NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

NLRP3 is a cytosolic pattern recognition receptor that senses microbes and endogenous danger signals. Upon activation, NLRP3 forms an inflammasome with the adapter ASC, resulting in caspase-1 activation, release of proinflammatory cytokines and cell death. How NLRP3 activation is regulated by transc...

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Veröffentlicht in:	The Journal of experimental medicine 2017-06, Vol.214 (6), p.1725-1736
Hauptverfasser:	Stutz, Andrea, Kolbe, Carl-Christian, Stahl, Rainer, Horvath, Gabor L, Franklin, Bernardo S, van Ray, Olivia, Brinkschulte, Rebecca, Geyer, Matthias, Meissner, Felix, Latz, Eicke
Format:	Artikel
Sprache:	eng
Schlagworte:	Aberration Adapters Amino Acid Sequence Animals Assembly Caspase Caspase-1 Cell activation Cell death Cytokines Dephosphorylation Hazards HEK293 Cells Humans Immune response Inflammasomes Inflammasomes - metabolism Inflammation Kinases Mice Models, Biological Models, Molecular NLR Family, Pyrin Domain-Containing 3 Protein - chemistry NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pattern recognition Pattern recognition receptors Phosphorylation Phosphoserine - metabolism Protein Binding Protein Domains Protein Phosphatase 2 - metabolism Pyrin - chemistry Pyrin protein Structure-Activity Relationship Transcription activation
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