Thymoquinone Defeats Diabetes-Induced Testicular Damage in Rats Targeting Antioxidant, Inflammatory and Aromatase Expression

Antioxidants have valuable effects on the process of spermatogenesis, particularly with diabetes mellitus (DM). Therefore, the present study investigated the impact and the intracellular mechanisms by which thymoquinone (TQ) works against diabetes-induced testicular deteriorations in rats. Wistar ma...

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Veröffentlicht in:	International journal of molecular sciences 2017-04, Vol.18 (5), p.919
Hauptverfasser:	Atta, Mustafa S, Almadaly, Essam A, El-Far, Ali H, Saleh, Rasha M, Assar, Doaa H, Al Jaouni, Soad K, Mousa, Shaker A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Antioxidants - metabolism Aromatase Aromatase - metabolism Benzoquinones - pharmacology Body Weight - drug effects Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - pathology Glutathione - metabolism Inflammation Injection Male Males Malondialdehyde Malondialdehyde - metabolism NF-kappa B - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Nitric-oxide synthase Oxidative Stress - drug effects Protective Agents - pharmacology Rats Rats, Wistar Reproductive system Rodents Sperm Spermatogenesis Spermatogenesis - drug effects Streptozocin Streptozocin - toxicity Superoxide dismutase Superoxide Dismutase - metabolism Testes Testis - drug effects Testis - metabolism Testis - pathology Up-Regulation - drug effects
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