Diurnal regulation of RNA polymerase III transcription is under the control of both the feeding-fasting response and the circadian clock

RNA polymerase III (Pol III) synthesizes short noncoding RNAs, many of which are essential for translation. Accordingly, Pol III activity is tightly regulated with cell growth and proliferation by factors such as MYC, RB1, TRP53, and MAF1. MAF1 is a repressor of Pol III transcription whose activity...

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Veröffentlicht in:	Genome research 2017-06, Vol.27 (6), p.973-984
Hauptverfasser:	Mange, François, Praz, Viviane, Migliavacca, Eugenia, Willis, Ian M, Schütz, Frédéric, Hernandez, Nouria
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ARNTL Transcription Factors - deficiency ARNTL Transcription Factors - genetics Circadian Clocks - genetics Circadian Rhythm - genetics Eating - genetics Fasting - metabolism Gene Expression Profiling Gene Expression Regulation Liver - metabolism Mice Mice, Knockout Oligonucleotide Array Sequence Analysis Protein Binding Repressor Proteins - deficiency Repressor Proteins - genetics RNA Polymerase III - genetics RNA Polymerase III - metabolism Signal Transduction Transcription, Genetic
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