VEGF165b Modulates Endothelial VEGFR1–STAT3 Signaling Pathway and Angiogenesis in Human and Experimental Peripheral Arterial Disease

RATIONALE:Atherosclerotic-arterial occlusions decrease tissue perfusion causing ischemia to lower limbs in patients with peripheral arterial disease (PAD). Ischemia in muscle induces an angiogenic response, but the magnitude of this response is frequently inadequate to meet tissue perfusion requirem...

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Veröffentlicht in:	Circulation research 2017-01, Vol.120 (2), p.282-295
Hauptverfasser:	Ganta, Vijay Chaitanya, Choi, Min, Kutateladze, Anna, Annex, Brian H
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative splicing Amino acids Angiogenesis Animals Arteriosclerosis Cohort Studies Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Female HEK293 Cells Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Ischemia Isoforms Male Mice Mice, 129 Strain Mice, Inbred BALB C Mice, Transgenic Monoclonal antibodies Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Perfusion Peripheral Arterial Disease - drug therapy Peripheral Arterial Disease - metabolism Protein Binding - physiology Signal transduction Signal Transduction - drug effects Signal Transduction - physiology Stat3 protein STAT3 Transcription Factor - metabolism Transcription Vascular endothelial growth factor Vascular Endothelial Growth Factor A - administration & dosage Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism
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