Aversive olfactory associative memory loses odor specificity over time
Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor-electric shock associative memory paradigm, we found that learned avoidance lost it...
Gespeichert in:
| Veröffentlicht in: | Journal of experimental biology 2017-05, Vol.220 (Pt 9), p.1548-1553 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1553 |
|---|---|
| container_issue | Pt 9 |
| container_start_page | 1548 |
| container_title | Journal of experimental biology |
| container_volume | 220 |
| creator | König, Christian Antwi-Adjei, Emmanuel Ganesan, Mathangi Kilonzo, Kasyoka Viswanathan, Vignesh Durairaja, Archana Voigt, Anne Yarali, Ayse |
| description | Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor-electric shock associative memory paradigm, we found that learned avoidance lost its specificity for the trained odor and became general to novel odors within a day of training. We discuss the possible neural circuit mechanisms of this effect and highlight the parallelism to over-generalization of learned fear behavior after an incubation period in rodents and humans, with due relevance for post-traumatic stress disorder. |
| doi_str_mv | 10.1242/jeb.155317 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5450803</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1895273652</sourcerecordid><originalsourceid>FETCH-LOGICAL-c472t-9a4fff268c2d370f690e7c53fe2bdafff153941ff3a4f8ecd74d83078a6fed573</originalsourceid><addsrcrecordid>eNqFkUtLAzEUhYMoWh8bf4AMuBFhNM9JshGK-ALBja5DmrnRlJmmJtNC_70pVVE33kUunPvlkNyD0DHBF4RyejmFyQURghG5hUaES1lrwsU2GmFMaY0113toP-cpLtUIvov2qOKNUoSM0O14CSmHJVSx89YNMa0qm3N0wQ5rtYd-LXUxQ65iG1OV5-CCDy4MqyqWy9UQejhEO952GY4--wF6ub15vr6vH5_uHq7Hj7Xjkg61ttx7TxvlaMsk9o3GIJ1gHuiktWVEBNOceM8KqMC1kreKYals46EVkh2gq43vfDHpoXUwG5LtzDyF3qaViTaY35NZeDOvcWkEF1hhVgzOPg1SfF9AHkwfsoOuszOIi2yIxkTycvD_UaUFlawRtKCnf9BpXKRZ2YShZeca86bBhTrfUC7FnBP473cTbNZJmpKk2SRZ4JOfP_1Gv6JjHyhXmqw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2006904660</pqid></control><display><type>article</type><title>Aversive olfactory associative memory loses odor specificity over time</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Company of Biologists</source><creator>König, Christian ; Antwi-Adjei, Emmanuel ; Ganesan, Mathangi ; Kilonzo, Kasyoka ; Viswanathan, Vignesh ; Durairaja, Archana ; Voigt, Anne ; Yarali, Ayse</creator><creatorcontrib>König, Christian ; Antwi-Adjei, Emmanuel ; Ganesan, Mathangi ; Kilonzo, Kasyoka ; Viswanathan, Vignesh ; Durairaja, Archana ; Voigt, Anne ; Yarali, Ayse</creatorcontrib><description>Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor-electric shock associative memory paradigm, we found that learned avoidance lost its specificity for the trained odor and became general to novel odors within a day of training. We discuss the possible neural circuit mechanisms of this effect and highlight the parallelism to over-generalization of learned fear behavior after an incubation period in rodents and humans, with due relevance for post-traumatic stress disorder.</description><identifier>ISSN: 0022-0949</identifier><identifier>EISSN: 1477-9145</identifier><identifier>DOI: 10.1242/jeb.155317</identifier><identifier>PMID: 28468811</identifier><language>eng</language><publisher>England: The Company of Biologists Ltd</publisher><subject>Animals ; Association Learning ; Associative memory ; Avoidance Learning ; Behavior, Animal ; Conditioning, Classical ; Cues ; Drosophila ; Drosophila melanogaster - physiology ; Female ; Fruit flies ; Fruits ; Hazards ; Learning ; Male ; Memory ; Mental disorders ; Mimicry ; Odor ; Odorants ; Odors ; Post traumatic stress disorder ; Rodents ; Short Communication ; Smell - physiology ; Time Factors</subject><ispartof>Journal of experimental biology, 2017-05, Vol.220 (Pt 9), p.1548-1553</ispartof><rights>2017. Published by The Company of Biologists Ltd.</rights><rights>Copyright The Company of Biologists Ltd May 1, 2017</rights><rights>2017. Published by The Company of Biologists Ltd 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-9a4fff268c2d370f690e7c53fe2bdafff153941ff3a4f8ecd74d83078a6fed573</citedby><cites>FETCH-LOGICAL-c472t-9a4fff268c2d370f690e7c53fe2bdafff153941ff3a4f8ecd74d83078a6fed573</cites><orcidid>0000-0002-9048-4306</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,3678,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28468811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>König, Christian</creatorcontrib><creatorcontrib>Antwi-Adjei, Emmanuel</creatorcontrib><creatorcontrib>Ganesan, Mathangi</creatorcontrib><creatorcontrib>Kilonzo, Kasyoka</creatorcontrib><creatorcontrib>Viswanathan, Vignesh</creatorcontrib><creatorcontrib>Durairaja, Archana</creatorcontrib><creatorcontrib>Voigt, Anne</creatorcontrib><creatorcontrib>Yarali, Ayse</creatorcontrib><title>Aversive olfactory associative memory loses odor specificity over time</title><title>Journal of experimental biology</title><addtitle>J Exp Biol</addtitle><description>Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor-electric shock associative memory paradigm, we found that learned avoidance lost its specificity for the trained odor and became general to novel odors within a day of training. We discuss the possible neural circuit mechanisms of this effect and highlight the parallelism to over-generalization of learned fear behavior after an incubation period in rodents and humans, with due relevance for post-traumatic stress disorder.</description><subject>Animals</subject><subject>Association Learning</subject><subject>Associative memory</subject><subject>Avoidance Learning</subject><subject>Behavior, Animal</subject><subject>Conditioning, Classical</subject><subject>Cues</subject><subject>Drosophila</subject><subject>Drosophila melanogaster - physiology</subject><subject>Female</subject><subject>Fruit flies</subject><subject>Fruits</subject><subject>Hazards</subject><subject>Learning</subject><subject>Male</subject><subject>Memory</subject><subject>Mental disorders</subject><subject>Mimicry</subject><subject>Odor</subject><subject>Odorants</subject><subject>Odors</subject><subject>Post traumatic stress disorder</subject><subject>Rodents</subject><subject>Short Communication</subject><subject>Smell - physiology</subject><subject>Time Factors</subject><issn>0022-0949</issn><issn>1477-9145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEUhYMoWh8bf4AMuBFhNM9JshGK-ALBja5DmrnRlJmmJtNC_70pVVE33kUunPvlkNyD0DHBF4RyejmFyQURghG5hUaES1lrwsU2GmFMaY0113toP-cpLtUIvov2qOKNUoSM0O14CSmHJVSx89YNMa0qm3N0wQ5rtYd-LXUxQ65iG1OV5-CCDy4MqyqWy9UQejhEO952GY4--wF6ub15vr6vH5_uHq7Hj7Xjkg61ttx7TxvlaMsk9o3GIJ1gHuiktWVEBNOceM8KqMC1kreKYals46EVkh2gq43vfDHpoXUwG5LtzDyF3qaViTaY35NZeDOvcWkEF1hhVgzOPg1SfF9AHkwfsoOuszOIi2yIxkTycvD_UaUFlawRtKCnf9BpXKRZ2YShZeca86bBhTrfUC7FnBP473cTbNZJmpKk2SRZ4JOfP_1Gv6JjHyhXmqw</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>König, Christian</creator><creator>Antwi-Adjei, Emmanuel</creator><creator>Ganesan, Mathangi</creator><creator>Kilonzo, Kasyoka</creator><creator>Viswanathan, Vignesh</creator><creator>Durairaja, Archana</creator><creator>Voigt, Anne</creator><creator>Yarali, Ayse</creator><general>The Company of Biologists Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9048-4306</orcidid></search><sort><creationdate>20170501</creationdate><title>Aversive olfactory associative memory loses odor specificity over time</title><author>König, Christian ; Antwi-Adjei, Emmanuel ; Ganesan, Mathangi ; Kilonzo, Kasyoka ; Viswanathan, Vignesh ; Durairaja, Archana ; Voigt, Anne ; Yarali, Ayse</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-9a4fff268c2d370f690e7c53fe2bdafff153941ff3a4f8ecd74d83078a6fed573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Association Learning</topic><topic>Associative memory</topic><topic>Avoidance Learning</topic><topic>Behavior, Animal</topic><topic>Conditioning, Classical</topic><topic>Cues</topic><topic>Drosophila</topic><topic>Drosophila melanogaster - physiology</topic><topic>Female</topic><topic>Fruit flies</topic><topic>Fruits</topic><topic>Hazards</topic><topic>Learning</topic><topic>Male</topic><topic>Memory</topic><topic>Mental disorders</topic><topic>Mimicry</topic><topic>Odor</topic><topic>Odorants</topic><topic>Odors</topic><topic>Post traumatic stress disorder</topic><topic>Rodents</topic><topic>Short Communication</topic><topic>Smell - physiology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>König, Christian</creatorcontrib><creatorcontrib>Antwi-Adjei, Emmanuel</creatorcontrib><creatorcontrib>Ganesan, Mathangi</creatorcontrib><creatorcontrib>Kilonzo, Kasyoka</creatorcontrib><creatorcontrib>Viswanathan, Vignesh</creatorcontrib><creatorcontrib>Durairaja, Archana</creatorcontrib><creatorcontrib>Voigt, Anne</creatorcontrib><creatorcontrib>Yarali, Ayse</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of experimental biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>König, Christian</au><au>Antwi-Adjei, Emmanuel</au><au>Ganesan, Mathangi</au><au>Kilonzo, Kasyoka</au><au>Viswanathan, Vignesh</au><au>Durairaja, Archana</au><au>Voigt, Anne</au><au>Yarali, Ayse</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aversive olfactory associative memory loses odor specificity over time</atitle><jtitle>Journal of experimental biology</jtitle><addtitle>J Exp Biol</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>220</volume><issue>Pt 9</issue><spage>1548</spage><epage>1553</epage><pages>1548-1553</pages><issn>0022-0949</issn><eissn>1477-9145</eissn><abstract>Avoiding associatively learned predictors of danger is crucial for survival. Aversive memories can, however, become counter-adaptive when they are overly generalized to harmless cues and contexts. In a fruit fly odor-electric shock associative memory paradigm, we found that learned avoidance lost its specificity for the trained odor and became general to novel odors within a day of training. We discuss the possible neural circuit mechanisms of this effect and highlight the parallelism to over-generalization of learned fear behavior after an incubation period in rodents and humans, with due relevance for post-traumatic stress disorder.</abstract><cop>England</cop><pub>The Company of Biologists Ltd</pub><pmid>28468811</pmid><doi>10.1242/jeb.155317</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-9048-4306</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-0949 |
| ispartof | Journal of experimental biology, 2017-05, Vol.220 (Pt 9), p.1548-1553 |
| issn | 0022-0949 1477-9145 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5450803 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Company of Biologists |
| subjects | Animals Association Learning Associative memory Avoidance Learning Behavior, Animal Conditioning, Classical Cues Drosophila Drosophila melanogaster - physiology Female Fruit flies Fruits Hazards Learning Male Memory Mental disorders Mimicry Odor Odorants Odors Post traumatic stress disorder Rodents Short Communication Smell - physiology Time Factors |
| title | Aversive olfactory associative memory loses odor specificity over time |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T23%3A46%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Aversive%20olfactory%20associative%20memory%20loses%20odor%20specificity%20over%20time&rft.jtitle=Journal%20of%20experimental%20biology&rft.au=K%C3%B6nig,%20Christian&rft.date=2017-05-01&rft.volume=220&rft.issue=Pt%209&rft.spage=1548&rft.epage=1553&rft.pages=1548-1553&rft.issn=0022-0949&rft.eissn=1477-9145&rft_id=info:doi/10.1242/jeb.155317&rft_dat=%3Cproquest_pubme%3E1895273652%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2006904660&rft_id=info:pmid/28468811&rfr_iscdi=true |