AML1-ETO and C-KIT Mutation/Overexpression in t(8;21) Leukemia: Implication in Stepwise Leukemogenesis and Response to Gleevec

To explore the genetic abnormalities that cooperate with AML1-ETO (AE) fusion gene to cause acute myeloid leukemia (AML) with t(8;21), we screened a number of candidate genes and identified 11 types of mutations in C-KIT gene (mC-KIT), including 6 previously undescribed ones among 26 of 54 (48.1%) c...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2005-01, Vol.102 (4), p.1104-1109
Hauptverfasser:	Wang, Yue-Ying, Zhou, Guang-Biao, Yin, Tong, Chen, Bing, Shi, Jing-Yi, Liang, Wen-Xue, Jin, Xiao-Long, You, Jian-Hua, Yang, Guang, Shen, Zhi-Xiang, Chen, Jue, Xiong, Shu-Min, Chen, Guo-Qiang, Xu, Feng, Liu, Yi-Wei, Chen, Zhu, Chen, Sai-Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Alleles Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Benzamides Biological Sciences Cell growth Child Child, Preschool Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 8 Core Binding Factor Alpha 2 Subunit Female Gene expression Genetic mutation Genetics Humans Imatinib Mesylate Leukemia Leukemia, Myeloid, Acute - drug therapy Leukemia, Myeloid, Acute - genetics Male Medical genetics Messenger RNA Middle Aged Mutation Myeloid leukemia Oncogene Proteins, Fusion - genetics Piperazines - pharmacology Pluripotent stem cells Proto-Oncogene Proteins c-kit - genetics Pyrimidines - pharmacology RUNX1 Translocation Partner 1 Protein Stem cells Transcription Factors - genetics Translocation, Genetic
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