A new sub‐pathway of long‐patch base excision repair involving 5′ gap formation

Base excision repair (BER) is one of the most frequently used cellular DNA repair mechanisms and modulates many human pathophysiological conditions related to DNA damage. Through live cell and in vitro reconstitution experiments, we have discovered a major sub‐pathway of conventional long‐patch BER...

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Veröffentlicht in:	The EMBO journal 2017-06, Vol.36 (11), p.1605-1622
Hauptverfasser:	Woodrick, Jordan, Gupta, Suhani, Camacho, Sharon, Parvathaneni, Swetha, Choudhury, Sujata, Cheema, Amrita, Bai, Yi, Khatkar, Pooja, Erkizan, Hayriye Verda, Sami, Furqan, Su, Yan, Schärer, Orlando D, Sharma, Sudha, Roy, Rabindra
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Alkylation Base excision repair BER pathway switch Cell Line Damage detection Deoxyribonucleic acid DNA DNA - metabolism DNA Damage DNA helicase DNA Repair DNA-Binding Proteins - metabolism EMBO13 Endonuclease Endonucleases - metabolism ERCC1 protein Humans In vitro methods and tests Lesions Models, Biological oxidative damage PARP inhibition Poly (ADP-Ribose) Polymerase-1 - metabolism Poly(ADP-ribose) Poly(ADP-ribose) polymerase RecQ Helicases - metabolism RECQ1 Repair Replication Protein A - metabolism Ribose XPF‐ERCC1
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