Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues
A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined...
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| Veröffentlicht in: | Materials 2015-01, Vol.8 (2), p.379-391 |
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| creator | Liang, Yanchao Su, Zhihui Yao, Yao Zhang, Na |
| description | A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical micelle concentration. The spherical morphology and particle size of the prepared nano-micelles were characterized by transmission electron microscopy and dynamic light scattering, respectively. Moreover, after the introduction of pH sensitive hydrazone bond, P123-DTX micelle showed a pH dependent drug release behavior. At pH 5.0 (in 48 h), the cumulative release amount of DTX were ~84.9%, which is about six times higher than that at pH 7.4. The prepared novel p123-DTX conjugates may offer a great benefit for drug delivery and controlling the drug release. |
| doi_str_mv | 10.3390/ma8020379 |
| format | Article |
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These pluronic P123-docetaxel (DTX) conjugates (P123-DTX) could form the stable drug-loaded materials that can self-assemble into the defined nano-micelles in aqueous solution because of their obvious amphiphilic property and low critical micelle concentration. The spherical morphology and particle size of the prepared nano-micelles were characterized by transmission electron microscopy and dynamic light scattering, respectively. Moreover, after the introduction of pH sensitive hydrazone bond, P123-DTX micelle showed a pH dependent drug release behavior. At pH 5.0 (in 48 h), the cumulative release amount of DTX were ~84.9%, which is about six times higher than that at pH 7.4. The prepared novel p123-DTX conjugates may offer a great benefit for drug delivery and controlling the drug release.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma8020379</identifier><identifier>PMID: 28787944</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Aqueous solutions ; Cancer ; Chemical bonds ; Clinical trials ; Conjugates ; Controlled release ; Copolymers ; Drug delivery systems ; Drugs ; Hydrazones ; Light scattering ; Micelles ; Nanostructure ; Polymers ; Tumors</subject><ispartof>Materials, 2015-01, Vol.8 (2), p.379-391</ispartof><rights>Copyright MDPI AG 2015</rights><rights>2015 by the authors; 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c535t-149bd08a6eebac90f0df43036b6608b860eaacda1aec70821c220e82da633de03</citedby><cites>FETCH-LOGICAL-c535t-149bd08a6eebac90f0df43036b6608b860eaacda1aec70821c220e82da633de03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455281/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5455281/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28787944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Yanchao</creatorcontrib><creatorcontrib>Su, Zhihui</creatorcontrib><creatorcontrib>Yao, Yao</creatorcontrib><creatorcontrib>Zhang, Na</creatorcontrib><title>Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues</title><title>Materials</title><addtitle>Materials (Basel)</addtitle><description>A novel polymer-drug conjugate was prepared by the chemical reaction between the copolymer Pluronic P123 and the docetaxel via a pH sensitive hydrazone bond. 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The prepared novel p123-DTX conjugates may offer a great benefit for drug delivery and controlling the drug release.</description><subject>Aqueous solutions</subject><subject>Cancer</subject><subject>Chemical bonds</subject><subject>Clinical trials</subject><subject>Conjugates</subject><subject>Controlled release</subject><subject>Copolymers</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Hydrazones</subject><subject>Light scattering</subject><subject>Micelles</subject><subject>Nanostructure</subject><subject>Polymers</subject><subject>Tumors</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqNkk1PFEEQhidGIwQ5-AdMJ170MNofM_1xMdFVhAQjATxPanpqoDez3Ut3D4F_T2_ADXKRulQl9eRNvZW3qt4y-kkIQz-vQFNOhTIvql1mjKyZaZqXj-adaj-lJS0lBNPcvK52uFZaldVudXMScQ0RsguehJGsD8kZ-uSyu0ZyMs0xeGfr78FihhucyCL45XwBGckvZ3GaMJEcyDeYwFsk-RLJWYbeTS7fEvDDhs8xFG4gpzghJCRHKc2Y3lSvRpgS7j_0verPwY_zxWF9_Pvn0eLrcW1b0eaaNaYfqAaJ2IM1dKTD2AgqZC8l1b2WFAHsAAzQKqo5s5xT1HwAKcSAVOxVX-5113O_wsFiuQembh3dCuJtF8B1_268u-wuwnXXNm3LNSsCHx4EYrgqh-du5dLGOngMc-qY4ao1UjbPQJUSmremUf9HpVJGN5Lpgr5_gi7DHH15WhGkkmshuCnUx3vKxpBSxHFrkdFuE5RuG5TCvnv8ky35NxbiDtluuYQ</recordid><startdate>20150123</startdate><enddate>20150123</enddate><creator>Liang, Yanchao</creator><creator>Su, Zhihui</creator><creator>Yao, Yao</creator><creator>Zhang, Na</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7QO</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150123</creationdate><title>Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues</title><author>Liang, Yanchao ; 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| source | MDPI - Multidisciplinary Digital Publishing Institute; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Aqueous solutions Cancer Chemical bonds Clinical trials Conjugates Controlled release Copolymers Drug delivery systems Drugs Hydrazones Light scattering Micelles Nanostructure Polymers Tumors |
| title | Preparation of pH Sensitive Pluronic-Docetaxel Conjugate Micelles to Balance the Stability and Controlled Release Issues |
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