Pharmacological and Toxicological Properties of the Potent Oral γ -Secretase Modulator BPN-15606

Alzheimer's disease (AD) is characterized neuropathologically by an abundance of 1) neuritic plaques, which are primarily composed of a fibrillar 42-amino-acid amyloid- peptide (A ), as well as 2) neurofibrillary tangles composed of aggregates of hyperphosporylated tau. Elevations in the concen...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2017-07, Vol.362 (1), p.31-44
Hauptverfasser:	Wagner, Steven L, Rynearson, Kevin D, Duddy, Steven K, Zhang, Can, Nguyen, Phuong D, Becker, Ann, Vo, Uyen, Masliah, Deborah, Monte, Louise, Klee, Justin B, Echmalian, Corinne M, Xia, Weiming, Quinti, Luisa, Johnson, Graham, Lin, Jiunn H, Kim, Doo Y, Mobley, William C, Rissman, Robert A, Tanzi, Rudolph E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Amyloid beta-Peptides - antagonists & inhibitors Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Animals Cells, Cultured Central Nervous System - drug effects Central Nervous System - metabolism Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacokinetics Enzyme Inhibitors - pharmacology Enzyme Inhibitors - toxicity Humans Macaca fascicularis Male Mice Mice, Inbred C57BL Mice, Transgenic Neuropharmacology Peptide Fragments - antagonists & inhibitors Peptide Fragments - genetics Peptide Fragments - metabolism Phenethylamines - pharmacology Phenethylamines - toxicity Plaque, Amyloid - drug therapy Pyridazines - pharmacology Pyridazines - toxicity Rats Rats, Sprague-Dawley tau Proteins - metabolism
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