Injectable nanofibrous spongy microspheres for NR4A1 plasmid DNA transfection to reverse fibrotic degeneration and support disc regeneration

Abstract Safe and efficient gene therapy is highly desired for controlling pathogenic fibrosis of nucleus pulposus (NP) tissue, which would result in intervertebral disc (IVD) degeneration and disability if left untreated. In this work, a hyperbranched polymer (HP) with high plasmid DNA (pDNA) bindi...

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Veröffentlicht in:	Biomaterials 2017-07, Vol.131, p.86-97
Hauptverfasser:	Feng, Ganjun, Zhang, Zhanpeng, Dang, Ming, Zhang, Xiaojin, Doleyres, Yasmine, Song, Yueming, Chen, Di, Ma, Peter X., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Aged Animals binding capacity biodegradability Cells, Cultured cytotoxicity Dentistry DNA - administration & dosage DNA - genetics Fibrosis Gene therapy Genetic Therapy - methods Humans Hyperbranched polymer Injections Intervertebral Disc - pathology Intervertebral Disc - physiology Intervertebral Disc Degeneration - genetics Intervertebral Disc Degeneration - pathology Intervertebral Disc Degeneration - therapy intervertebral disks nanofibers Nanofibers - administration & dosage Nanofibers - chemistry nanospheres Nonviral gene carrier Nuclear receptor Nuclear Receptor Subfamily 4, Group A, Member 1 - genetics Nucleus pulposus regeneration plasmids Plasmids - administration & dosage Plasmids - genetics polymers rats Rats, Sprague-Dawley Regeneration tail transfection Transfection - methods
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