Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine
Glycolytic markers have been detected in colorectal cancer (CRC) using advanced analytical methods. Using commercially available assays, by-products of anaerobic metabolism were prospectively measured in the blood and urine of 20 patients with metastatic colorectal cancer (mCRC) and 20 patients with...
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| Veröffentlicht in: | Hypoxia 2017-01, Vol.5, p.61-66 |
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| creator | Jerzak, Katarzyna J Laureano, Marissa Elsharawi, Radwa Kavsak, Peter Chan, Kelvin Kw Dhesy-Thind, Sukhbinder K Zbuk, Kevin |
| description | Glycolytic markers have been detected in colorectal cancer (CRC) using advanced analytical methods.
Using commercially available assays, by-products of anaerobic metabolism were prospectively measured in the blood and urine of 20 patients with metastatic colorectal cancer (mCRC) and 20 patients with local disease. Twenty-four-hour urine citrate, plasma lactate, ketones, venous blood gas, anion gap, and osmolar gap were investigated. Results of patients with metastatic and local CRC were compared using two-sample
-tests or equivalent nonparametric tests. In addition, plasma total CO
concentrations in our local hospital (5,931 inpatients and 1,783 outpatients) were compared retrospectively with those in our dedicated cancer center (1,825 outpatients) over 1 year.
The average venous pCO
was higher in patients with mCRC (50.2 mmHg; standard deviation [SD]=9.36) compared with those with local disease (42.8 mmHg; SD=8.98),
=0.045. Calculated serum osmolarity was higher in mCRC and attributed to concomitant sodium and urea elevations. In our retrospective analysis, plasma total CO
concentrations (median=27 mmol/L) were higher in cancer patients compared to both hospital inpatients (median=23 mmol/L) and outpatients (median=24 mmol/L), |
| doi_str_mv | 10.2147/HP.S127560 |
| format | Article |
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Using commercially available assays, by-products of anaerobic metabolism were prospectively measured in the blood and urine of 20 patients with metastatic colorectal cancer (mCRC) and 20 patients with local disease. Twenty-four-hour urine citrate, plasma lactate, ketones, venous blood gas, anion gap, and osmolar gap were investigated. Results of patients with metastatic and local CRC were compared using two-sample
-tests or equivalent nonparametric tests. In addition, plasma total CO
concentrations in our local hospital (5,931 inpatients and 1,783 outpatients) were compared retrospectively with those in our dedicated cancer center (1,825 outpatients) over 1 year.
The average venous pCO
was higher in patients with mCRC (50.2 mmHg; standard deviation [SD]=9.36) compared with those with local disease (42.8 mmHg; SD=8.98),
=0.045. Calculated serum osmolarity was higher in mCRC and attributed to concomitant sodium and urea elevations. In our retrospective analysis, plasma total CO
concentrations (median=27 mmol/L) were higher in cancer patients compared to both hospital inpatients (median=23 mmol/L) and outpatients (median=24 mmol/L),
<0.0001.
Patients with mCRC had higher venous pCO
levels than those with local disease. Although causation cannot be established, we hypothesize that pCO
elevation may stem from a perturbed metabolism in mCRC.</description><identifier>ISSN: 2324-1128</identifier><identifier>EISSN: 2324-1128</identifier><identifier>DOI: 10.2147/HP.S127560</identifier><identifier>PMID: 28580363</identifier><language>eng</language><publisher>New Zealand: Taylor & Francis Ltd</publisher><subject>Amino acids ; Biomarkers ; Blood tests ; Cancer therapies ; Chromatography ; Clinical medicine ; Colorectal cancer ; Health care ; Hypoxia ; Laboratories ; Mass spectrometry ; Metabolism ; Metabolites ; Metastasis ; Original Research ; Scientific imaging ; Studies ; Systematic review ; Urine ; VOCs ; Volatile organic compounds</subject><ispartof>Hypoxia, 2017-01, Vol.5, p.61-66</ispartof><rights>2017. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017 Jerzak et al. This work is published and licensed by Dove Medical Press Limited 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-d83941c9a83a8bc97b084c422b1680f329cd9428eea2f7028781b6427a9952d73</citedby><orcidid>0000-0002-8580-8580</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449104/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449104/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,3849,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28580363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jerzak, Katarzyna J</creatorcontrib><creatorcontrib>Laureano, Marissa</creatorcontrib><creatorcontrib>Elsharawi, Radwa</creatorcontrib><creatorcontrib>Kavsak, Peter</creatorcontrib><creatorcontrib>Chan, Kelvin Kw</creatorcontrib><creatorcontrib>Dhesy-Thind, Sukhbinder K</creatorcontrib><creatorcontrib>Zbuk, Kevin</creatorcontrib><title>Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine</title><title>Hypoxia</title><addtitle>Hypoxia (Auckl)</addtitle><description>Glycolytic markers have been detected in colorectal cancer (CRC) using advanced analytical methods.
Using commercially available assays, by-products of anaerobic metabolism were prospectively measured in the blood and urine of 20 patients with metastatic colorectal cancer (mCRC) and 20 patients with local disease. Twenty-four-hour urine citrate, plasma lactate, ketones, venous blood gas, anion gap, and osmolar gap were investigated. Results of patients with metastatic and local CRC were compared using two-sample
-tests or equivalent nonparametric tests. In addition, plasma total CO
concentrations in our local hospital (5,931 inpatients and 1,783 outpatients) were compared retrospectively with those in our dedicated cancer center (1,825 outpatients) over 1 year.
The average venous pCO
was higher in patients with mCRC (50.2 mmHg; standard deviation [SD]=9.36) compared with those with local disease (42.8 mmHg; SD=8.98),
=0.045. Calculated serum osmolarity was higher in mCRC and attributed to concomitant sodium and urea elevations. In our retrospective analysis, plasma total CO
concentrations (median=27 mmol/L) were higher in cancer patients compared to both hospital inpatients (median=23 mmol/L) and outpatients (median=24 mmol/L),
<0.0001.
Patients with mCRC had higher venous pCO
levels than those with local disease. Although causation cannot be established, we hypothesize that pCO
elevation may stem from a perturbed metabolism in mCRC.</description><subject>Amino acids</subject><subject>Biomarkers</subject><subject>Blood tests</subject><subject>Cancer therapies</subject><subject>Chromatography</subject><subject>Clinical medicine</subject><subject>Colorectal cancer</subject><subject>Health care</subject><subject>Hypoxia</subject><subject>Laboratories</subject><subject>Mass spectrometry</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metastasis</subject><subject>Original Research</subject><subject>Scientific imaging</subject><subject>Studies</subject><subject>Systematic review</subject><subject>Urine</subject><subject>VOCs</subject><subject>Volatile organic compounds</subject><issn>2324-1128</issn><issn>2324-1128</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkdFqFTEQhoNYbGl74wNIwBsRTk0m2U3ihVCKeoRCC63XYTabPSdlNzkmu0L15U3psVSvZmA-PubnJ-Q1Z2fApfqwvj674aCalr0gRyBArjgH_fLZfkhOS7ljjHEmJAP1ihyCbjQTrTgiv28xb_zsezr5Gbs0pim4QkOkru7ZuxlH6jA6nz9SpGXOOPtNcBR3u5zQbelSQtzUA8Yecx9-VdVYRZVL-Z7OvsyFpoHOW0-7MaWeVpAuOUR_Qg4GHIs_3c9j8v3L59uL9ery6uu3i_PLlROinVe9FkZyZ1AL1J0zqmNaOgnQ8VazQYBxvZGgvUcYFAOtNO9aCQqNaaBX4ph8evTulm7yvfOxphjtLocJ871NGOy_lxi2dpN-2kZKw5msgnd7QU4_lprITqE4P44YfVqK5Ya1XCjTsIq-_Q-9S0uONZ4FACOlNuZB-P6RcjmVkv3w9Axn9qFWu762-1or_Ob5-0_o3xLFH6TMnnc</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Jerzak, Katarzyna J</creator><creator>Laureano, Marissa</creator><creator>Elsharawi, Radwa</creator><creator>Kavsak, Peter</creator><creator>Chan, Kelvin Kw</creator><creator>Dhesy-Thind, Sukhbinder K</creator><creator>Zbuk, Kevin</creator><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8580-8580</orcidid></search><sort><creationdate>20170101</creationdate><title>Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine</title><author>Jerzak, Katarzyna J ; 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Using commercially available assays, by-products of anaerobic metabolism were prospectively measured in the blood and urine of 20 patients with metastatic colorectal cancer (mCRC) and 20 patients with local disease. Twenty-four-hour urine citrate, plasma lactate, ketones, venous blood gas, anion gap, and osmolar gap were investigated. Results of patients with metastatic and local CRC were compared using two-sample
-tests or equivalent nonparametric tests. In addition, plasma total CO
concentrations in our local hospital (5,931 inpatients and 1,783 outpatients) were compared retrospectively with those in our dedicated cancer center (1,825 outpatients) over 1 year.
The average venous pCO
was higher in patients with mCRC (50.2 mmHg; standard deviation [SD]=9.36) compared with those with local disease (42.8 mmHg; SD=8.98),
=0.045. Calculated serum osmolarity was higher in mCRC and attributed to concomitant sodium and urea elevations. In our retrospective analysis, plasma total CO
concentrations (median=27 mmol/L) were higher in cancer patients compared to both hospital inpatients (median=23 mmol/L) and outpatients (median=24 mmol/L),
<0.0001.
Patients with mCRC had higher venous pCO
levels than those with local disease. Although causation cannot be established, we hypothesize that pCO
elevation may stem from a perturbed metabolism in mCRC.</abstract><cop>New Zealand</cop><pub>Taylor & Francis Ltd</pub><pmid>28580363</pmid><doi>10.2147/HP.S127560</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-8580-8580</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Dove Press Free; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Amino acids Biomarkers Blood tests Cancer therapies Chromatography Clinical medicine Colorectal cancer Health care Hypoxia Laboratories Mass spectrometry Metabolism Metabolites Metastasis Original Research Scientific imaging Studies Systematic review Urine VOCs Volatile organic compounds |
| title | Targeted metabolomics in colorectal cancer: a strategic approach using standardized laboratory tests of the blood and urine |
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