Androgen signaling negatively controls group 2 innate lymphoid cells

Prevalence of asthma is higher in women than in men, but the mechanisms underlying this sex bias are unknown. Group 2 innate lymphoid cells (ILC2s) are key regulators of type 2 inflammatory responses. Here, we show that ILC2 development is greatly influenced by male sex hormones. Male mice have redu...

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Veröffentlicht in:	The Journal of experimental medicine 2017-06, Vol.214 (6), p.1581-1592
Hauptverfasser:	Laffont, Sophie, Blanquart, Eve, Savignac, Magali, Cénac, Claire, Laverny, Gilles, Metzger, Daniel, Girard, Jean-Philippe, Belz, Gabrielle T, Pelletier, Lucette, Seillet, Cyril, Guéry, Jean-Charles
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescents Allergens Androgen receptors Androgens Androgens - metabolism Androgens - pharmacology Animal tissues Animals Asthma Asthma - complications Asthma - immunology Asthma - pathology Castration Cell Proliferation - drug effects Disease Susceptibility Female Females Gender aspects Hemopoiesis Homeostasis Hormones Hypersensitivity Hypersensitivity - complications Hypersensitivity - immunology Hypersensitivity - pathology Immunity, Innate - immunology Inflammation Interleukin-33 - metabolism Life Sciences Lung - immunology Lung - pathology Lungs Lymphocyte Count Lymphocytes - immunology Lymphoid cells Male Males Mice Mice, Inbred C57BL Ovariectomy Pneumonia - complications Pneumonia - immunology Pneumonia - pathology Pyroglyphidae - immunology Receptors, Androgen - metabolism Regulators Respiratory tract Respiratory tract diseases Rodents Sex differences Sex hormones Sexism Signal Transduction Signaling
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