A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine
Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the p...
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| Veröffentlicht in: | Nutrients 2017-05, Vol.9 (5), p.499 |
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| creator | Andersen, Vibeke Holmskov, Uffe Sørensen, Signe Bek Jawhara, Mohamad Andersen, Karina W Bygum, Anette Hvid, Lone Grauslund, Jakob Wied, Jimmi Glerup, Henning Fredberg, Ulrich Villadsen, Jan Alexander Kjær, Søren Geill Fallingborg, Jan Moghadd, Seyed A G R Knudsen, Torben Brodersen, Jacob Frøjk, Jesper Dahlerup, Jens F Nielsen, Ole Haagen Christensen, Robin Bojesen, Anders Bo Sorensen, Grith Lykke Thiel, Steffen Færgeman, Nils J Brandslund, Ivan Stensballe, Allan Schmidt, Erik Berg Franke, Andre Ellinghaus, David Rosenstiel, Philip Raes, Jeroen Heitmann, Berit Boye, Mette Nielsen, Charlotte Lindgaard Werner, Lars Kjeldsen, Jens Ellingsen, Torkell |
| description | Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome. |
| doi_str_mv | 10.3390/nu9050499 |
| format | Article |
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Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu9050499</identifier><identifier>PMID: 28505128</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject><![CDATA[Arthritis ; Biomarkers - blood ; Body Mass Index ; Collaboration ; Communication ; Crohn's disease ; Data processing ; Decisions ; Denmark ; Diet ; Dietary Fats - administration & dosage ; Dietary Fiber - administration & dosage ; Dietary Proteins - administration & dosage ; Exercise ; Fatty Acids, Unsaturated - administration & dosage ; Feces ; Female ; Follow-Up Studies ; Gene expression ; Gene-Environment Interaction ; Genetics ; Humans ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - diagnosis ; Inflammatory Bowel Diseases - diet therapy ; Inflammatory Bowel Diseases - drug therapy ; Inflammatory diseases ; Inhibitors ; Intestine ; Intestines - metabolism ; Life Style ; Lifestyles ; Male ; Meat ; Metabolomics ; Micronutrients - administration & dosage ; Patients ; Pharmaceutical industry ; Precision Medicine ; Prospective Studies ; Proteomics ; Psoriasis ; Psoriatic arthritis ; Rheumatoid arthritis ; Smoking - therapy ; TNF inhibitors ; Tumor necrosis factor ; Tumor Necrosis Factor-alpha - antagonists & inhibitors ; Tumor necrosis factor-TNF ; Tumors ; Ulcerative colitis ; Urine ; Uveitis]]></subject><ispartof>Nutrients, 2017-05, Vol.9 (5), p.499</ispartof><rights>Copyright MDPI AG 2017</rights><rights>2017 by the authors. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-1d927864718c83a0f50815f8ccb9f1f47f3db81f1a8a7beb34c5179936a05a3b3</citedby><cites>FETCH-LOGICAL-c403t-1d927864718c83a0f50815f8ccb9f1f47f3db81f1a8a7beb34c5179936a05a3b3</cites><orcidid>0000-0003-0426-4962 ; 0000-0002-0127-2863 ; 0000-0002-9888-1955 ; 0000-0002-0338-2548 ; 0000-0001-8148-6572 ; 0000-0003-4612-8635 ; 0000-0002-2391-9445 ; 0000-0002-9281-5287</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452229/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452229/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28505128$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andersen, Vibeke</creatorcontrib><creatorcontrib>Holmskov, Uffe</creatorcontrib><creatorcontrib>Sørensen, Signe Bek</creatorcontrib><creatorcontrib>Jawhara, Mohamad</creatorcontrib><creatorcontrib>Andersen, Karina W</creatorcontrib><creatorcontrib>Bygum, Anette</creatorcontrib><creatorcontrib>Hvid, Lone</creatorcontrib><creatorcontrib>Grauslund, Jakob</creatorcontrib><creatorcontrib>Wied, Jimmi</creatorcontrib><creatorcontrib>Glerup, Henning</creatorcontrib><creatorcontrib>Fredberg, Ulrich</creatorcontrib><creatorcontrib>Villadsen, Jan Alexander</creatorcontrib><creatorcontrib>Kjær, Søren Geill</creatorcontrib><creatorcontrib>Fallingborg, Jan</creatorcontrib><creatorcontrib>Moghadd, Seyed A G R</creatorcontrib><creatorcontrib>Knudsen, Torben</creatorcontrib><creatorcontrib>Brodersen, Jacob</creatorcontrib><creatorcontrib>Frøjk, Jesper</creatorcontrib><creatorcontrib>Dahlerup, Jens F</creatorcontrib><creatorcontrib>Nielsen, Ole Haagen</creatorcontrib><creatorcontrib>Christensen, Robin</creatorcontrib><creatorcontrib>Bojesen, Anders Bo</creatorcontrib><creatorcontrib>Sorensen, Grith Lykke</creatorcontrib><creatorcontrib>Thiel, Steffen</creatorcontrib><creatorcontrib>Færgeman, Nils J</creatorcontrib><creatorcontrib>Brandslund, Ivan</creatorcontrib><creatorcontrib>Stensballe, Allan</creatorcontrib><creatorcontrib>Schmidt, Erik Berg</creatorcontrib><creatorcontrib>Franke, Andre</creatorcontrib><creatorcontrib>Ellinghaus, David</creatorcontrib><creatorcontrib>Rosenstiel, Philip</creatorcontrib><creatorcontrib>Raes, Jeroen</creatorcontrib><creatorcontrib>Heitmann, Berit</creatorcontrib><creatorcontrib>Boye, Mette</creatorcontrib><creatorcontrib>Nielsen, Charlotte Lindgaard</creatorcontrib><creatorcontrib>Werner, Lars</creatorcontrib><creatorcontrib>Kjeldsen, Jens</creatorcontrib><creatorcontrib>Ellingsen, Torkell</creatorcontrib><title>A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.</description><subject>Arthritis</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Collaboration</subject><subject>Communication</subject><subject>Crohn's disease</subject><subject>Data processing</subject><subject>Decisions</subject><subject>Denmark</subject><subject>Diet</subject><subject>Dietary Fats - administration & dosage</subject><subject>Dietary Fiber - administration & dosage</subject><subject>Dietary Proteins - administration & dosage</subject><subject>Exercise</subject><subject>Fatty Acids, Unsaturated - administration & dosage</subject><subject>Feces</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gene expression</subject><subject>Gene-Environment Interaction</subject><subject>Genetics</subject><subject>Humans</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - diagnosis</subject><subject>Inflammatory Bowel Diseases - diet therapy</subject><subject>Inflammatory Bowel Diseases - drug therapy</subject><subject>Inflammatory diseases</subject><subject>Inhibitors</subject><subject>Intestine</subject><subject>Intestines - metabolism</subject><subject>Life Style</subject><subject>Lifestyles</subject><subject>Male</subject><subject>Meat</subject><subject>Metabolomics</subject><subject>Micronutrients - administration & dosage</subject><subject>Patients</subject><subject>Pharmaceutical industry</subject><subject>Precision Medicine</subject><subject>Prospective Studies</subject><subject>Proteomics</subject><subject>Psoriasis</subject><subject>Psoriatic arthritis</subject><subject>Rheumatoid arthritis</subject><subject>Smoking - therapy</subject><subject>TNF inhibitors</subject><subject>Tumor necrosis factor</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><subject>Ulcerative colitis</subject><subject>Urine</subject><subject>Uveitis</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkt1qFDEUgAdRbKm98AUk4I1erCaTZCbxQli2tha2WGy9Hs7kp5uSSbbJjLAv6HM109almpuEnI_v_HCq6i3BnyiV-HOYJOaYSfmiOqxxWy-ahtGXz94H1XHOt3g-LW4b-ro6qAXHnNTisPqzRJcpbmMGj2xMCNDVOOkdigFdJwPjYMKIrow3anTlD4JGa2dNHnfeoJ9GxaEQGuZgRi6g1SbF4BQ6D9bDMMAY0w6duGwgm_wFLdEJBJc36GLyo9MuK7f1LkCBVtF76GN6cM35S103Ieax2E5BFVF-SH9pUo4BfHFqdGG0Uy6YN9UrCz6b46f7qPp1-u169X2x_nF2vlquF4phOi6IlnUrGtYSoQQFbDkWhFuhVC8tsay1VPeCWAIC2t70lClOWilpA5gD7elR9fXRu536wWhVppPAd9vkhtJDF8F1_0aC23Q38XfHGa_rWhbBhydBindTmWM3lCGY0nowccodEVIyzCif0ff_obdxSqXzQkmCG0woY4X6-EipFHNOxu6LIbibF6TbL0hh3z2vfk_-XQd6DyVuuo8</recordid><startdate>20170515</startdate><enddate>20170515</enddate><creator>Andersen, 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Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine</title><author>Andersen, Vibeke ; Holmskov, Uffe ; Sørensen, Signe Bek ; Jawhara, Mohamad ; Andersen, Karina W ; Bygum, Anette ; Hvid, Lone ; Grauslund, Jakob ; Wied, Jimmi ; Glerup, Henning ; Fredberg, Ulrich ; Villadsen, Jan Alexander ; Kjær, Søren Geill ; Fallingborg, Jan ; Moghadd, Seyed A G R ; Knudsen, Torben ; Brodersen, Jacob ; Frøjk, Jesper ; Dahlerup, Jens F ; Nielsen, Ole Haagen ; Christensen, Robin ; Bojesen, Anders Bo ; Sorensen, Grith Lykke ; Thiel, Steffen ; Færgeman, Nils J ; Brandslund, Ivan ; Stensballe, Allan ; Schmidt, Erik Berg ; Franke, Andre ; Ellinghaus, David ; Rosenstiel, Philip ; Raes, Jeroen ; Heitmann, Berit ; Boye, Mette ; Nielsen, Charlotte Lindgaard ; Werner, Lars ; Kjeldsen, Jens ; Ellingsen, Torkell</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-1d927864718c83a0f50815f8ccb9f1f47f3db81f1a8a7beb34c5179936a05a3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Arthritis</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Collaboration</topic><topic>Communication</topic><topic>Crohn's disease</topic><topic>Data processing</topic><topic>Decisions</topic><topic>Denmark</topic><topic>Diet</topic><topic>Dietary Fats - administration & dosage</topic><topic>Dietary Fiber - administration & dosage</topic><topic>Dietary Proteins - administration & dosage</topic><topic>Exercise</topic><topic>Fatty Acids, Unsaturated - administration & dosage</topic><topic>Feces</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gene expression</topic><topic>Gene-Environment 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Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andersen, Vibeke</au><au>Holmskov, Uffe</au><au>Sørensen, Signe Bek</au><au>Jawhara, Mohamad</au><au>Andersen, Karina W</au><au>Bygum, Anette</au><au>Hvid, Lone</au><au>Grauslund, Jakob</au><au>Wied, Jimmi</au><au>Glerup, Henning</au><au>Fredberg, Ulrich</au><au>Villadsen, Jan Alexander</au><au>Kjær, Søren Geill</au><au>Fallingborg, Jan</au><au>Moghadd, Seyed A G R</au><au>Knudsen, Torben</au><au>Brodersen, Jacob</au><au>Frøjk, Jesper</au><au>Dahlerup, Jens F</au><au>Nielsen, Ole Haagen</au><au>Christensen, Robin</au><au>Bojesen, Anders Bo</au><au>Sorensen, Grith Lykke</au><au>Thiel, Steffen</au><au>Færgeman, Nils J</au><au>Brandslund, Ivan</au><au>Stensballe, Allan</au><au>Schmidt, Erik Berg</au><au>Franke, Andre</au><au>Ellinghaus, David</au><au>Rosenstiel, Philip</au><au>Raes, Jeroen</au><au>Heitmann, Berit</au><au>Boye, Mette</au><au>Nielsen, Charlotte Lindgaard</au><au>Werner, Lars</au><au>Kjeldsen, Jens</au><au>Ellingsen, Torkell</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2017-05-15</date><risdate>2017</risdate><volume>9</volume><issue>5</issue><spage>499</spage><pages>499-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>Chronic inflammatory diseases (CIDs), including Crohn's disease and ulcerative colitis (inflammatory bowel diseases, IBD), rheumatoid arthritis, psoriasis, psoriatic arthritis, spondyloarthritides, hidradenitis suppurativa, and immune-mediated uveitis, are treated with biologics targeting the pro-inflammatory molecule tumour necrosis factor-α (TNF) (i.e., TNF inhibitors). Approximately one-third of the patients do not respond to the treatment. Genetics and lifestyle may affect the treatment results. The aims of this multidisciplinary collaboration are to identify (1) molecular signatures of prognostic value to help tailor treatment decisions to an individual likely to initiate TNF inhibitor therapy, followed by (2) lifestyle factors that support achievement of optimised treatment outcome. This report describes the establishment of a cohort that aims to obtain this information. Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy. Both hypothesis-driven and data-driven analyses will be performed according to pre-specified protocols including pathway analyses resulting from candidate gene expression analyses and global approaches (e.g., metabolomics, metagenomics, proteomics). The final purpose is to improve the lives of patients suffering from CIDs, by providing tools facilitating treatment selection and dietary recommendations likely to improve the clinical outcome.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>28505128</pmid><doi>10.3390/nu9050499</doi><orcidid>https://orcid.org/0000-0003-0426-4962</orcidid><orcidid>https://orcid.org/0000-0002-0127-2863</orcidid><orcidid>https://orcid.org/0000-0002-9888-1955</orcidid><orcidid>https://orcid.org/0000-0002-0338-2548</orcidid><orcidid>https://orcid.org/0000-0001-8148-6572</orcidid><orcidid>https://orcid.org/0000-0003-4612-8635</orcidid><orcidid>https://orcid.org/0000-0002-2391-9445</orcidid><orcidid>https://orcid.org/0000-0002-9281-5287</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6643 |
| ispartof | Nutrients, 2017-05, Vol.9 (5), p.499 |
| issn | 2072-6643 2072-6643 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5452229 |
| source | MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Arthritis Biomarkers - blood Body Mass Index Collaboration Communication Crohn's disease Data processing Decisions Denmark Diet Dietary Fats - administration & dosage Dietary Fiber - administration & dosage Dietary Proteins - administration & dosage Exercise Fatty Acids, Unsaturated - administration & dosage Feces Female Follow-Up Studies Gene expression Gene-Environment Interaction Genetics Humans Inflammatory bowel diseases Inflammatory Bowel Diseases - diagnosis Inflammatory Bowel Diseases - diet therapy Inflammatory Bowel Diseases - drug therapy Inflammatory diseases Inhibitors Intestine Intestines - metabolism Life Style Lifestyles Male Meat Metabolomics Micronutrients - administration & dosage Patients Pharmaceutical industry Precision Medicine Prospective Studies Proteomics Psoriasis Psoriatic arthritis Rheumatoid arthritis Smoking - therapy TNF inhibitors Tumor necrosis factor Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor necrosis factor-TNF Tumors Ulcerative colitis Urine Uveitis |
| title | A Proposal for a Study on Treatment Selection and Lifestyle Recommendations in Chronic Inflammatory Diseases: A Danish Multidisciplinary Collaboration on Prognostic Factors and Personalised Medicine |
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