroid hormones in body weight regulation and may help identify individuals more responsive to weight loss diets.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28138133</pmid><doi>10.1038/ijo.2017.28</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-0565 |
| ispartof | International Journal of Obesity, 2017-06, Vol.41 (6), p.878-886 |
| issn | 0307-0565 1476-5497 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5461198 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | 631/45/776/1180 692/163 692/308/174 692/308/2779/777 692/699/2743/393 692/700/2814 Adult Aged Blood pressure Body fat Body Mass Index Body size Body weight Body weight changes Body weight loss Body Weight Maintenance Caloric Restriction Cardiovascular disease Clinical trials Comparative analysis Data analysis Diabetes Diet Diet, Reducing Energy Metabolism - physiology Epidemiology Female Health aspects Health Promotion and Disease Prevention Hormones Humans Insulin Internal Medicine Laboratory tests Leptin Leptin - blood Male Medicine Medicine & Public Health Metabolic Diseases Metabolic rate Metabolism Methods Middle Aged Multivariate analysis Nutrition research Obesity original-article Overweight Overweight - blood Overweight - diet therapy Overweight - physiopathology Parameters Planning Prevention Public Health Reducing diets Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - blood Thyroid-stimulating hormone Thyroxine Triglycerides Triiodothyronine Waist Circumference Weight control Weight gain Weight loss Weight Loss - physiology |
| title | Thyroid hormones and changes in body weight and metabolic parameters in response to weight loss diets: the POUNDS LOST trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T20%3A21%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Thyroid%20hormones%20and%20changes%20in%20body%20weight%20and%20metabolic%20parameters%20in%20response%20to%20weight%20loss%20diets:%20the%20POUNDS%20LOST%20trial&rft.jtitle=International%20Journal%20of%20Obesity&rft.au=Liu,%20G&rft.date=2017-06-01&rft.volume=41&rft.issue=6&rft.spage=878&rft.epage=886&rft.pages=878-886&rft.issn=0307-0565&rft.eissn=1476-5497&rft_id=info:doi/10.1038/ijo.2017.28&rft_dat=%3Cgale_pubme%3EA689284869%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1906119361&rft_id=info:pmid/28138133&rft_galeid=A689284869&rfr_iscdi=true |