Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project
Objective Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2017-06, Vol.69 (6), p.1204-1212 |
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| container_title | Arthritis & rheumatology (Hoboken, N.J.) |
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| creator | Qin, Jin Barbour, Kamil E. Murphy, Louise B. Nelson, Amanda E. Schwartz, Todd A. Helmick, Charles G. Allen, Kelli D. Renner, Jordan B. Baker, Nancy A. Jordan, Joanne M. |
| description | Objective
Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors.
Methods
Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population‐based prospective cohort study among residents of Johnston County, North Carolina. Data for the present study were collected from 2 of the follow‐up cycles (1999–2004 and 2005–2010). Symptomatic hand OA was defined as the presence of both self‐reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop symptomatic hand OA in at least 1 hand by age 85 years, was estimated from models using generalized estimating equations.
Results
Overall, the lifetime risk of symptomatic hand OA was 39.8% (95% confidence interval [95% CI] 34.4–45.3%). In this population, nearly 1 in 2 women (47.2%, 95% CI 40.6–53.9%) had an estimated lifetime risk of developing symptomatic hand OA by age 85 years, compared with 1 in 4 men (24.6%, 95% CI 19.5–30.5%). Race‐specific symptomatic hand OA risk estimates were 41.4% (95% CI 35.5–47.6%) among whites and 29.2% (95% CI 20.5–39.7%) among African Americans. The lifetime risk of symptomatic hand OA among individuals with obesity (47.1%, 95% CI 37.8–56.7%) was 11 percentage points higher than that in individuals without obesity (36.1%, 95% CI 29.7–42.9%).
Conclusion
These findings demonstrate the substantial burden of symptomatic hand OA overall and in sociodemographic and clinical subgroups. Increased use of public health and clinical interventions is needed to address its impact. |
| doi_str_mv | 10.1002/art.40097 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5449255</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1903353228</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4437-7b9684bfdcf586dd6158ad9ae1861b09c4c283965e4d636ef43f9e5462527aef3</originalsourceid><addsrcrecordid>eNp1kV1rFDEUhoMotqy98A9IwBu92DbfM_FCKItaZaFS1zshZDMnbtaZyTbJKPvvTd22aMGrBPLwnPfkReg5JaeUEHZmUzkVhOjmETpmnKm5ZEQ-vrtTTY_QSc5bQm4Yooh8io5YKxqiRXOMvi2DhxIGwFch_8DR4y_7YVfiYEtw-MKOHb7MBWKdskmhhPwGrzaAP8XNmEsc8SJOY9k_YPDnFLfgyjP0xNs-w8ntOUNf379bLS7my8sPHxfny7kTgjfzZq1VK9a-c162qusUla3ttAXaKrom2gnHWq6VBNEprsAL7jVIoZhkjQXPZ-jtwbub1gN0DsaSbG92KQw27U20wfz7MoaN-R5_GimEZlJWwatbQYrXE-RihpAd9L0dIU7Z0FbXUS2hoqIvH6DbOKWxrmeoJpxLzmrYGXp9oFyKOSfw92EoMTe1mfpZ5k9tlX3xd_p78q6kCpwdgF-hh_3_Teb8anVQ_gbzIKKf</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1903353228</pqid></control><display><type>article</type><title>Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Qin, Jin ; Barbour, Kamil E. ; Murphy, Louise B. ; Nelson, Amanda E. ; Schwartz, Todd A. ; Helmick, Charles G. ; Allen, Kelli D. ; Renner, Jordan B. ; Baker, Nancy A. ; Jordan, Joanne M.</creator><creatorcontrib>Qin, Jin ; Barbour, Kamil E. ; Murphy, Louise B. ; Nelson, Amanda E. ; Schwartz, Todd A. ; Helmick, Charles G. ; Allen, Kelli D. ; Renner, Jordan B. ; Baker, Nancy A. ; Jordan, Joanne M.</creatorcontrib><description>Objective
Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors.
Methods
Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population‐based prospective cohort study among residents of Johnston County, North Carolina. Data for the present study were collected from 2 of the follow‐up cycles (1999–2004 and 2005–2010). Symptomatic hand OA was defined as the presence of both self‐reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop symptomatic hand OA in at least 1 hand by age 85 years, was estimated from models using generalized estimating equations.
Results
Overall, the lifetime risk of symptomatic hand OA was 39.8% (95% confidence interval [95% CI] 34.4–45.3%). In this population, nearly 1 in 2 women (47.2%, 95% CI 40.6–53.9%) had an estimated lifetime risk of developing symptomatic hand OA by age 85 years, compared with 1 in 4 men (24.6%, 95% CI 19.5–30.5%). Race‐specific symptomatic hand OA risk estimates were 41.4% (95% CI 35.5–47.6%) among whites and 29.2% (95% CI 20.5–39.7%) among African Americans. The lifetime risk of symptomatic hand OA among individuals with obesity (47.1%, 95% CI 37.8–56.7%) was 11 percentage points higher than that in individuals without obesity (36.1%, 95% CI 29.7–42.9%).
Conclusion
These findings demonstrate the substantial burden of symptomatic hand OA overall and in sociodemographic and clinical subgroups. Increased use of public health and clinical interventions is needed to address its impact.</description><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.40097</identifier><identifier>PMID: 28470947</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Activities of daily living ; African Americans - statistics & numerical data ; Age ; Aged ; Aged, 80 and over ; Arthritis ; Biocompatibility ; Confidence Intervals ; European Continental Ancestry Group - statistics & numerical data ; Female ; Hand ; Health risk assessment ; Hip ; Humans ; Knee ; Male ; Mathematical models ; Men ; Middle Aged ; Models, Statistical ; North Carolina ; Obesity ; Obesity - complications ; Osteoarthritis ; Osteoarthritis - diagnostic imaging ; Osteoarthritis - etiology ; Population studies ; Public health ; Radiography ; Risk analysis ; Risk Factors ; Sex Factors ; Subgroups</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2017-06, Vol.69 (6), p.1204-1212</ispartof><rights>2017, American College of Rheumatology</rights><rights>2017, American College of Rheumatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4437-7b9684bfdcf586dd6158ad9ae1861b09c4c283965e4d636ef43f9e5462527aef3</citedby><cites>FETCH-LOGICAL-c4437-7b9684bfdcf586dd6158ad9ae1861b09c4c283965e4d636ef43f9e5462527aef3</cites><orcidid>0000-0003-3919-0721</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.40097$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.40097$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28470947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qin, Jin</creatorcontrib><creatorcontrib>Barbour, Kamil E.</creatorcontrib><creatorcontrib>Murphy, Louise B.</creatorcontrib><creatorcontrib>Nelson, Amanda E.</creatorcontrib><creatorcontrib>Schwartz, Todd A.</creatorcontrib><creatorcontrib>Helmick, Charles G.</creatorcontrib><creatorcontrib>Allen, Kelli D.</creatorcontrib><creatorcontrib>Renner, Jordan B.</creatorcontrib><creatorcontrib>Baker, Nancy A.</creatorcontrib><creatorcontrib>Jordan, Joanne M.</creatorcontrib><title>Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis Rheumatol</addtitle><description>Objective
Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors.
Methods
Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population‐based prospective cohort study among residents of Johnston County, North Carolina. Data for the present study were collected from 2 of the follow‐up cycles (1999–2004 and 2005–2010). Symptomatic hand OA was defined as the presence of both self‐reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop symptomatic hand OA in at least 1 hand by age 85 years, was estimated from models using generalized estimating equations.
Results
Overall, the lifetime risk of symptomatic hand OA was 39.8% (95% confidence interval [95% CI] 34.4–45.3%). In this population, nearly 1 in 2 women (47.2%, 95% CI 40.6–53.9%) had an estimated lifetime risk of developing symptomatic hand OA by age 85 years, compared with 1 in 4 men (24.6%, 95% CI 19.5–30.5%). Race‐specific symptomatic hand OA risk estimates were 41.4% (95% CI 35.5–47.6%) among whites and 29.2% (95% CI 20.5–39.7%) among African Americans. The lifetime risk of symptomatic hand OA among individuals with obesity (47.1%, 95% CI 37.8–56.7%) was 11 percentage points higher than that in individuals without obesity (36.1%, 95% CI 29.7–42.9%).
Conclusion
These findings demonstrate the substantial burden of symptomatic hand OA overall and in sociodemographic and clinical subgroups. Increased use of public health and clinical interventions is needed to address its impact.</description><subject>Activities of daily living</subject><subject>African Americans - statistics & numerical data</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arthritis</subject><subject>Biocompatibility</subject><subject>Confidence Intervals</subject><subject>European Continental Ancestry Group - statistics & numerical data</subject><subject>Female</subject><subject>Hand</subject><subject>Health risk assessment</subject><subject>Hip</subject><subject>Humans</subject><subject>Knee</subject><subject>Male</subject><subject>Mathematical models</subject><subject>Men</subject><subject>Middle Aged</subject><subject>Models, Statistical</subject><subject>North Carolina</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - diagnostic imaging</subject><subject>Osteoarthritis - etiology</subject><subject>Population studies</subject><subject>Public health</subject><subject>Radiography</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Subgroups</subject><issn>2326-5191</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1rFDEUhoMotqy98A9IwBu92DbfM_FCKItaZaFS1zshZDMnbtaZyTbJKPvvTd22aMGrBPLwnPfkReg5JaeUEHZmUzkVhOjmETpmnKm5ZEQ-vrtTTY_QSc5bQm4Yooh8io5YKxqiRXOMvi2DhxIGwFch_8DR4y_7YVfiYEtw-MKOHb7MBWKdskmhhPwGrzaAP8XNmEsc8SJOY9k_YPDnFLfgyjP0xNs-w8ntOUNf379bLS7my8sPHxfny7kTgjfzZq1VK9a-c162qusUla3ttAXaKrom2gnHWq6VBNEprsAL7jVIoZhkjQXPZ-jtwbub1gN0DsaSbG92KQw27U20wfz7MoaN-R5_GimEZlJWwatbQYrXE-RihpAd9L0dIU7Z0FbXUS2hoqIvH6DbOKWxrmeoJpxLzmrYGXp9oFyKOSfw92EoMTe1mfpZ5k9tlX3xd_p78q6kCpwdgF-hh_3_Teb8anVQ_gbzIKKf</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Qin, Jin</creator><creator>Barbour, Kamil E.</creator><creator>Murphy, Louise B.</creator><creator>Nelson, Amanda E.</creator><creator>Schwartz, Todd A.</creator><creator>Helmick, Charles G.</creator><creator>Allen, Kelli D.</creator><creator>Renner, Jordan B.</creator><creator>Baker, Nancy A.</creator><creator>Jordan, Joanne M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3919-0721</orcidid></search><sort><creationdate>201706</creationdate><title>Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project</title><author>Qin, Jin ; Barbour, Kamil E. ; Murphy, Louise B. ; Nelson, Amanda E. ; Schwartz, Todd A. ; Helmick, Charles G. ; Allen, Kelli D. ; Renner, Jordan B. ; Baker, Nancy A. ; Jordan, Joanne M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4437-7b9684bfdcf586dd6158ad9ae1861b09c4c283965e4d636ef43f9e5462527aef3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Activities of daily living</topic><topic>African Americans - statistics & numerical data</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arthritis</topic><topic>Biocompatibility</topic><topic>Confidence Intervals</topic><topic>European Continental Ancestry Group - statistics & numerical data</topic><topic>Female</topic><topic>Hand</topic><topic>Health risk assessment</topic><topic>Hip</topic><topic>Humans</topic><topic>Knee</topic><topic>Male</topic><topic>Mathematical models</topic><topic>Men</topic><topic>Middle Aged</topic><topic>Models, Statistical</topic><topic>North Carolina</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - diagnostic imaging</topic><topic>Osteoarthritis - etiology</topic><topic>Population studies</topic><topic>Public health</topic><topic>Radiography</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Subgroups</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qin, Jin</creatorcontrib><creatorcontrib>Barbour, Kamil E.</creatorcontrib><creatorcontrib>Murphy, Louise B.</creatorcontrib><creatorcontrib>Nelson, Amanda E.</creatorcontrib><creatorcontrib>Schwartz, Todd A.</creatorcontrib><creatorcontrib>Helmick, Charles G.</creatorcontrib><creatorcontrib>Allen, Kelli D.</creatorcontrib><creatorcontrib>Renner, Jordan B.</creatorcontrib><creatorcontrib>Baker, Nancy A.</creatorcontrib><creatorcontrib>Jordan, Joanne M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qin, Jin</au><au>Barbour, Kamil E.</au><au>Murphy, Louise B.</au><au>Nelson, Amanda E.</au><au>Schwartz, Todd A.</au><au>Helmick, Charles G.</au><au>Allen, Kelli D.</au><au>Renner, Jordan B.</au><au>Baker, Nancy A.</au><au>Jordan, Joanne M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis Rheumatol</addtitle><date>2017-06</date><risdate>2017</risdate><volume>69</volume><issue>6</issue><spage>1204</spage><epage>1212</epage><pages>1204-1212</pages><issn>2326-5191</issn><eissn>2326-5205</eissn><abstract>Objective
Symptomatic hand osteoarthritis (OA) is a common condition that affects hand strength and function, and causes disability in activities of daily living. Prior studies have estimated that the lifetime risk of symptomatic knee OA is 45% and that of hip OA is 25%. The objective of the present study was to estimate the overall lifetime risk of symptomatic hand OA, and the stratified lifetime risk according to potential risk factors.
Methods
Data were obtained from 2,218 adult subjects (ages ≥45 years) in the Johnston County Osteoarthritis Project, a population‐based prospective cohort study among residents of Johnston County, North Carolina. Data for the present study were collected from 2 of the follow‐up cycles (1999–2004 and 2005–2010). Symptomatic hand OA was defined as the presence of both self‐reported symptoms and radiographic OA in the same hand. Lifetime risk, defined as the proportion of the population who will develop symptomatic hand OA in at least 1 hand by age 85 years, was estimated from models using generalized estimating equations.
Results
Overall, the lifetime risk of symptomatic hand OA was 39.8% (95% confidence interval [95% CI] 34.4–45.3%). In this population, nearly 1 in 2 women (47.2%, 95% CI 40.6–53.9%) had an estimated lifetime risk of developing symptomatic hand OA by age 85 years, compared with 1 in 4 men (24.6%, 95% CI 19.5–30.5%). Race‐specific symptomatic hand OA risk estimates were 41.4% (95% CI 35.5–47.6%) among whites and 29.2% (95% CI 20.5–39.7%) among African Americans. The lifetime risk of symptomatic hand OA among individuals with obesity (47.1%, 95% CI 37.8–56.7%) was 11 percentage points higher than that in individuals without obesity (36.1%, 95% CI 29.7–42.9%).
Conclusion
These findings demonstrate the substantial burden of symptomatic hand OA overall and in sociodemographic and clinical subgroups. Increased use of public health and clinical interventions is needed to address its impact.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28470947</pmid><doi>10.1002/art.40097</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3919-0721</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Activities of daily living African Americans - statistics & numerical data Age Aged Aged, 80 and over Arthritis Biocompatibility Confidence Intervals European Continental Ancestry Group - statistics & numerical data Female Hand Health risk assessment Hip Humans Knee Male Mathematical models Men Middle Aged Models, Statistical North Carolina Obesity Obesity - complications Osteoarthritis Osteoarthritis - diagnostic imaging Osteoarthritis - etiology Population studies Public health Radiography Risk analysis Risk Factors Sex Factors Subgroups |
| title | Lifetime Risk of Symptomatic Hand Osteoarthritis: The Johnston County Osteoarthritis Project |
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