Tumor-Localized Secretion of Soluble PD1 Enhances Oncolytic Virotherapy

Oncolytic virotherapy represents an attractive option for the treatment of a variety of aggressive or refractory tumors. While this therapy is effective at rapidly debulking directly injected tumor masses, achieving complete eradication of established disease has proven difficult. One method to over...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2017-06, Vol.77 (11), p.2952-2963
Hauptverfasser:	Bartee, Mee Y, Dunlap, Katherine M, Bartee, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor activity Cancer CD8 antigen Cell Line, Tumor Eradication Female Humans Immune checkpoint Immune response Immunoregulation Immunotherapy Inhibition Lymphocytes Lymphocytes T Melanoma, Experimental - immunology Metastases Mice Mice, Inbred C57BL Myxoma Oncolysis Oncolytic Virotherapy - methods Organs PD-1 protein Programmed Cell Death 1 Receptor - immunology Synergistic effect T cell receptors Tumor Microenvironment Tumors Viruses
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