Deficiency of the Complement Regulatory Protein CD59 Accelerates the Development of Diabetes-induced Atherosclerosis in Mice

Abstract Aims Clinical and experimental evidence supports a strong link between the complement system, complement regulatory proteins and the pathogenesis of diabetes vascular complications. We previously reported that the complement regulatory protein CD59 is inactivated by glycation in humans with...

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Veröffentlicht in:	Journal of diabetes and its complications 2017-02, Vol.31 (2), p.311-317
Hauptverfasser:	Liu, Fengming, Sahoo, Rupam, Ge, Xiaowen, Wu, Lin, Ghosh, Pamela, Qin, Xuebin, Halperin, Jose A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aorta Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis Atherosclerosis - complications Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology Blood Glucose - analysis CD59 CD59 Antigens - deficiency CD59 Antigens - genetics CD59 Antigens - metabolism Complement Complement Activation - drug effects Complement Membrane Attack Complex - metabolism Crosses, Genetic Diabetes Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - complications Diabetic Angiopathies - immunology Diabetic Angiopathies - metabolism Diabetic Angiopathies - pathology Diabetic vascular complications Endocrinology & Metabolism Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Hyperglycemia Hypotheses Immunoglobulins Lipid Metabolism - drug effects Macrophage Activation - drug effects Membrane attack complex Mice, Inbred C57BL Mice, Knockout Pathogenesis Proteins Streptozocin - toxicity
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