Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA

G-quadruplex or G4 DNA is a non-B secondary DNA structure consisting of a stacked array of guanine-quartets that can disrupt critical cellular functions such as replication and transcription. When sequences that can adopt Non-B structures including G4 DNA are located within actively transcribed gene...

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Veröffentlicht in:	Nucleic acids research 2017-06, Vol.45 (10), p.5850-5862
Hauptverfasser:	Lopez, Christopher R, Singh, Shivani, Hambarde, Shashank, Griffin, Wezley C, Gao, Jun, Chib, Shubeena, Yu, Yang, Ira, Grzegorz, Raney, Kevin D, Kim, Nayun
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites DNA Helicases - genetics DNA Helicases - metabolism DNA Topoisomerases, Type I - deficiency DNA Topoisomerases, Type I - genetics DNA, Fungal - chemistry DNA, Fungal - genetics DNA, Fungal - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism G-Quadruplexes Gene Expression Regulation, Fungal Genome Genome Integrity, Repair and Genomic Instability Humans Protein Binding Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Sequence Alignment Sequence Homology, Amino Acid Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic
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