Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors

Purpose Adenoid cystic carcinomas (ACCs) represent a heterogeneous group of chemotherapy refractory tumors, with a subset demonstrating an aggressive phenotype. We investigated the molecular underpinnings of this phenotype and assessed the Notch1 pathway as a potential therapeutic target. Methods We...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical oncology 2017-01, Vol.35 (3), p.352-360
Hauptverfasser:	Ferrarotto, Renata, Mitani, Yoshitsugu, Diao, Lixia, Guijarro, Irene, Wang, Jing, Zweidler-McKay, Patrick, Bell, Diana, William, Jr, William N, Glisson, Bonnie S, Wick, Michael J, Kapoun, Ann M, Patnaik, Amita, Eckhardt, Gail, Munster, Pamela, Faoro, Leonardo, Dupont, Jakob, Lee, J Jack, Futreal, Andrew, El-Naggar, Adel K, Heymach, John V
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Animals Antineoplastic Agents - therapeutic use Biology of Neoplasia Biomarkers, Tumor - genetics Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - mortality Bone Neoplasms - secondary Carcinoma, Adenoid Cystic - drug therapy Carcinoma, Adenoid Cystic - genetics Carcinoma, Adenoid Cystic - mortality Carcinoma, Adenoid Cystic - secondary Disease-Free Survival DNA Mutational Analysis Female Genetic Predisposition to Disease HEK293 Cells Humans Immunohistochemistry Kaplan-Meier Estimate Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - secondary Male Mice, Nude Middle Aged Molecular Targeted Therapy Mutation Phenotype Predictive Value of Tests Proportional Hazards Models Receptor, Notch1 - antagonists & inhibitors Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Retrospective Studies Risk Factors Salivary Gland Neoplasms - drug therapy Salivary Gland Neoplasms - genetics Salivary Gland Neoplasms - mortality Salivary Gland Neoplasms - pathology Time Factors Transfection Treatment Outcome Xenograft Model Antitumor Assays
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!