Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases

Product template (PT) domains from fungal nonreducing polyketide synthases (NR-PKSs) are responsible for controlling the aldol cyclizations of poly-β-ketone intermediates assembled during the catalytic cycle. Our ability to understand the high regioselective control that PT domains exert is hindered...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-05, Vol.114 (21), p.E4142-E4148
Hauptverfasser:	Barajas, Jesus F., Shakya, Gaurav, Moreno, Gabriel, Rivera, Heriberto, Jackson, David R., Topper, Caitlyn L., Vagstad, Anna L., La Clair, James J., Townsend, Craig A., Burkart, Michael D., Tsai, Shiou-Chuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aldehydes Anchors Biological Sciences Biomimetics Biosynthesis Carbonyl compounds Carbonyls Catalysis Crystal structure Crystallography Docking Fungi In vitro methods and tests Intermediates Ketones Mutagenesis, Site-Directed Pantetheine - isolation & purification Phosphate PNAS Plus Polyketide Synthases - chemistry Polyketide Synthases - genetics Polyketide Synthases - metabolism Polyketides - chemistry Polyketides - metabolism Protein Conformation Proteins Proximity Simulation Thioethers
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