Zinc Finger E-Box Binding Protein 2 (ZEB2) Suppress Apoptosis of Vascular Endothelial Cells Induced by High Glucose Through Mitogen-Activated Protein Kinases (MAPK) Pathway Activation

BACKGROUND Hyperglycemia has been confirmed to damage endothelial function of vascular and microvascular. The regulation of zinc finger E-box binding protein 2 (ZEB2) on vascular endothelial cells (VECs) is reported rarely. Our study investigates the role of ZEB2 on the apoptosis of VECs induced by...

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Veröffentlicht in:	Medical science monitor 2017-05, Vol.23, p.2590-2598
Hauptverfasser:	Wang, Lin-Jun, Wu, Zi-Heng, Zheng, Xiang-Tao, Long, Jian-Yun, Dong, Yang-Min, Fang, Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Apoptosis - genetics Cell Movement - drug effects Cell Proliferation - drug effects Down-Regulation - drug effects Down-Regulation - genetics Endothelial Cells - drug effects Endothelial Cells - metabolism Enzyme Activation - drug effects Glucose - toxicity Human Umbilical Vein Endothelial Cells - metabolism Humans Intracellular Space - metabolism Lab/In Vitro Research MAP Kinase Signaling System - drug effects Mitogen-Activated Protein Kinases - metabolism Phosphorylation - drug effects Plasmids - metabolism Reactive Oxygen Species - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Transfection Up-Regulation - drug effects Up-Regulation - genetics Zinc Finger E-box Binding Homeobox 2 - genetics Zinc Finger E-box Binding Homeobox 2 - metabolism
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